STRINGSTRING
CLDN3 CLDN3 PLEKHN1 PLEKHN1 CASR CASR FAM162A FAM162A NOS1 NOS1 BRIP1 BRIP1 G1QI67_NOMLE G1QI67_NOMLE NR4A2 NR4A2 EDN1 EDN1 CYBB CYBB ZFP36L1 ZFP36L1 HK2 HK2 MMP2 MMP2 RGCC RGCC PENK PENK ATP7A ATP7A ANGPTL4 ANGPTL4 NOS2 NOS2 IL1A IL1A ADAM8 ADAM8 NARF NARF FUNDC1 FUNDC1 DPP4 DPP4 HIF3A HIF3A FABP1 FABP1 EGLN3 EGLN3 BACH1 BACH1 NOP53 NOP53 FMN2 FMN2 SLC6A4 SLC6A4 ITPR1 ITPR1 CAV3 CAV3 SLC29A1 SLC29A1 TGFBR2 TGFBR2 SRF SRF VEGFB VEGFB TREM2 TREM2 PLOD2 PLOD2 AQP3 AQP3 G1QZ78_NOMLE G1QZ78_NOMLE MYC MYC EDNRA EDNRA PDK1 PDK1 NDRG1 NDRG1 LIMD1 LIMD1 APAF1 APAF1 SCAP SCAP HSP90B1 HSP90B1 AGER AGER ADIPOQ ADIPOQ GATA6 GATA6 MST1 MST1 BMP7 BMP7 ATM ATM CBL CBL CHRNA7 CHRNA7 HP1BP3 HP1BP3 SLC2A4 SLC2A4 STUB1 STUB1 PDGFA PDGFA CIAO3 CIAO3 NOTCH1 NOTCH1 REST REST TBL2 TBL2 EGR1 EGR1 CCNA2 CCNA2 VEGFD VEGFD ANGPT4 ANGPT4 SLC9A1 SLC9A1 CREBBP CREBBP OPRD1 OPRD1 ARNT ARNT E2F1 E2F1 AHCY AHCY ABAT ABAT PDK3 PDK3 CLCA1 CLCA1 TGFBR3 TGFBR3 FNDC1 FNDC1 PAM PAM TERT TERT LOC100584360 LOC100584360 UCN3 UCN3 CHRNB2 CHRNB2 BNIP2 BNIP2 STOX1 STOX1 SMAD4 SMAD4 VCAM1 VCAM1 EPO EPO PIN1 PIN1 SIRT1 SIRT1 SUV39H2 SUV39H2 PTEN PTEN SLC2A1 SLC2A1 ERO1A ERO1A SFRP1 SFRP1 P2RX3 P2RX3 SLC39A12 SLC39A12 WDR83 WDR83 TSC1 TSC1 PDLIM1 PDLIM1 MPL MPL ADAM17 ADAM17 TGFB1 TGFB1 EGLN2 EGLN2 BMP2 BMP2 TGFB2 TGFB2 PLK3 PLK3 NPPC NPPC KCNK2 KCNK2 CCN2 CCN2 DDR2 DDR2 SIRT2 SIRT2 HIF1AN HIF1AN AJUBA AJUBA ANGPT2 ANGPT2 PICK1 PICK1 CITED2 CITED2 ATF4 ATF4 AIFM1 AIFM1 GNGT1 GNGT1 SIRT4 SIRT4 CBFA2T3 CBFA2T3 PPARA PPARA SCFD1 SCFD1 STC1 STC1 G1S1R3_NOMLE G1S1R3_NOMLE BNIP3L BNIP3L PTK2B PTK2B ALAS2 ALAS2 DDIT4 DDIT4 TGFB3 TGFB3 NGB NGB PLAU PLAU VEGFC VEGFC PRKCE PRKCE RBPJ RBPJ EPAS1 EPAS1 UCP3 UCP3 UCP2 UCP2 SLC2A8 SLC2A8 ADM ADM ENDOG ENDOG PTGS2 PTGS2 G1SB75_NOMLE G1SB75_NOMLE KCNK3 KCNK3 G1SBL6_NOMLE G1SBL6_NOMLE USF1 USF1 MDM4 MDM4 LOXL2 LOXL2 PPARD PPARD FAM167A FAM167A DNMT3A DNMT3A PINK1 PINK1 CDKN1B CDKN1B SLC11A2 SLC11A2 ENG ENG HILPDA HILPDA CHRNA4 CHRNA4 UBQLN1 UBQLN1 TM9SF4 TM9SF4 CD38 CD38 AKT1 AKT1 PLAT PLAT CPEB2 CPEB2 ENSNLEP00000029139 ENSNLEP00000029139 ENSNLEP00000029241 ENSNLEP00000029241 AK4-2 AK4-2 CA9 CA9 KCNMA1 KCNMA1 SLC8A1 SLC8A1 LOC100605818 LOC100605818 RPTOR RPTOR TXN2 TXN2 ENSNLEP00000030635 ENSNLEP00000030635 NKX3-1 NKX3-1 ENSNLEP00000031077 ENSNLEP00000031077 ENSNLEP00000031088 ENSNLEP00000031088 CRYAB CRYAB BNIP3 BNIP3 ADA ADA ADAM15 ADAM15 ENSNLEP00000032148 ENSNLEP00000032148 CAV1 CAV1 PGF PGF LOC100588486 LOC100588486 KCND2 KCND2 ATF2 ATF2 MTOR MTOR ITPR2 ITPR2 WTIP WTIP VHL VHL EP300 EP300 ENSNLEP00000035981 ENSNLEP00000035981 P4HB P4HB MECP2 MECP2 ARNT2 ARNT2 MGARP MGARP EGLN1 EGLN1 SOD3 SOD3 RORA RORA BCL2 BCL2 CPEB1 CPEB1 MLST8 MLST8 PPARG PPARG LOC100591323 LOC100591323 RYR1 RYR1 EEF2K EEF2K CXCR4 CXCR4 CBS CBS IL18 IL18 BIRC2 BIRC2 BAD BAD HMOX2 HMOX2 CXCL12 CXCL12 HYOU1 HYOU1 HSF1 HSF1 ENSNLEP00000039390 ENSNLEP00000039390 ENSNLEP00000039677 ENSNLEP00000039677 HIPK2 HIPK2 NDNF NDNF HSD11B2 HSD11B2 NF1 NF1 TIGAR TIGAR BBC3 BBC3 SMAD3 SMAD3 ADO ADO ITGA2 ITGA2 ADSL ADSL NFE2L2 NFE2L2 ASCL2 ASCL2 SCN2A SCN2A RYR2 RYR2 THBS1 THBS1 TH TH SLC1A1 SLC1A1 HMOX1 HMOX1 ENSNLEP00000045860 ENSNLEP00000045860 LONP1 LONP1 PML PML LMNA LMNA SLC8A3 SLC8A3 MTHFR MTHFR MYOCD MYOCD CPEB4 CPEB4 ALKBH5 ALKBH5 FOS FOS LOC100603153 LOC100603153 ENSNLEP00000048301 ENSNLEP00000048301 SRC SRC CAPN2 CAPN2 HIF1A HIF1A OXTR OXTR AQP1 AQP1 AK4 AK4 LOC100595279 LOC100595279 PTGIS PTGIS
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CLDN3Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
PLEKHN1Pleckstrin homology domain containing N1. (657 aa)
CASRCalcium sensing receptor. (1088 aa)
FAM162AFamily with sequence similarity 162 member A. (154 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1425 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1229 aa)
G1QI67_NOMLEERAP1_C domain-containing protein. (442 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
EDN1Endothelin 1. (211 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
HK2Hexokinase 2. (917 aa)
MMP2Matrix metallopeptidase 2. (647 aa)
RGCCRegulator of cell cycle. (137 aa)
PENKProenkephalin. (267 aa)
ATP7AATPase copper transporting alpha. (1460 aa)
ANGPTL4Angiopoietin like 4. (379 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1153 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (247 aa)
ADAM8Uncharacterized protein. (678 aa)
NARFNuclear prelamin A recognition factor; Belongs to the NARF family. (478 aa)
FUNDC1FUN14 domain containing 1. (155 aa)
DPP4Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (766 aa)
HIF3AHypoxia inducible factor 3 subunit alpha. (669 aa)
FABP1Fatty acid binding protein 1. (127 aa)
EGLN3Egl-9 family hypoxia inducible factor 3. (239 aa)
BACH1BTB domain and CNC homolog 1. (736 aa)
NOP53Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (478 aa)
FMN2Formin 2. (1613 aa)
SLC6A4Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (625 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2755 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
SLC29A1Solute carrier family 29 member 1 (Augustine blood group). (485 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
SRFSerum response factor. (508 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
TREM2Ig-like domain-containing protein. (222 aa)
PLOD2Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2. (758 aa)
AQP3Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (266 aa)
G1QZ78_NOMLEUncharacterized protein. (162 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
PDK1Protein-serine/threonine kinase. (456 aa)
NDRG1N-myc downstream regulated 1. (394 aa)
LIMD1LIM domains containing 1. (676 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
SCAPSREBF chaperone. (1119 aa)
HSP90B1Heat shock protein 90 beta family member 1. (804 aa)
AGERAdvanced glycosylation end-product specific receptor. (404 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
GATA6Uncharacterized protein. (452 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
BMP7Bone morphogenetic protein 7. (430 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3055 aa)
CBLCbl proto-oncogene. (905 aa)
CHRNA7Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (358 aa)
HP1BP3Heterochromatin protein 1 binding protein 3. (549 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (481 aa)
STUB1Uncharacterized protein. (231 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
CIAO3Cytosolic iron-sulfur assembly component 3; Belongs to the NARF family. (475 aa)
NOTCH1Notch receptor 1. (2451 aa)
RESTRE1 silencing transcription factor. (1097 aa)
TBL2Transducin beta like 2. (447 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (431 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
ANGPT4Angiopoietin 4. (480 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (809 aa)
CREBBPCREB binding protein. (2442 aa)
OPRD1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (265 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (789 aa)
E2F1E2F transcription factor 1. (391 aa)
AHCYAdoHcyase_NAD domain-containing protein; Belongs to the adenosylhomocysteinase family. (422 aa)
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (516 aa)
PDK3Protein-serine/threonine kinase. (415 aa)
CLCA1Chloride channel accessory 1. (914 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
FNDC1Fibronectin type III domain containing 1. (1780 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (979 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (983 aa)
LOC100584360Uncharacterized protein. (532 aa)
UCN3Urocortin 3. (161 aa)
CHRNB2Uncharacterized protein. (329 aa)
BNIP2BCL2 interacting protein 2. (435 aa)
STOX1Storkhead box 1. (937 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
SIRT1Sirtuin 1. (734 aa)
SUV39H2Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (410 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (462 aa)
ERO1AEndoplasmic reticulum oxidoreductase 1 alpha. (468 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (381 aa)
SLC39A12Solute carrier family 39 member 12. (691 aa)
WDR83WD repeat domain 83. (320 aa)
TSC1TSC complex subunit 1. (1164 aa)
PDLIM1PDZ and LIM domain 1. (329 aa)
MPLFibronectin type-III domain-containing protein. (544 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
EGLN2Egl-9 family hypoxia inducible factor 2. (407 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PLK3Polo like kinase 3. (641 aa)
NPPCNatriuretic peptide C. (129 aa)
KCNK2Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (426 aa)
CCN2Cellular communication network factor 2. (349 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (386 aa)
HIF1ANHypoxia inducible factor 1 subunit alpha inhibitor. (349 aa)
AJUBAUncharacterized protein. (121 aa)
ANGPT2Angiopoietin 2. (496 aa)
PICK1Protein interacting with PRKCA 1. (415 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
ATF4BZIP domain-containing protein. (351 aa)
AIFM1Apoptosis inducing factor mitochondria associated 1. (613 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
CBFA2T3CBFA2/RUNX1 partner transcriptional co-repressor 3. (653 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
SCFD1Sec1 family domain containing 1; Belongs to the STXBP/unc-18/SEC1 family. (644 aa)
STC1Stanniocalcin 1. (247 aa)
G1S1R3_NOMLEPeptidase_M1 domain-containing protein. (161 aa)
BNIP3LBCL2 interacting protein 3 like. (219 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (871 aa)
ALAS25-aminolevulinate synthase. (524 aa)
DDIT4DNA damage inducible transcript 4. (232 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
NGBNeuroglobin; Belongs to the globin family. (151 aa)
PLAUPlasminogen activator, urokinase. (414 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (527 aa)
EPAS1Endothelial PAS domain protein 1. (869 aa)
UCP3Uncoupling protein 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (312 aa)
UCP2Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
SLC2A8Solute carrier family 2 member 8; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (477 aa)
ADMAdrenomedullin. (184 aa)
ENDOGEndonuclease. (278 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
G1SB75_NOMLEUncharacterized protein. (81 aa)
KCNK3Ion_trans_2 domain-containing protein. (271 aa)
G1SBL6_NOMLEAdoHcyase_NAD domain-containing protein; Belongs to the adenosylhomocysteinase family. (444 aa)
USF1Upstream transcription factor 1. (310 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa)
LOXL2Lysyl oxidase like 2. (710 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
FAM167AFamily with sequence similarity 167 member A. (214 aa)
DNMT3ADNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (880 aa)
PINK1Protein kinase domain-containing protein. (563 aa)
CDKN1BUncharacterized protein. (204 aa)
SLC11A2Solute carrier family 11 member 2. (568 aa)
ENGEndoglin. (658 aa)
HILPDAHypoxia inducible lipid droplet associated. (63 aa)
CHRNA4Cholinergic receptor nicotinic alpha 4 subunit. (587 aa)
UBQLN1Ubiquilin 1. (589 aa)
TM9SF4Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (642 aa)
CD38CD38 molecule. (300 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (562 aa)
CPEB2Uncharacterized protein. (500 aa)
ENSNLEP00000029139Uncharacterized protein. (145 aa)
ENSNLEP00000029241ADK_lid domain-containing protein; Belongs to the adenylate kinase family. (190 aa)
AK4-2ADK_lid domain-containing protein; Belongs to the adenylate kinase family. (209 aa)
CA9Carbonic anhydrase 9; Belongs to the alpha-carbonic anhydrase family. (447 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1289 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (972 aa)
LOC100605818BZIP domain-containing protein. (347 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1318 aa)
TXN2Thioredoxin domain-containing protein. (186 aa)
ENSNLEP00000030635Uncharacterized protein; Belongs to the complex I LYR family. (70 aa)
NKX3-1NK3 homeobox 1. (230 aa)
ENSNLEP00000031077Neur_chan_LBD domain-containing protein. (158 aa)
ENSNLEP00000031088Protein kinase domain-containing protein. (557 aa)
CRYABCrystallin alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
BNIP3Uncharacterized protein. (231 aa)
ADAAdenosine deaminase. (405 aa)
ADAM15Uncharacterized protein. (670 aa)
ENSNLEP00000032148LRRNT domain-containing protein. (382 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
PGFPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (225 aa)
LOC100588486Uncharacterized protein. (509 aa)
KCND2Potassium voltage-gated channel subfamily D member 2; Belongs to the potassium channel family. (630 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2578 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2727 aa)
WTIPUncharacterized protein. (235 aa)
VHLVon Hippel-Lindau tumor suppressor. (213 aa)
EP300E1A binding protein p300. (2306 aa)
ENSNLEP00000035981Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (393 aa)
P4HBProtein disulfide-isomerase. (518 aa)
MECP2MBD domain-containing protein. (156 aa)
ARNT2Uncharacterized protein. (699 aa)
MGARPMitochondria localized glutamic acid rich protein. (238 aa)
EGLN1Egl-9 family hypoxia inducible factor 1. (416 aa)
SOD3Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (240 aa)
RORARAR related orphan receptor A. (555 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
CPEB1Cytoplasmic polyadenylation element binding protein 1. (615 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
LOC100591323Uncharacterized protein. (917 aa)
RYR1Ryanodine receptor 1. (4415 aa)
EEF2KEukaryotic elongation factor 2 kinase. (725 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (375 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (551 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
BIRC2Baculoviral IAP repeat containing 2. (615 aa)
BADUncharacterized protein. (82 aa)
HMOX2Heme oxygenase 2. (370 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
HYOU1Hypoxia up-regulated 1. (956 aa)
HSF1HSF_DOMAIN domain-containing protein. (272 aa)
ENSNLEP00000039390Protein kinase domain-containing protein. (673 aa)
ENSNLEP00000039677AdoHcyase_NAD domain-containing protein. (412 aa)
HIPK2Homeodomain interacting protein kinase 2. (1198 aa)
NDNFNeuron derived neurotrophic factor. (568 aa)
HSD11B2Hydroxysteroid 11-beta dehydrogenase 2. (445 aa)
NF1Neurofibromin 1. (2839 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
BBC3BCL2 binding component 3. (237 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
ADOUncharacterized protein. (216 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1181 aa)
ADSLAdenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (498 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (607 aa)
ASCL2Achaete-scute family bHLH transcription factor 2. (193 aa)
SCN2ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1939 aa)
RYR2Ryanodine receptor 2. (4825 aa)
THBS1Thrombospondin 1. (1173 aa)
THTyrosine hydroxylase. (507 aa)
SLC1A1Amino acid transporter. (457 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
ENSNLEP00000045860Uncharacterized protein. (64 aa)
LONP1Lon proteolytic domain-containing protein; Belongs to the peptidase S16 family. (722 aa)
PMLUncharacterized protein. (873 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (664 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
MTHFRMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (654 aa)
MYOCDMyocardin. (986 aa)
CPEB4Cytoplasmic polyadenylation element binding protein 4. (718 aa)
ALKBH5AlkB homolog 5, RNA demethylase. (380 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
LOC100603153Uncharacterized protein. (445 aa)
ENSNLEP00000048301Peptidyl-prolyl cis-trans isomerase. (144 aa)
SRCTyrosine-protein kinase. (537 aa)
CAPN2Calpain 2; Belongs to the peptidase C2 family. (660 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
OXTROxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (389 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
AK4Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (223 aa)
LOC100595279Uncharacterized protein. (212 aa)
PTGISProstacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (500 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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