STRINGSTRING
DDR1 DDR1 LNPEP LNPEP PMP22 PMP22 ANGPT2 ANGPT2 CITED2 CITED2 MAFF MAFF CTSB CTSB ESR1 ESR1 STC1 STC1 NODAL NODAL ACOD1 ACOD1 MAGED2 MAGED2 TGFB3 TGFB3 HSD11B2 HSD11B2 IGFBP7 IGFBP7 ENSNLEP00000039759 ENSNLEP00000039759 LOC100580006 LOC100580006 G1S3Q0_NOMLE G1S3Q0_NOMLE AMBP AMBP PAPPA PAPPA CBS CBS ADRA2B ADRA2B CSMD1 CSMD1 ENSNLEP00000037562 ENSNLEP00000037562 PRLR PRLR PLA2G6 PLA2G6 LDOC1 LDOC1 BCL2 BCL2 ENSNLEP00000035822 ENSNLEP00000035822 LOC100597420 LOC100597420 JUNB JUNB COL16A1 COL16A1 TRO TRO PGF PGF THBD THBD ITGB3 ITGB3 SPHK2 SPHK2 CRH CRH TRIM28 TRIM28 CSMD2 CSMD2 ENSNLEP00000028388 ENSNLEP00000028388 AKT1 AKT1 CD38 CD38 CLIC5 CLIC5 AVPR1A AVPR1A CYP27B1 CYP27B1 P2RX1 P2RX1 CORIN CORIN TAC3 TAC3 ADM ADM ITGA5 ITGA5 VDR VDR ENDOU ENDOU PTGS2 PTGS2 RGS2 RGS2 CLDN4 CLDN4 G1SB02_NOMLE G1SB02_NOMLE PPARD PPARD ENSNLEP00000025665 ENSNLEP00000025665 TACR1 TACR1 PTN PTN TAC1 TAC1 ARG1 ARG1 DEDD DEDD TGFB1 TGFB1 CEACAM5 CEACAM5 PRDM1 PRDM1 KLF1 KLF1 DDO DDO CRHBP CRHBP IDO1 IDO1 EPOR EPOR SLC2A1 SLC2A1 ASH1L ASH1L A1CF A1CF EPO EPO STAT5B STAT5B UBE2Q1 UBE2Q1 PRDM14 PRDM14 PAM PAM STOX2 STOX2 PTGFR PTGFR PTAFR PTAFR SERPINE2 SERPINE2 SPP1 SPP1 GNAS GNAS ACVR2A ACVR2A IHH IHH ITGA3 ITGA3 FUT7 FUT7 STS STS LAMB1 LAMB1 OXT OXT IGFBP5 IGFBP5 IGFBP2 IGFBP2 PGR PGR SLC38A3 SLC38A3 MST1 MST1 MMP9 MMP9 ADCYAP1 ADCYAP1 HPGD HPGD DSG1 DSG1 FOSL1 FOSL1 EPYC EPYC GHSR GHSR MEN1 MEN1 FBLN1 FBLN1 TEAD4 TEAD4 ENSNLEP00000041273 ENSNLEP00000041273 ABCC8 ABCC8 BMPR2 BMPR2 EMP2 EMP2 ITGA2 ITGA2 ENSNLEP00000042687 ENSNLEP00000042687 DAZAP1 DAZAP1 PRLHR PRLHR IL1B IL1B TEAD3 TEAD3 NR2F2 NR2F2 SP3 SP3 FOS FOS EDDM3B EDDM3B LOC100606651 LOC100606651 RAM2 RAM2 CAPN2 CAPN2 HMX3 HMX3 OXTR OXTR VMP1 VMP1 EPN1 EPN1 LOC100601152 LOC100601152 AGRP AGRP TPPP3 TPPP3 GHRL GHRL PLA2G4C PLA2G4C TGFBR2 TGFBR2 LOC100591987 LOC100591987 RECK RECK HAVCR2 HAVCR2 OVGP1 OVGP1 SLC6A4 SLC6A4 SOD1 SOD1 LIF LIF SCGB1A1 SCGB1A1 UCN UCN TCF23 TCF23 ACSL4 ACSL4 FKBP4 FKBP4 GIP GIP PZP PZP TLE6 TLE6 FOSB FOSB PCSK5 PCSK5 PRL PRL RARA RARA TMED2 TMED2 ITGB4 ITGB4 ATP7A ATP7A CALCA CALCA MMP2 MMP2 MED1 MED1 ADCY7 ADCY7 EDN1 EDN1 BSG BSG KALRN KALRN AR AR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DDR1Discoidin domain receptor tyrosine kinase 1. (913 aa)
LNPEPLeucyl and cystinyl aminopeptidase. (1026 aa)
PMP22Peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system; Belongs to the PMP-22/EMP/MP20 family. (160 aa)
ANGPT2Angiopoietin 2. (496 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
MAFFMAF bZIP transcription factor F. (170 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (339 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
STC1Stanniocalcin 1. (247 aa)
NODALNodal growth differentiation factor. (347 aa)
ACOD1Aconitate decarboxylase 1. (489 aa)
MAGED2MAGE family member D2. (606 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
HSD11B2Hydroxysteroid 11-beta dehydrogenase 2. (445 aa)
IGFBP7Insulin like growth factor binding protein 7. (284 aa)
ENSNLEP00000039759GOLD domain-containing protein. (183 aa)
LOC100580006Uncharacterized protein. (371 aa)
G1S3Q0_NOMLEUncharacterized protein. (114 aa)
AMBPAlpha-1-microglobulin/bikunin precursor. (312 aa)
PAPPAPappalysin 1. (1627 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (551 aa)
ADRA2BG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (391 aa)
CSMD1CUB and Sushi multiple domains 1. (3565 aa)
ENSNLEP00000037562Uncharacterized protein. (419 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (622 aa)
PLA2G6Phospholipase A2 group VI. (805 aa)
LDOC1LDOC1 regulator of NFKB signaling. (145 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
ENSNLEP0000003582260S ribosomal protein L29; Belongs to the eukaryotic ribosomal protein eL29 family. (148 aa)
LOC100597420Uncharacterized protein. (438 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (327 aa)
COL16A1LAM_G_DOMAIN domain-containing protein. (1472 aa)
TROTrophinin. (1411 aa)
PGFPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (225 aa)
THBDThrombomodulin. (568 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (806 aa)
SPHK2Sphingosine kinase 2. (630 aa)
CRHCorticotropin releasing hormone. (196 aa)
TRIM28Tripartite motif containing 28. (808 aa)
CSMD2CUB and Sushi multiple domains 2. (3507 aa)
ENSNLEP00000028388Uncharacterized protein. (141 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
CD38CD38 molecule. (300 aa)
CLIC5Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (412 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. (405 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (379 aa)
CORINCorin, serine peptidase. (1042 aa)
TAC3Tachykinin 3. (121 aa)
ADMAdrenomedullin. (184 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1038 aa)
VDRVitamin D receptor. (427 aa)
ENDOUEndonuclease, poly(U) specific. (411 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
RGS2Regulator of G protein signaling 2. (211 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
G1SB02_NOMLEDUF4939 domain-containing protein. (94 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
ENSNLEP00000025665Uncharacterized protein. (686 aa)
TACR1Tachykinin receptor 1. (406 aa)
PTNPleiotrophin. (172 aa)
TAC1Tachykinin precursor 1. (129 aa)
ARG1Arginase. (322 aa)
DEDDDeath effector domain containing. (347 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CEACAM5Carcinoembryonic antigen related cell adhesion molecule 5. (691 aa)
PRDM1PR/SET domain 1. (825 aa)
KLF1Kruppel like factor 1. (362 aa)
DDOD-aspartate oxidase. (369 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (402 aa)
EPORErythropoietin receptor; Receptor for erythropoietin. (520 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (462 aa)
ASH1LASH1 like histone lysine methyltransferase. (2923 aa)
A1CFAPOBEC1 complementation factor. (595 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
STAT5BSignal transducer and activator of transcription. (650 aa)
UBE2Q1Ubiquitin conjugating enzyme E2 Q1. (422 aa)
PRDM14PR/SET domain 14. (496 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (979 aa)
STOX2Storkhead box 2. (921 aa)
PTGFRProstaglandin F receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
PTAFRPlatelet activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (342 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (381 aa)
SPP1Secreted phosphoprotein 1. (314 aa)
GNASGNAS complex locus. (1038 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
IHHIndian hedgehog signaling molecule. (389 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1050 aa)
FUT7Fucosyltransferase 7. (342 aa)
STSSteroid sulfatase. (583 aa)
LAMB1Laminin subunit beta 1. (1810 aa)
OXTOxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (124 aa)
IGFBP5Insulin like growth factor binding protein 5. (272 aa)
IGFBP2Insulin like growth factor binding protein 2. (325 aa)
PGRUncharacterized protein. (339 aa)
SLC38A3Solute carrier family 38 member 3. (416 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
MMP9Matrix metallopeptidase 9. (692 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (176 aa)
HPGD15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
DSG1Desmoglein 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1046 aa)
FOSL1BZIP domain-containing protein. (271 aa)
EPYCEpiphycan. (322 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
MEN1Menin 1. (614 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (716 aa)
TEAD4TEA domain transcription factor 4. (420 aa)
ENSNLEP00000041273Uncharacterized protein. (190 aa)
ABCC8ATP binding cassette subfamily C member 8. (1569 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1181 aa)
ENSNLEP00000042687Uncharacterized protein. (245 aa)
DAZAP1DAZ associated protein 1. (397 aa)
PRLHRProlactin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (370 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
TEAD3Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (435 aa)
NR2F2Nuclear receptor subfamily 2 group F member 2. (414 aa)
SP3Sp3 transcription factor. (744 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
EDDM3BRNAse_Pc domain-containing protein. (147 aa)
LOC100606651Uncharacterized protein. (502 aa)
RAM2Ribonuclease A M2. (147 aa)
CAPN2Calpain 2; Belongs to the peptidase C2 family. (660 aa)
HMX3H6 family homeobox 3. (357 aa)
OXTROxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (389 aa)
VMP1Uncharacterized protein. (406 aa)
EPN1Epsin 1. (677 aa)
LOC100601152Uncharacterized protein. (457 aa)
AGRPAgouti related neuropeptide. (132 aa)
TPPP3Tubulin polymerization promoting protein family member 3. (176 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
PLA2G4CPhospholipase A2 group IVC. (519 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
LOC100591987Phospholipase A2. (760 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (971 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (302 aa)
OVGP1Oviductal glycoprotein 1; Belongs to the glycosyl hydrolase 18 family. (678 aa)
SLC6A4Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (625 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
SCGB1A1Secretoglobin family 1A member 1. (91 aa)
UCNUrocortin. (124 aa)
TCF23Transcription factor 23. (214 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (711 aa)
FKBP4Peptidylprolyl isomerase. (424 aa)
GIPGastric inhibitory polypeptide. (153 aa)
PZPPZP alpha-2-macroglobulin like. (1475 aa)
TLE6TLE family member 6, subcortical maternal complex member. (553 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1860 aa)
PRLProlactin. (227 aa)
RARARetinoic acid receptor alpha. (458 aa)
TMED2Transmembrane p24 trafficking protein 2. (199 aa)
ITGB4Integrin beta. (1746 aa)
ATP7AATPase copper transporting alpha. (1460 aa)
CALCACalcitonin related polypeptide alpha. (141 aa)
MMP2Matrix metallopeptidase 2. (647 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1558 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (983 aa)
EDN1Endothelin 1. (211 aa)
BSGUncharacterized protein. (345 aa)
KALRNUncharacterized protein. (2931 aa)
ARUncharacterized protein. (392 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
Server load: low (14%) [HD]