(44 nodes) Negative regulation of mitotic nuclear division network (Nomascus leucogenys)

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Your Input:
	BIRC5	Uncharacterized protein. (91 aa)
	BUB1	BUB1 mitotic checkpoint serine/threonine kinase. (896 aa)
	KNTC1	Kinetochore associated 1. (2189 aa)
	BUB1B	BUB1 N-terminal domain-containing protein. (1056 aa)
	SPC25	SPC25 component of NDC80 kinetochore complex. (224 aa)
	RAD21	RAD21 cohesin complex component. (631 aa)
	MTBP	MDM2 binding protein. (904 aa)
	NDC80	NDC80 kinetochore complex component. (642 aa)
	BMP7	Bone morphogenetic protein 7. (430 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3055 aa)
	KLHL22	Kelch like family member 22. (558 aa)
	TOM1L1	Target of myb1 like 1 membrane trafficking protein; Belongs to the TOM1 family. (476 aa)
	TEX14	Testis expressed 14, intercellular bridge forming factor. (1497 aa)
	G1RB97_NOMLE	Uncharacterized protein. (503 aa)
	PSMG2	Proteasome assembly chaperone 2; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. Belongs to the PSMG2 family. (264 aa)
	MAD2L1	Mitotic arrest deficient 2 like 1. (205 aa)
	IK	IK cytokine. (537 aa)
	MAD2L2	HORMA domain-containing protein. (124 aa)
	TRIP13	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (432 aa)
	APC	APC regulator of WNT signaling pathway. (2844 aa)
	ZWINT	ZW10 interacting kinetochore protein. (281 aa)
	PLK1	Serine/threonine-protein kinase PLK. (568 aa)
	TTK	TTK protein kinase. (852 aa)
	SPC24	SPC24 component of NDC80 kinetochore complex. (166 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	ZWILCH	Zwilch kinetochore protein. (552 aa)
	CDC20	Cell division cycle 20. (498 aa)
	ZW10	Zw10 kinetochore protein. (699 aa)
	ENSNLEP00000046801	Protein kinase domain-containing protein. (214 aa)
	FBXO5	F-box protein 5. (428 aa)
	ENSNLEP00000042051	Uncharacterized protein. (448 aa)
	CHEK1	Checkpoint kinase 1. (492 aa)
	ENSNLEP00000039204	Uncharacterized protein. (233 aa)
	AURKB	Uncharacterized protein. (123 aa)
	SPDL1	Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. (595 aa)
	NME6	Nucleoside diphosphate kinase. (194 aa)
	ENSNLEP00000030327	HORMA domain-containing protein. (98 aa)
	ENSNLEP00000028618	WD_REPEATS_REGION domain-containing protein. (470 aa)
	ENSNLEP00000026532	Uncharacterized protein. (390 aa)
	ENSNLEP00000025494	Uncharacterized protein. (164 aa)
	HASPIN	Histone H3 associated protein kinase. (790 aa)
	TPR	Translocated promoter region, nuclear basket protein. (2354 aa)
	NUF2	NUF2 component of NDC80 kinetochore complex. (464 aa)
	CENPF	Centromere protein F. (3113 aa)

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APC	BUB1	ENSNLEP00000014057	ENSNLEP00000001609	APC regulator of WNT signaling pathway.	BUB1 mitotic checkpoint serine/threonine kinase.	0.556
ATM	CHEK1	ENSNLEP00000008823	ENSNLEP00000040376	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Checkpoint kinase 1.	0.890
ATM	PLK1	ENSNLEP00000008823	ENSNLEP00000014587	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Serine/threonine-protein kinase PLK.	0.556
AURKB	BIRC5	ENSNLEP00000038564	ENSNLEP00000000106	Uncharacterized protein.	Uncharacterized protein.	0.973
AURKB	BUB1	ENSNLEP00000038564	ENSNLEP00000001609	Uncharacterized protein.	BUB1 mitotic checkpoint serine/threonine kinase.	0.880
AURKB	BUB1B	ENSNLEP00000038564	ENSNLEP00000003290	Uncharacterized protein.	BUB1 N-terminal domain-containing protein.	0.836
AURKB	CDC20	ENSNLEP00000038564	ENSNLEP00000016408	Uncharacterized protein.	Cell division cycle 20.	0.810
AURKB	CENPF	ENSNLEP00000038564	ENSNLEP00000017505	Uncharacterized protein.	Centromere protein F.	0.626
AURKB	ENSNLEP00000028618	ENSNLEP00000038564	ENSNLEP00000028618	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.810
AURKB	ENSNLEP00000030327	ENSNLEP00000038564	ENSNLEP00000030327	Uncharacterized protein.	HORMA domain-containing protein.	0.714
AURKB	ENSNLEP00000046801	ENSNLEP00000038564	ENSNLEP00000046801	Uncharacterized protein.	Protein kinase domain-containing protein.	0.793
AURKB	HASPIN	ENSNLEP00000038564	ENSNLEP00000022714	Uncharacterized protein.	Histone H3 associated protein kinase.	0.499
AURKB	KNTC1	ENSNLEP00000038564	ENSNLEP00000002615	Uncharacterized protein.	Kinetochore associated 1.	0.414
AURKB	MAD2L1	ENSNLEP00000038564	ENSNLEP00000011078	Uncharacterized protein.	Mitotic arrest deficient 2 like 1.	0.714
AURKB	NDC80	ENSNLEP00000038564	ENSNLEP00000008374	Uncharacterized protein.	NDC80 kinetochore complex component.	0.821
AURKB	NUF2	ENSNLEP00000038564	ENSNLEP00000017832	Uncharacterized protein.	NUF2 component of NDC80 kinetochore complex.	0.676
AURKB	PLK1	ENSNLEP00000038564	ENSNLEP00000014587	Uncharacterized protein.	Serine/threonine-protein kinase PLK.	0.793
AURKB	RAD21	ENSNLEP00000038564	ENSNLEP00000005872	Uncharacterized protein.	RAD21 cohesin complex component.	0.418
AURKB	SPC24	ENSNLEP00000038564	ENSNLEP00000015160	Uncharacterized protein.	SPC24 component of NDC80 kinetochore complex.	0.447
AURKB	TRIP13	ENSNLEP00000038564	ENSNLEP00000013363	Uncharacterized protein.	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family.	0.484

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