(42 nodes) Positive regulation of Notch signaling pathway network (Nomascus leucogenys)

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Your Input:
	TM2D3	TM2 domain containing 3. (252 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1040 aa)
	IL6ST	Interleukin 6 signal transducer. (918 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (692 aa)
	NOS3	Nitric oxide synthase; Produces nitric oxide (NO). (1128 aa)
	PDCD10	Programmed cell death 10. (212 aa)
	CCN3	Cellular communication network factor 3. (357 aa)
	POGLUT1	Protein O-glucosyltransferase 1. (392 aa)
	SLC35C2	Solute carrier family 35 member C2. (365 aa)
	GSX2	GS homeobox 2. (294 aa)
	NOTCH1	Notch receptor 1. (2451 aa)
	KIT	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (969 aa)
	BMP2K	BMP2 inducible kinase. (1143 aa)
	ZMIZ1	Zinc finger MIZ-type containing 1. (1067 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	MESP1	Uncharacterized protein. (170 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1157 aa)
	MFNG	Beta-1,3-N-acetylglucosaminyltransferase. (320 aa)
	GATA5	GATA binding protein 5. (363 aa)
	JAG2	Jagged canonical Notch ligand 2. (1238 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
	NEPRO	Nucleolus and neural progenitor protein. (543 aa)
	ASCL1	Achaete-scute family bHLH transcription factor 1. (235 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (737 aa)
	AAK1	AP2 associated kinase 1. (946 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	ROBO2	Roundabout guidance receptor 2. (1199 aa)
	TM2D2	TM2 domain-containing protein. (171 aa)
	TSPAN14	Tetraspanin. (270 aa)
	YAP1	Uncharacterized protein. (418 aa)
	ENSNLEP00000032543	Uncharacterized protein. (168 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	LFNG	Uncharacterized protein. (340 aa)
	FKBP14	Peptidylprolyl isomerase. (211 aa)
	ROBO1	Roundabout guidance receptor 1. (1651 aa)
	RFNG	Uncharacterized protein. (205 aa)
	ENHO	Energy homeostasis associated. (76 aa)
	CNTN6	Contactin 6. (999 aa)
	EPN2	Epsin 2. (643 aa)
	ITGB1BP1	Integrin subunit beta 1 binding protein 1. (200 aa)
	SRC	Tyrosine-protein kinase. (537 aa)

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASCL1	DLL1	ENSNLEP00000027743	ENSNLEP00000028248	Achaete-scute family bHLH transcription factor 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.609
ASCL1	GSX2	ENSNLEP00000027743	ENSNLEP00000010070	Achaete-scute family bHLH transcription factor 1.	GS homeobox 2.	0.504
CCN3	NOTCH1	ENSNLEP00000005952	ENSNLEP00000010158	Cellular communication network factor 3.	Notch receptor 1.	0.611
CCN3	WNT1	ENSNLEP00000005952	ENSNLEP00000021689	Cellular communication network factor 3.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.485
CNTN6	NOTCH1	ENSNLEP00000042698	ENSNLEP00000010158	Contactin 6.	Notch receptor 1.	0.426
DLL1	ASCL1	ENSNLEP00000028248	ENSNLEP00000027743	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Achaete-scute family bHLH transcription factor 1.	0.609
DLL1	DLL4	ENSNLEP00000028248	ENSNLEP00000004148	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.509
DLL1	JAG1	ENSNLEP00000028248	ENSNLEP00000017624	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.667
DLL1	LFNG	ENSNLEP00000028248	ENSNLEP00000036169	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.724
DLL1	MESP1	ENSNLEP00000028248	ENSNLEP00000014293	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.456
DLL1	MFNG	ENSNLEP00000028248	ENSNLEP00000017986	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Beta-1,3-N-acetylglucosaminyltransferase.	0.465
DLL1	NOTCH1	ENSNLEP00000028248	ENSNLEP00000010158	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.986
DLL1	ROBO2	ENSNLEP00000028248	ENSNLEP00000029373	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Roundabout guidance receptor 2.	0.589
DLL4	DLL1	ENSNLEP00000004148	ENSNLEP00000028248	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.509
DLL4	JAG1	ENSNLEP00000004148	ENSNLEP00000017624	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.530
DLL4	JAG2	ENSNLEP00000004148	ENSNLEP00000019913	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Jagged canonical Notch ligand 2.	0.499
DLL4	NOTCH1	ENSNLEP00000004148	ENSNLEP00000010158	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.992
ENSNLEP00000032543	SRC	ENSNLEP00000032543	ENSNLEP00000048569	Uncharacterized protein.	Tyrosine-protein kinase.	0.772
ENSNLEP00000032543	STAT3	ENSNLEP00000032543	ENSNLEP00000014018	Uncharacterized protein.	Signal transducer and activator of transcription.	0.534
ENSNLEP00000032543	TP63	ENSNLEP00000032543	ENSNLEP00000032932	Uncharacterized protein.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.749

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