STRINGSTRING
EGF EGF MAP3K12 MAP3K12 TRAF6 TRAF6 LRRK2 LRRK2 PTPRC PTPRC FZD10 FZD10 G1SB75_NOMLE G1SB75_NOMLE DVL3 DVL3 TNFSF11 TNFSF11 LOC100607679 LOC100607679 ENSNLEP00000027432 ENSNLEP00000027432 EZH2 EZH2 ADAM9 ADAM9 DUSP19 DUSP19 PSEN1 PSEN1 CD40 CD40 LOC100588486 LOC100588486 MEF2C MEF2C TLR6 TLR6 FZD4 FZD4 EGFR EGFR FGF2 FGF2 ENSNLEP00000038711 ENSNLEP00000038711 ROBO1 ROBO1 PAK1 PAK1 ENSNLEP00000039390 ENSNLEP00000039390 HTR2A HTR2A PDGFC PDGFC EDN3 EDN3 TPD52L1 TPD52L1 EPHA4 EPHA4 DVL2 DVL2 THBS1 THBS1 ENSNLEP00000044067 ENSNLEP00000044067 DAB2IP DAB2IP IL1B IL1B ENSNLEP00000045822 ENSNLEP00000045822 LOC100584186 LOC100584186 GHR GHR FZD5 FZD5 TNF TNF EPGN EPGN MAP3K5 MAP3K5 RPS3 RPS3 HTR2B HTR2B SRC SRC ARHGEF5 ARHGEF5 AXIN1 AXIN1 ERBB2 ERBB2 ERP29 ERP29 G1QHL5_NOMLE G1QHL5_NOMLE TAOK3 TAOK3 FLT3 FLT3 INSR INSR SYK SYK ROR2 ROR2 FLT1 FLT1 EDN1 EDN1 NOD2 NOD2 ELANE ELANE MAP2K7 MAP2K7 ADAM8 ADAM8 MAP2K6 MAP2K6 NTF3 NTF3 NEK10 NEK10 PDCD10 PDCD10 MAP4K2 MAP4K2 KITLG KITLG MAP3K11 MAP3K11 TDGF1 TDGF1 MAP3K13 MAP3K13 AGER AGER MST1R MST1R WNT5A WNT5A MAGED1 MAGED1 PDGFA PDGFA HRAS HRAS KIT KIT DRD4 DRD4 TNFRSF11A TNFRSF11A TRAF2 TRAF2 PIK3CG PIK3CG PDE5A PDE5A FGF1 FGF1 PIK3R5 PIK3R5 TGFA TGFA PDGFRB PDGFRB S100A12 S100A12 FGD2 FGD2 AKAP13 AKAP13 NTRK3 NTRK3 MAP3K4 MAP3K4 RASGRP1 RASGRP1 ERN2 ERN2 DKK1 DKK1 FGFR1 FGFR1 MAP2K5 MAP2K5 MAP3K7 MAP3K7 TGFB1 TGFB1 MAP3K10 MAP3K10 CSK CSK AJUBA AJUBA ERN1 ERN1 TENM1 TENM1 PDGFB PDGFB SASH1 SASH1 PLA2G1B PLA2G1B P2RX7 P2RX7 IL34 IL34 PTK2B PTK2B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12. (747 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1304 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
G1SB75_NOMLEUncharacterized protein. (81 aa)
DVL3Dishevelled segment polarity protein 3. (673 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
LOC100607679SCY domain-containing protein. (98 aa)
ENSNLEP00000027432TNF receptor-associated factor. (488 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
ADAM9ADAM metallopeptidase domain 9. (819 aa)
DUSP19Dual specificity phosphatase 19; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (218 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
CD40TNFR-Cys domain-containing protein. (219 aa)
LOC100588486Uncharacterized protein. (509 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
TLR6TIR domain-containing protein. (472 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (287 aa)
ENSNLEP00000038711CFC domain-containing protein. (158 aa)
ROBO1Roundabout guidance receptor 1. (1651 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
ENSNLEP00000039390Protein kinase domain-containing protein. (673 aa)
HTR2A5-hydroxytryptamine receptor 2A. (471 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
EDN3Uncharacterized protein. (211 aa)
TPD52L1TPD52 like 1. (221 aa)
EPHA4EPH receptor A4. (967 aa)
DVL2Dishevelled segment polarity protein 2. (713 aa)
THBS1Thrombospondin 1. (1173 aa)
ENSNLEP00000044067Uncharacterized protein. (108 aa)
DAB2IPDAB2 interacting protein. (1159 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
ENSNLEP00000045822Uncharacterized protein. (244 aa)
LOC100584186KH type-2 domain-containing protein. (260 aa)
GHRGrowth hormone receptor. (645 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
EPGNEpithelial mitogen. (154 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1347 aa)
RPS3Ribosomal_S3_C domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (190 aa)
HTR2BG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (398 aa)
SRCTyrosine-protein kinase. (537 aa)
ARHGEF5DH domain-containing protein. (302 aa)
AXIN1Axin 1. (837 aa)
ERBB2Receptor protein-tyrosine kinase. (1247 aa)
ERP29Endoplasmic reticulum resident protein 29; Does not seem to be a disulfide isomerase. (261 aa)
G1QHL5_NOMLEUncharacterized protein; Belongs to the heparin-binding growth factors family. (182 aa)
TAOK3TAO kinase 3. (898 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
INSRInsulin receptor. (1232 aa)
SYKTyrosine-protein kinase. (532 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (915 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
EDN1Endothelin 1. (211 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (239 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (391 aa)
ADAM8Uncharacterized protein. (678 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (268 aa)
NEK10Protein kinase domain-containing protein. (1173 aa)
PDCD10Programmed cell death 10. (212 aa)
MAP4K2Uncharacterized protein. (658 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase. (847 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (188 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (966 aa)
AGERAdvanced glycosylation end-product specific receptor. (404 aa)
MST1RMacrophage stimulating 1 receptor. (1312 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
MAGED1MAGE family member D1. (823 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (969 aa)
DRD4Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (386 aa)
TNFRSF11ATNF receptor superfamily member 11a. (595 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
PDE5APhosphodiesterase. (875 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (889 aa)
TGFATransforming growth factor alpha. (166 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
S100A12S100 calcium binding protein A12; Belongs to the S-100 family. (91 aa)
FGD2FYVE, RhoGEF and PH domain containing 2. (648 aa)
AKAP13A-kinase anchoring protein 13. (2761 aa)
NTRK3Tyrosine-protein kinase receptor. (706 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1592 aa)
RASGRP1RAS guanyl releasing protein 1. (785 aa)
ERN2Endoplasmic reticulum to nucleus signaling 2. (914 aa)
DKK1Dickkopf-like protein 1. (266 aa)
FGFR1Fibroblast growth factor receptor. (835 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (414 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
MAP3K10Protein kinase domain-containing protein. (689 aa)
CSKTyrosine-protein kinase. (274 aa)
AJUBAUncharacterized protein. (121 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (977 aa)
TENM1Teneurin transmembrane protein 1. (2731 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (233 aa)
SASH1SAM and SH3 domain containing 1. (1247 aa)
PLA2G1BPhospholipase A(2). (148 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
IL34Interleukin 34. (242 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (871 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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