STRINGSTRING
PRKD1 PRKD1 CMA1 CMA1 BMPER BMPER GDF2 GDF2 TNN TNN SASH1 SASH1 JAK1 JAK1 GATA4 GATA4 ANGPTL3 ANGPTL3 ANGPT2 ANGPT2 PAK4 PAK4 VASH2 VASH2 GATA2 GATA2 ERAP1 ERAP1 NR2E1 NR2E1 TIE1 TIE1 PRKCA PRKCA G1QHL5_NOMLE G1QHL5_NOMLE FLT1 FLT1 ADM2 ADM2 ADAM12 ADAM12 CYBB CYBB HK2 HK2 CXCR3 CXCR3 SMOC2 SMOC2 CD34 CD34 AGO2 AGO2 CCL11 CCL11 ANGPTL4 ANGPTL4 C3AR1 C3AR1 IL1A IL1A CYSLTR1 CYSLTR1 SPHK1 SPHK1 ITGB2 ITGB2 TBXA2R TBXA2R EMILIN1 EMILIN1 PRKD2 PRKD2 SIRT6 SIRT6 TMIGD2 TMIGD2 G1QSA7_NOMLE G1QSA7_NOMLE EPHA1 EPHA1 MTDH MTDH CDH5 CDH5 NOS3 NOS3 TGFBR2 TGFBR2 GHRL GHRL VEGFB VEGFB RRAS RRAS GRN GRN WARS2 WARS2 GAB1 GAB1 GHSR GHSR SMAD1 SMAD1 EMC10 EMC10 SFRP2 SFRP2 CCR3 CCR3 PLCG1 PLCG1 GATA6 GATA6 EMILIN2 EMILIN2 HYAL1 HYAL1 WNT5A WNT5A ETS1 ETS1 CHRNA7 CHRNA7 SERPINE1 SERPINE1 ANXA3 ANXA3 CCBE1 CCBE1 CCL24 CCL24 CTSH CTSH RLN2 RLN2 HPSE HPSE PIK3CD PIK3CD VEGFD VEGFD ANGPT4 ANGPT4 LOC100592336 LOC100592336 FGF1 FGF1 ECM1 ECM1 DDAH1 DDAH1 GREM1 GREM1 ISL1 ISL1 JUP JUP F3 F3 TERT TERT TLR3 TLR3 STAT3 STAT3 ZC3H12A ZC3H12A SEMA5A SEMA5A RAMP2 RAMP2 SIRT1 SIRT1 APLNR APLNR ABL1 ABL1 SLC39A12 SLC39A12 AQP1 AQP1 HIF1A HIF1A JMJD8 JMJD8 NTRK1 NTRK1 CXCL8 CXCL8 HMOX1 HMOX1 IL1B IL1B KDR KDR THBS1 THBS1 PRKCB PRKCB XBP1 XBP1 NFE2L2 NFE2L2 EMP2 EMP2 BRCA1 BRCA1 TJP1 TJP1 CX3CR1 CX3CR1 MYDGF MYDGF PKM PKM RUNX1 RUNX1 ENSNLEP00000041273 ENSNLEP00000041273 RHOB RHOB LOC100593010 LOC100593010 LOC100588959 LOC100588959 HIPK2 HIPK2 FGF2 FGF2 LOC100591323 LOC100591323 TNFSF12 TNFSF12 VEGFA VEGFA IL10 IL10 HSPB6 HSPB6 ENSNLEP00000033205 ENSNLEP00000033205 PGF PGF BTG1 BTG1 CD40 CD40 ITGB3 ITGB3 HIPK1 HIPK1 ENSNLEP00000031077 ENSNLEP00000031077 ZNF304 ZNF304 KLF4 KLF4 LRG1 LRG1 STIM1 STIM1 DLL1 DLL1 ENG ENG NRP1 NRP1 AGGF1 AGGF1 HGF HGF AKT3 AKT3 G1SAU3_NOMLE G1SAU3_NOMLE C5AR1 C5AR1 CHI3L1 CHI3L1 RAPGEF3 RAPGEF3 CELA1 CELA1 ACVRL1 ACVRL1 SP1 SP1 ITGA5 ITGA5 ADM ADM C5 C5 JCAD JCAD VEGFC VEGFC ITGB8 ITGB8 NINJ1 NINJ1 ITGAX ITGAX TEK TEK CYP1B1 CYP1B1 PTK2B PTK2B PTGIS PTGIS NODAL NODAL C3 C3
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query proteins and first shell of interactors
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second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa)
CMA1Chymase 1; Belongs to the peptidase S1 family. (252 aa)
BMPERBMP binding endothelial regulator. (685 aa)
GDF2Growth differentiation factor 2. (429 aa)
TNNTenascin N. (1299 aa)
SASH1SAM and SH3 domain containing 1. (1247 aa)
JAK1Tyrosine-protein kinase. (1149 aa)
GATA4GATA binding protein 4. (443 aa)
ANGPTL3Angiopoietin like 3. (459 aa)
ANGPT2Angiopoietin 2. (496 aa)
PAK4Non-specific serine/threonine protein kinase. (595 aa)
VASH2Uncharacterized protein. (251 aa)
GATA2GATA binding protein 2. (480 aa)
ERAP1Aminopeptidase. (942 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (422 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1142 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
G1QHL5_NOMLEUncharacterized protein; Belongs to the heparin-binding growth factors family. (182 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
ADM2Adrenomedullin 2. (148 aa)
ADAM12ADAM metallopeptidase domain 12. (909 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
HK2Hexokinase 2. (917 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (368 aa)
SMOC2SPARC related modular calcium binding 2. (423 aa)
CD34CD34 molecule. (385 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (847 aa)
CCL11C-C motif chemokine. (97 aa)
ANGPTL4Angiopoietin like 4. (379 aa)
C3AR1Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family. (482 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (247 aa)
CYSLTR1Cysteinyl leukotriene receptor 1. (337 aa)
SPHK1DAGKc domain-containing protein. (398 aa)
ITGB2Integrin beta. (762 aa)
TBXA2RThromboxane A2 receptor; Belongs to the G-protein coupled receptor 1 family. (407 aa)
EMILIN1Elastin microfibril interfacer 1. (1016 aa)
PRKD2Uncharacterized protein. (716 aa)
SIRT6Deacetylase sirtuin-type domain-containing protein. (215 aa)
TMIGD2Transmembrane and immunoglobulin domain containing 2. (262 aa)
G1QSA7_NOMLEUncharacterized protein. (109 aa)
EPHA1EPH receptor A1. (975 aa)
MTDHMetadherin. (582 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (687 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1128 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
RRASRAS related. (217 aa)
GRNGranulin precursor. (593 aa)
WARS2Tryptophanyl tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (360 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
EMC10Uncharacterized protein. (347 aa)
SFRP2Secreted frizzled related protein 2. (280 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (361 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1182 aa)
GATA6Uncharacterized protein. (452 aa)
EMILIN2Elastin microfibril interfacer 2. (1030 aa)
HYAL1Hyaluronidase. (435 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
CHRNA7Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (358 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
ANXA3Annexin. (323 aa)
CCBE1Collagen and calcium binding EGF domains 1. (406 aa)
CCL24C-C motif chemokine ligand 24. (118 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (335 aa)
RLN2Relaxin 2. (185 aa)
HPSEHeparanase. (543 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1077 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
ANGPT4Angiopoietin 4. (480 aa)
LOC100592336PH_3 domain-containing protein. (247 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
ECM1Extracellular matrix protein 1. (568 aa)
DDAH1Dimethylarginine dimethylaminohydrolase 1. (256 aa)
GREM1CTCK domain-containing protein. (143 aa)
ISL1ISL LIM homeobox 1. (349 aa)
JUPJunction plakoglobin. (730 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (295 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (983 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (560 aa)
SEMA5ASemaphorin 5A. (1074 aa)
RAMP2Receptor activity modifying protein 2. (180 aa)
SIRT1Sirtuin 1. (734 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
ABL1Tyrosine-protein kinase. (1006 aa)
SLC39A12Solute carrier family 39 member 12. (691 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
JMJD8Jumonji domain containing 8. (334 aa)
NTRK1Tyrosine-protein kinase receptor. (787 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1367 aa)
THBS1Thrombospondin 1. (1173 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
XBP1BZIP domain-containing protein. (376 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (607 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
BRCA1BRCA1 DNA repair associated. (1884 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1754 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (386 aa)
MYDGFMyeloid derived growth factor. (188 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (530 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (485 aa)
ENSNLEP00000041273Uncharacterized protein. (190 aa)
RHOBRas homolog family member B. (196 aa)
LOC100593010Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (459 aa)
LOC100588959Pyruvate kinase; Belongs to the pyruvate kinase family. (512 aa)
HIPK2Homeodomain interacting protein kinase 2. (1198 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (287 aa)
LOC100591323Uncharacterized protein. (917 aa)
TNFSF12TNF superfamily member 12; Belongs to the tumor necrosis factor family. (249 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (393 aa)
IL10Interleukin 10. (178 aa)
HSPB6Heat shock protein family B (small) member 6; Belongs to the small heat shock protein (HSP20) family. (160 aa)
ENSNLEP00000033205Pyruvate kinase; Belongs to the pyruvate kinase family. (612 aa)
PGFPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (225 aa)
BTG1BTG anti-proliferation factor 1. (171 aa)
CD40TNFR-Cys domain-containing protein. (219 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (806 aa)
HIPK1Homeodomain interacting protein kinase 1. (1142 aa)
ENSNLEP00000031077Neur_chan_LBD domain-containing protein. (158 aa)
ZNF304Zinc finger protein 304. (705 aa)
KLF4Uncharacterized protein. (145 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (347 aa)
STIM1Stromal interaction molecule 1. (818 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (737 aa)
ENGEndoglin. (658 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (901 aa)
AGGF1G-patch domain-containing protein. (679 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
G1SAU3_NOMLEL-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (338 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (350 aa)
CHI3L1Chitinase 3 like 1; Belongs to the glycosyl hydrolase 18 family. (403 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (853 aa)
CELA1Chymotrypsin like elastase 1; Belongs to the peptidase S1 family. (266 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
SP1Sp1 transcription factor. (786 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1038 aa)
ADMAdrenomedullin. (184 aa)
C5Complement C5. (1676 aa)
JCADJunctional cadherin 5 associated. (1354 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (725 aa)
NINJ1Ninjurin 1. (152 aa)
ITGAXIntegrin subunit alpha X; Belongs to the integrin alpha chain family. (1153 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (871 aa)
PTGISProstacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (500 aa)
NODALNodal growth differentiation factor. (347 aa)
C3Complement C3. (1424 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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