(49 nodes) Cellular response to glucose starvation network (Nomascus leucogenys)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	EIF2AK3	Eukaryotic translation initiation factor 2 alpha kinase 3. (1120 aa)
	MTMR3	Myotubularin related protein 3. (1083 aa)
	UPP1	Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (310 aa)
	CHKA	Choline kinase alpha. (438 aa)
	IMPACT	Impact RWD domain protein. (320 aa)
	TBL2	Transducin beta like 2. (447 aa)
	PRKAG3	Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
	NIM1K	NIM1 serine/threonine protein kinase; Belongs to the protein kinase superfamily. (436 aa)
	BRSK1	UBA domain-containing protein. (449 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (560 aa)
	BECN1	Beclin 1. (450 aa)
	SIRT1	Sirtuin 1. (734 aa)
	SLC2A1	Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (462 aa)
	SESN1	Sestrin 1. (551 aa)
	ATG14	Autophagy related 14. (492 aa)
	IFI16	Interferon gamma inducible protein 16. (723 aa)
	BRSK2	BR serine/threonine kinase 2. (739 aa)
	PLIN3	Perilipin; Belongs to the perilipin family. (395 aa)
	NUAK2	NUAK family kinase 2. (672 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (552 aa)
	PICK1	Protein interacting with PRKCA 1. (415 aa)
	ATF4	BZIP domain-containing protein. (351 aa)
	C12orf66	Chromosome 12 open reading frame 66. (468 aa)
	MYBBP1A	MYB binding protein 1a. (1271 aa)
	HSPA5	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
	RRP8	Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (447 aa)
	PLIN2	Perilipin; Belongs to the perilipin family. (445 aa)
	BHLHA15	Basic helix-loop-helix family member a15. (189 aa)
	SZT2	SZT2 subunit of KICSTOR complex. (3454 aa)
	SESN2	Sestrin 2. (470 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (895 aa)
	PRKAG2	Protein kinase AMP-activated non-catalytic subunit gamma 2. (569 aa)
	LOC100605818	BZIP domain-containing protein. (347 aa)
	PRKAG1	Protein kinase AMP-activated non-catalytic subunit gamma 1. (333 aa)
	ENSNLEP00000033843	Uncharacterized protein. (63 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (574 aa)
	ENSNLEP00000034469	Uncharacterized protein. (99 aa)
	PIK3R4	Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	KAT5	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (535 aa)
	ENSNLEP00000038312	Uncharacterized protein; Belongs to the heat shock protein 70 family. (615 aa)
	NUAK1	NUAK family kinase 1. (667 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (607 aa)
	XBP1	BZIP domain-containing protein. (376 aa)
	SLC7A5	Solute carrier family 7 member 5. (507 aa)
	CPEB4	Cytoplasmic polyadenylation element binding protein 4. (718 aa)
	SESN3	Sestrin 3. (520 aa)
	SIK1	Uncharacterized protein. (770 aa)
	KPTN	Kaptin, actin binding protein. (429 aa)

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATF4	EIF2AK3	ENSNLEP00000018522	ENSNLEP00000003807	BZIP domain-containing protein.	Eukaryotic translation initiation factor 2 alpha kinase 3.	0.964
ATF4	ENSNLEP00000038312	ENSNLEP00000018522	ENSNLEP00000038312	BZIP domain-containing protein.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.734
ATF4	HSPA5	ENSNLEP00000018522	ENSNLEP00000021061	BZIP domain-containing protein.	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	0.734
ATF4	NFE2L2	ENSNLEP00000018522	ENSNLEP00000042804	BZIP domain-containing protein.	Nuclear factor, erythroid 2 like 2.	0.673
ATF4	XBP1	ENSNLEP00000018522	ENSNLEP00000043246	BZIP domain-containing protein.	BZIP domain-containing protein.	0.646
ATG14	BCL2	ENSNLEP00000015560	ENSNLEP00000036597	Autophagy related 14.	BCL2 apoptosis regulator.	0.770
ATG14	BECN1	ENSNLEP00000015560	ENSNLEP00000014406	Autophagy related 14.	Beclin 1.	0.999
ATG14	PIK3C3	ENSNLEP00000015560	ENSNLEP00000029230	Autophagy related 14.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.999
ATG14	PIK3R4	ENSNLEP00000015560	ENSNLEP00000036371	Autophagy related 14.	Phosphoinositide-3-kinase regulatory subunit 4.	0.999
ATG14	PRKAA1	ENSNLEP00000015560	ENSNLEP00000034028	Autophagy related 14.	Non-specific serine/threonine protein kinase.	0.581
ATG14	PRKAA2	ENSNLEP00000015560	ENSNLEP00000017863	Autophagy related 14.	Non-specific serine/threonine protein kinase.	0.591
ATG14	PRKAG2	ENSNLEP00000015560	ENSNLEP00000030220	Autophagy related 14.	Protein kinase AMP-activated non-catalytic subunit gamma 2.	0.481
BCL2	ATG14	ENSNLEP00000036597	ENSNLEP00000015560	BCL2 apoptosis regulator.	Autophagy related 14.	0.770
BCL2	BECN1	ENSNLEP00000036597	ENSNLEP00000014406	BCL2 apoptosis regulator.	Beclin 1.	0.999
BCL2	EIF2AK3	ENSNLEP00000036597	ENSNLEP00000003807	BCL2 apoptosis regulator.	Eukaryotic translation initiation factor 2 alpha kinase 3.	0.542
BCL2	ENSNLEP00000038312	ENSNLEP00000036597	ENSNLEP00000038312	BCL2 apoptosis regulator.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.467
BCL2	HSPA5	ENSNLEP00000036597	ENSNLEP00000021061	BCL2 apoptosis regulator.	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	0.467
BCL2	NFE2L2	ENSNLEP00000036597	ENSNLEP00000042804	BCL2 apoptosis regulator.	Nuclear factor, erythroid 2 like 2.	0.489
BCL2	PIK3C3	ENSNLEP00000036597	ENSNLEP00000029230	BCL2 apoptosis regulator.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.785
BCL2	PIK3R4	ENSNLEP00000036597	ENSNLEP00000036371	BCL2 apoptosis regulator.	Phosphoinositide-3-kinase regulatory subunit 4.	0.489

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