STRINGSTRING
HEY2 HEY2 LEPR LEPR SAV1 SAV1 S1PR1 S1PR1 IL7 IL7 ARID2 ARID2 ENSNLEP00000043688 ENSNLEP00000043688 ADRA1A ADRA1A LOC100604571 LOC100604571 MMP13 MMP13 CER1 CER1 ENSNLEP00000045877 ENSNLEP00000045877 TENM4 TENM4 UBE3A UBE3A EHMT2 EHMT2 TSKU TSKU RARG RARG ANKRD26 ANKRD26 ENSNLEP00000048874 ENSNLEP00000048874 RSPO2 RSPO2 ENSNLEP00000049177 ENSNLEP00000049177 ENSNLEP00000027584 ENSNLEP00000027584 SOX9 SOX9 STK3 STK3 MAP2K4 MAP2K4 MAPK11 MAPK11 THBS3 THBS3 COL27A1 COL27A1 PSAP PSAP EVC EVC STC1 STC1 ESR1 ESR1 GATA4 GATA4 FGF8 FGF8 CCDC144A CCDC144A DDR2 DDR2 NPPC NPPC TGFB2 TGFB2 ENSNLEP00000037793 ENSNLEP00000037793 HLX HLX FGF9 FGF9 LEP LEP PTEN PTEN ZMPSTE24 ZMPSTE24 MESP1 MESP1 WNT2 WNT2 IER3IP1 IER3IP1 FGFR3 FGFR3 SORBS2 SORBS2 AKAP13 AKAP13 TGFBR3 TGFBR3 PDGFRB PDGFRB BMP10 BMP10 ECM1 ECM1 NOTCH1 NOTCH1 GATA6 GATA6 OSTN OSTN CYP19A1 CYP19A1 FGF7 FGF7 COMP COMP SMAD1 SMAD1 ACVR2B ACVR2B SMPD3 SMPD3 DIPK2A DIPK2A EXT1 EXT1 TGFBR2 TGFBR2 RARB RARB NDRG4 NDRG4 RARA RARA LOC100598080 LOC100598080 MATN1 MATN1 JARID2 JARID2 AR AR NKX2-5 NKX2-5 TBX5 TBX5 PTPN11 PTPN11 FGFR2 FGFR2 TMEM38B TMEM38B BNC2 BNC2 RAG2 RAG2 PSAPL1 PSAPL1 M3Z9R7_NOMLE M3Z9R7_NOMLE SMAD2 SMAD2 HEG1 HEG1 ENSNLEP00000024736 ENSNLEP00000024736 SPRY2 SPRY2 ENSNLEP00000028086 ENSNLEP00000028086 DLL1 DLL1 STK4 STK4 FXN FXN FGF10 FGF10 PDLIM5 PDLIM5 IFT80 IFT80 YAP1 YAP1 ENSNLEP00000032543 ENSNLEP00000032543 ENSNLEP00000033428 ENSNLEP00000033428 ATF2 ATF2 LOC100605369 LOC100605369 PLAG1 PLAG1 BCL2 BCL2 ENSNLEP00000036739 ENSNLEP00000036739 PRLR PRLR ANXA6 ANXA6 GJE1 GJE1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
LEPRLeptin receptor. (1165 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
IL7Interleukin 7. (179 aa)
ARID2AT-rich interaction domain 2. (1782 aa)
ENSNLEP00000043688Uncharacterized protein. (273 aa)
ADRA1AAdrenoceptor alpha 1A. (470 aa)
LOC100604571ANK_REP_REGION domain-containing protein. (213 aa)
MMP13Matrix metallopeptidase 13. (474 aa)
CER1Cerberus 1, DAN family BMP antagonist. (267 aa)
ENSNLEP00000045877Uncharacterized protein. (116 aa)
TENM4Teneurin transmembrane protein 4. (2768 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (881 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1122 aa)
TSKUTsukushi, small leucine rich proteoglycan. (354 aa)
RARGRetinoic acid receptor gamma. (441 aa)
ANKRD26Ankyrin repeat domain 26. (1708 aa)
ENSNLEP00000048874Uncharacterized protein. (178 aa)
RSPO2R-spondin 2. (250 aa)
ENSNLEP00000049177Uncharacterized protein. (137 aa)
ENSNLEP00000027584SH2 domain-containing protein. (188 aa)
SOX9SRY-box transcription factor 9. (510 aa)
STK3Serine/threonine kinase 3. (519 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
MAPK11Mitogen-activated protein kinase. (350 aa)
THBS3Thrombospondin 3. (938 aa)
COL27A1Collagen type XXVII alpha 1 chain. (1787 aa)
PSAPProsaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. (522 aa)
EVCEvC ciliary complex subunit 1. (983 aa)
STC1Stanniocalcin 1. (247 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
GATA4GATA binding protein 4. (443 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
CCDC144AUncharacterized protein. (1340 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
NPPCNatriuretic peptide C. (129 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ENSNLEP00000037793Uncharacterized protein. (122 aa)
HLXH2.0 like homeobox. (441 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (480 aa)
MESP1Uncharacterized protein. (170 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
IER3IP1Uncharacterized protein. (82 aa)
FGFR3Receptor protein-tyrosine kinase. (583 aa)
SORBS2Sorbin and SH3 domain containing 2. (1201 aa)
AKAP13A-kinase anchoring protein 13. (2761 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
ECM1Extracellular matrix protein 1. (568 aa)
NOTCH1Notch receptor 1. (2451 aa)
GATA6Uncharacterized protein. (452 aa)
OSTNOsteocrin. (133 aa)
CYP19A1Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
COMPTSP C-terminal domain-containing protein. (194 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
DIPK2ADivergent protein kinase domain 2A. (430 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (745 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
RARBRetinoic acid receptor beta. (448 aa)
NDRG4NDRG family member 4. (391 aa)
RARARetinoic acid receptor alpha. (458 aa)
LOC100598080ANK_REP_REGION domain-containing protein. (513 aa)
MATN1Matrilin 1. (496 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1225 aa)
ARUncharacterized protein. (392 aa)
NKX2-5NK2 homeobox 5. (317 aa)
TBX5T-box transcription factor 5. (508 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
FGFR2Fibroblast growth factor receptor. (820 aa)
TMEM38BTransmembrane protein 38B. (291 aa)
BNC2Basonuclin 2. (1099 aa)
RAG2Recombination activating 2. (527 aa)
PSAPL1Proactivator polypeptide-like 1; May activate the lysosomal degradation of sphingolipids. (521 aa)
M3Z9R7_NOMLECCDC144C domain-containing protein. (979 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
HEG1Heart development protein with EGF like domains 1. (1194 aa)
ENSNLEP00000024736Uncharacterized protein. (489 aa)
SPRY2Sprouty RTK signaling antagonist 2. (338 aa)
ENSNLEP00000028086Fork-head domain-containing protein. (459 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (737 aa)
STK4Serine/threonine kinase 4. (490 aa)
FXNUncharacterized protein. (196 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PDLIM5PDZ and LIM domain 5. (619 aa)
IFT80Intraflagellar transport 80. (777 aa)
YAP1Uncharacterized protein. (418 aa)
ENSNLEP00000032543Uncharacterized protein. (168 aa)
ENSNLEP00000033428Protein kinase domain-containing protein. (369 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
LOC100605369Uncharacterized protein. (571 aa)
PLAG1PLAG1 zinc finger. (500 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
ENSNLEP00000036739Uncharacterized protein. (120 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (622 aa)
ANXA6Annexin. (673 aa)
GJE1Gap junction protein epsilon 1. (205 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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