STRINGSTRING
TWIST2 TWIST2 BMP6 BMP6 UCMA UCMA TENT5A TENT5A SFRP1 SFRP1 BMP4 BMP4 FFAR4 FFAR4 SNAI2 SNAI2 WNT7B WNT7B NOCT NOCT BMP2 BMP2 BMPR1B BMPR1B NPPC NPPC JAG1 JAG1 DDR2 DDR2 AXIN2 AXIN2 FBXO5 FBXO5 WNT10B WNT10B IL6 IL6 SUFU SUFU TNF TNF SMAD6 SMAD6 HOXA2 HOXA2 ATF4 ATF4 SUCO SUCO TNN TNN GDF10 GDF10 PRKD1 PRKD1 CRIM1 CRIM1 RANBP3L RANBP3L PTCH1 PTCH1 VEGFC VEGFC FGFR2 FGFR2 HEMGN HEMGN BAMBI BAMBI GLI1 GLI1 SCUBE2 SCUBE2 NELL1 NELL1 SEMA4D SEMA4D ACVR1 ACVR1 IL6ST IL6ST TMEM64 TMEM64 WWTR1 WWTR1 FGF23 FGF23 GLI3 GLI3 CTHRC1 CTHRC1 G1QYG1_NOMLE G1QYG1_NOMLE ESRRA ESRRA MEN1 MEN1 ACVR2B ACVR2B FNDC3B FNDC3B SMAD1 SMAD1 RORB RORB HDAC7 HDAC7 SMOC1 SMOC1 FBN2 FBN2 AREG AREG ATRAID ATRAID SMAD3 SMAD3 BMPR2 BMPR2 NOG NOG RIOX1 RIOX1 DDX5 DDX5 GREM2 GREM2 CLIC1 CLIC1 SMAD5 SMAD5 IGF1 IGF1 TRPM4 TRPM4 GDPD2 GDPD2 PPARG PPARG FERMT2 FERMT2 IL6R IL6R CCN4 CCN4 PTK2 PTK2 MEF2C MEF2C TP63 TP63 LTF LTF ENSNLEP00000032543 ENSNLEP00000032543 PPP3CA PPP3CA YAP1 YAP1 LOC100588616 LOC100588616 ENSNLEP00000030331 ENSNLEP00000030331 LOC100605818 LOC100605818 PDLIM7 PDLIM7 CHRD CHRD ENSNLEP00000029616 ENSNLEP00000029616 LRP5L LRP5L ID3 ID3 SOX9 SOX9 BMPR1A BMPR1A PRKACA PRKACA ENSNLEP00000025226 ENSNLEP00000025226 RASSF2 RASSF2 CDK6 CDK6 HGF HGF G1SBN8_NOMLE G1SBN8_NOMLE LOC101176289 LOC101176289 CITED1 CITED1 CTNNB1 CTNNB1 SFRP2 SFRP2 LIMD1 LIMD1 ZHX3 ZHX3 TCIRG1 TCIRG1 LRP5 LRP5 HAND2 HAND2 OSTN OSTN TWSG1 TWSG1 BMP7 BMP7 IGFBP5 IGFBP5 LRP3 LRP3 NOTCH1 NOTCH1 SCUBE3 SCUBE3 REST REST ACVR2A ACVR2A CTNNBIP1 CTNNBIP1 WDR63 WDR63 CCN1 CCN1 GREM1 GREM1 TNFAIP6 TNFAIP6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TWIST2Twist family bHLH transcription factor 2. (160 aa)
BMP6TGF_BETA_2 domain-containing protein. (125 aa)
UCMAUpper zone of growth plate and cartilage matrix associated. (138 aa)
TENT5ATerminal nucleotidyltransferase 5A. (443 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
FFAR4G_PROTEIN_RECEP_F1_2 domain-containing protein. (235 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
NOCTNocturnin. (368 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
NPPCNatriuretic peptide C. (129 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1157 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
AXIN2DIX domain-containing protein. (294 aa)
FBXO5F-box protein 5. (428 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (335 aa)
IL6Uncharacterized protein. (258 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (526 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
SMAD6Mothers against decapentaplegic homolog. (465 aa)
HOXA2Homeobox A2. (376 aa)
ATF4BZIP domain-containing protein. (351 aa)
SUCOSUN domain containing ossification factor. (1373 aa)
TNNTenascin N. (1299 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (477 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa)
CRIM1Cysteine rich transmembrane BMP regulator 1. (967 aa)
RANBP3LRAN binding protein 3 like. (490 aa)
PTCH1Patched 1. (1446 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
FGFR2Fibroblast growth factor receptor. (820 aa)
HEMGNHemogen. (484 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (247 aa)
GLI1GLI family zinc finger 1. (1106 aa)
SCUBE2Signal peptide, CUB domain and EGF like domain containing 2. (954 aa)
NELL1Neural EGFL like 1. (838 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (862 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
TMEM64Transmembrane protein 64. (379 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
GLI3GLI family zinc finger 3. (1502 aa)
CTHRC1Collagen triple helix repeat containing 1. (242 aa)
G1QYG1_NOMLEProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (323 aa)
ESRRAEstrogen related receptor alpha. (422 aa)
MEN1Menin 1. (614 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
RORBRAR related orphan receptor B. (470 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1004 aa)
SMOC1SPARC related modular calcium binding 1. (438 aa)
FBN2Fibrillin 2. (2858 aa)
AREGEGF-like domain-containing protein. (274 aa)
ATRAIDAll-trans retinoic acid induced differentiation factor. (271 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
RIOX1Bifunctional lysine-specific demethylase and histidyl-hydroxylase; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. (622 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
GREM2Gremlin. (168 aa)
CLIC1Uncharacterized protein. (188 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
IGF1IlGF domain-containing protein. (196 aa)
TRPM4Uncharacterized protein. (1010 aa)
GDPD2Glycerophosphodiester phosphodiesterase domain containing 2. (590 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
FERMT2Fermitin family member 2. (693 aa)
IL6RInterleukin 6 receptor. (420 aa)
CCN4Cellular communication network factor 4. (318 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1099 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
LTFUncharacterized protein. (453 aa)
ENSNLEP00000032543Uncharacterized protein. (168 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
YAP1Uncharacterized protein. (418 aa)
LOC100588616Runt domain-containing protein. (504 aa)
ENSNLEP00000030331Uncharacterized protein. (367 aa)
LOC100605818BZIP domain-containing protein. (347 aa)
PDLIM7Uncharacterized protein. (368 aa)
CHRDChordin. (867 aa)
ENSNLEP00000029616RGS domain-containing protein. (169 aa)
LRP5LUncharacterized protein. (150 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
SOX9SRY-box transcription factor 9. (510 aa)
BMPR1ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
PRKACAProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (294 aa)
ENSNLEP00000025226Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (244 aa)
RASSF2Ras-associating domain-containing protein. (451 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
G1SBN8_NOMLEChloride intracellular channel protein; Belongs to the chloride channel CLIC family. (247 aa)
LOC101176289Uncharacterized protein. (244 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
CTNNB1Catenin beta 1. (781 aa)
SFRP2Secreted frizzled related protein 2. (280 aa)
LIMD1LIM domains containing 1. (676 aa)
ZHX3Zinc fingers and homeoboxes 3. (968 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (832 aa)
LRP5LDL receptor related protein 5. (1510 aa)
HAND2Heart and neural crest derivatives expressed 2. (198 aa)
OSTNOsteocrin. (133 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
BMP7Bone morphogenetic protein 7. (430 aa)
IGFBP5Insulin like growth factor binding protein 5. (272 aa)
LRP3LDL receptor related protein 3. (770 aa)
NOTCH1Notch receptor 1. (2451 aa)
SCUBE3Signal peptide, CUB domain and EGF like domain containing 3. (910 aa)
RESTRE1 silencing transcription factor. (1097 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
WDR63WD repeat domain 63. (880 aa)
CCN1Cellular communication network factor 1. (317 aa)
GREM1CTCK domain-containing protein. (143 aa)
TNFAIP6TNF alpha induced protein 6. (277 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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