(16 nodes) ERBB2 signaling pathway network (Nomascus leucogenys)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

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Your Input:
	MYOC	Myocilin. (526 aa)
	EGF	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
	PTK6	Tyrosine-protein kinase. (451 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1247 aa)
	AREG	EGF-like domain-containing protein. (274 aa)
	SRC	Tyrosine-protein kinase. (537 aa)
	ERBB3	Erb-b2 receptor tyrosine kinase 3. (1343 aa)
	PTPRR	Protein tyrosine phosphatase receptor type R. (657 aa)
	NRG1	Neuregulin 1. (713 aa)
	EGFR	Receptor protein-tyrosine kinase. (1206 aa)
	ERBB4	Receptor protein-tyrosine kinase. (1308 aa)
	EREG	Epiregulin. (169 aa)
	BTC	Betacellulin. (178 aa)
	STUB1	Uncharacterized protein. (231 aa)
	HBEGF	Heparin binding EGF like growth factor. (208 aa)
	TGFA	Transforming growth factor alpha. (166 aa)

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AREG	BTC	ENSNLEP00000040124	ENSNLEP00000009692	EGF-like domain-containing protein.	Betacellulin.	0.873
AREG	EGF	ENSNLEP00000040124	ENSNLEP00000020085	EGF-like domain-containing protein.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.936
AREG	EGFR	ENSNLEP00000040124	ENSNLEP00000035792	EGF-like domain-containing protein.	Receptor protein-tyrosine kinase.	0.997
AREG	ERBB2	ENSNLEP00000040124	ENSNLEP00000048945	EGF-like domain-containing protein.	Receptor protein-tyrosine kinase.	0.926
AREG	ERBB3	ENSNLEP00000040124	ENSNLEP00000047229	EGF-like domain-containing protein.	Erb-b2 receptor tyrosine kinase 3.	0.952
AREG	ERBB4	ENSNLEP00000040124	ENSNLEP00000008780	EGF-like domain-containing protein.	Receptor protein-tyrosine kinase.	0.951
AREG	EREG	ENSNLEP00000040124	ENSNLEP00000009683	EGF-like domain-containing protein.	Epiregulin.	0.936
AREG	HBEGF	ENSNLEP00000040124	ENSNLEP00000011230	EGF-like domain-containing protein.	Heparin binding EGF like growth factor.	0.673
AREG	SRC	ENSNLEP00000040124	ENSNLEP00000048569	EGF-like domain-containing protein.	Tyrosine-protein kinase.	0.601
AREG	TGFA	ENSNLEP00000040124	ENSNLEP00000012418	EGF-like domain-containing protein.	Transforming growth factor alpha.	0.815
BTC	AREG	ENSNLEP00000009692	ENSNLEP00000040124	Betacellulin.	EGF-like domain-containing protein.	0.873
BTC	EGF	ENSNLEP00000009692	ENSNLEP00000020085	Betacellulin.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.857
BTC	EGFR	ENSNLEP00000009692	ENSNLEP00000035792	Betacellulin.	Receptor protein-tyrosine kinase.	0.995
BTC	ERBB2	ENSNLEP00000009692	ENSNLEP00000048945	Betacellulin.	Receptor protein-tyrosine kinase.	0.758
BTC	ERBB3	ENSNLEP00000009692	ENSNLEP00000047229	Betacellulin.	Erb-b2 receptor tyrosine kinase 3.	0.852
BTC	ERBB4	ENSNLEP00000009692	ENSNLEP00000008780	Betacellulin.	Receptor protein-tyrosine kinase.	0.991
BTC	EREG	ENSNLEP00000009692	ENSNLEP00000009683	Betacellulin.	Epiregulin.	0.644
BTC	HBEGF	ENSNLEP00000009692	ENSNLEP00000011230	Betacellulin.	Heparin binding EGF like growth factor.	0.820
BTC	NRG1	ENSNLEP00000009692	ENSNLEP00000045791	Betacellulin.	Neuregulin 1.	0.560
BTC	SRC	ENSNLEP00000009692	ENSNLEP00000048569	Betacellulin.	Tyrosine-protein kinase.	0.524

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