STRINGSTRING
NOTCH1 NOTCH1 GCN1 GCN1 NFE2L1 NFE2L1 CREB3L3 CREB3L3 ATF3 ATF3 BACH1 BACH1 INO80 INO80 NCK1 NCK1 KLF2 KLF2 ATF6B ATF6B IMPACT IMPACT NEDD4 NEDD4 MAPK7 MAPK7 EGR1 EGR1 MBTPS2 MBTPS2 ARNT ARNT STOX1 STOX1 MUC1 MUC1 G1RT21_NOMLE G1RT21_NOMLE CREB3L1 CREB3L1 ANKRD2 ANKRD2 ATF6 ATF6 SIRT2 SIRT2 JUN JUN HIF1AN HIF1AN CITED2 CITED2 ATF4 ATF4 BAG3 BAG3 RBPJ RBPJ EPAS1 EPAS1 DDIT3 DDIT3 SESN2 SESN2 LOC100605818 LOC100605818 NCK2 NCK2 ENSNLEP00000032236 ENSNLEP00000032236 VHL VHL HSF1 HSF1 CHEK1 CHEK1 NFE2L2 NFE2L2 XBP1 XBP1 SIN3A SIN3A ENSNLEP00000045860 ENSNLEP00000045860 CHD6 CHD6 HIF1A HIF1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NOTCH1Notch receptor 1. (2451 aa)
GCN1GCN1 activator of EIF2AK4. (2636 aa)
NFE2L1Nuclear factor, erythroid 2 like 1. (757 aa)
CREB3L3BZIP domain-containing protein. (406 aa)
ATF3Activating transcription factor 3. (181 aa)
BACH1BTB domain and CNC homolog 1. (736 aa)
INO80INO80 complex ATPase subunit. (1538 aa)
NCK1Cytoplasmic protein. (377 aa)
KLF2Kruppel like factor 2. (355 aa)
ATF6BActivating transcription factor 6 beta. (718 aa)
IMPACTImpact RWD domain protein. (320 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1319 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
MBTPS2Membrane bound transcription factor peptidase, site 2. (502 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (789 aa)
STOX1Storkhead box 1. (937 aa)
MUC1Mucin 1, cell surface associated. (483 aa)
G1RT21_NOMLEJ domain-containing protein. (311 aa)
CREB3L1BZIP domain-containing protein. (467 aa)
ANKRD2Ankyrin repeat domain 2. (360 aa)
ATF6Activating transcription factor 6. (657 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (386 aa)
JUNBZIP domain-containing protein; Belongs to the bZIP family. (305 aa)
HIF1ANHypoxia inducible factor 1 subunit alpha inhibitor. (349 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
ATF4BZIP domain-containing protein. (351 aa)
BAG3BCL2 associated athanogene 3. (574 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (527 aa)
EPAS1Endothelial PAS domain protein 1. (869 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa)
SESN2Sestrin 2. (470 aa)
LOC100605818BZIP domain-containing protein. (347 aa)
NCK2Cytoplasmic protein. (380 aa)
ENSNLEP00000032236Uncharacterized protein. (109 aa)
VHLVon Hippel-Lindau tumor suppressor. (213 aa)
HSF1HSF_DOMAIN domain-containing protein. (272 aa)
CHEK1Checkpoint kinase 1. (492 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (607 aa)
XBP1BZIP domain-containing protein. (376 aa)
SIN3ASIN3 transcription regulator family member A. (1250 aa)
ENSNLEP00000045860Uncharacterized protein. (64 aa)
CHD6Chromodomain helicase DNA binding protein 6. (2696 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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