STRINGSTRING
FLT3 FLT3 FLT1 FLT1 MAPKAPK2 MAPKAPK2 ANXA1 ANXA1 SPHK1 SPHK1 FLT4 FLT4 PRKD2 PRKD2 DLL4 DLL4 VEGFB VEGFB GAB1 GAB1 PIK3CA PIK3CA FN1 FN1 NOTCH1 NOTCH1 PIK3CD PIK3CD VEGFD VEGFD PDGFRB PDGFRB RAMP2 RAMP2 VCAM1 VCAM1 ERN1 ERN1 PRKD1 PRKD1 EGR3 EGR3 VEGFC VEGFC NR4A1 NR4A1 MAPK14 MAPK14 NRP1 NRP1 MYO1C MYO1C SPRY2 SPRY2 AKT1 AKT1 ENSNLEP00000028086 ENSNLEP00000028086 PGF PGF NUS1 NUS1 ENSNLEP00000034859 ENSNLEP00000034859 RELA RELA MAP2K3 MAP2K3 NRP2 NRP2 XBP1 XBP1 KDR KDR SEMA6A SEMA6A DAB2IP DAB2IP ITGB1BP1 ITGB1BP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (370 aa)
ANXA1Annexin. (346 aa)
SPHK1DAGKc domain-containing protein. (398 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
PRKD2Uncharacterized protein. (716 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (692 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
FN1Fibronectin 1. (2477 aa)
NOTCH1Notch receptor 1. (2451 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1077 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
RAMP2Receptor activity modifying protein 2. (180 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (977 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa)
EGR3Early growth response 3. (387 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (589 aa)
MAPK14Mitogen-activated protein kinase. (321 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (901 aa)
MYO1CMyosin IC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1023 aa)
SPRY2Sprouty RTK signaling antagonist 2. (338 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
ENSNLEP00000028086Fork-head domain-containing protein. (459 aa)
PGFPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (225 aa)
NUS1NUS1 dehydrodolichyl diphosphate synthase subunit. (293 aa)
ENSNLEP00000034859Uncharacterized protein. (246 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (317 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (930 aa)
XBP1BZIP domain-containing protein. (376 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1367 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1047 aa)
DAB2IPDAB2 interacting protein. (1159 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.