STRINGSTRING
ANGPT4 ANGPT4 ALOX12 ALOX12 RHOJ RHOJ GATA2 GATA2 AMOT AMOT PDGFB PDGFB PRKD1 PRKD1 HDAC9 HDAC9 VEGFC VEGFC JCAD JCAD SRPX2 SRPX2 ETS1 ETS1 PLCG1 PLCG1 MAP3K3 MAP3K3 NOS3 NOS3 PRKD2 PRKD2 PLK2 PLK2 ANXA1 ANXA1 G1QHL5_NOMLE G1QHL5_NOMLE PRKCA PRKCA HIF1A HIF1A HMOX1 HMOX1 KDR KDR THBS1 THBS1 P2RX4 P2RX4 ATP5F1A ATP5F1A NFE2L2 NFE2L2 MAP2K3 MAP2K3 ANGPT1 ANGPT1 LOC100593010 LOC100593010 HDAC7 HDAC7 FGF2 FGF2 ENSNLEP00000034859 ENSNLEP00000034859 NUS1 NUS1 ENSNLEP00000034659 ENSNLEP00000034659 CD40 CD40 AKT1 AKT1 ATP5F1B ATP5F1B NRP1 NRP1 M3ZBW0_NOMLE M3ZBW0_NOMLE AKT3 AKT3 PTGS2 PTGS2 SP1 SP1 TGFB1 TGFB1 ADAM17 ADAM17 ABL1 ABL1 FGFR1 FGFR1 SIRT1 SIRT1 CIB1 CIB1 LOC100592336 LOC100592336
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ANGPT4Angiopoietin 4. (480 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (639 aa)
RHOJRas homolog family member J. (215 aa)
GATA2GATA binding protein 2. (480 aa)
AMOTAngiomotin. (1088 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (233 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1066 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
JCADJunctional cadherin 5 associated. (1354 aa)
SRPX2Sushi repeat containing protein X-linked 2. (425 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1182 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (628 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1128 aa)
PRKD2Uncharacterized protein. (716 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
ANXA1Annexin. (346 aa)
G1QHL5_NOMLEUncharacterized protein; Belongs to the heparin-binding growth factors family. (182 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1367 aa)
THBS1Thrombospondin 1. (1173 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (404 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (545 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (607 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (317 aa)
ANGPT1Angiopoietin 1. (498 aa)
LOC100593010Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (459 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1004 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (287 aa)
ENSNLEP00000034859Uncharacterized protein. (246 aa)
NUS1NUS1 dehydrodolichyl diphosphate synthase subunit. (293 aa)
ENSNLEP00000034659Uncharacterized protein. (407 aa)
CD40TNFR-Cys domain-containing protein. (219 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (509 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (901 aa)
M3ZBW0_NOMLESH2 domain-containing protein. (230 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
SP1Sp1 transcription factor. (786 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
ABL1Tyrosine-protein kinase. (1006 aa)
FGFR1Fibroblast growth factor receptor. (835 aa)
SIRT1Sirtuin 1. (734 aa)
CIB1Uncharacterized protein. (187 aa)
LOC100592336PH_3 domain-containing protein. (247 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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