STRINGSTRING
NOS3 NOS3 GCHFR GCHFR POR POR ACP5 ACP5 GCH1 GCH1 TICAM1 TICAM1 MTARC1 MTARC1 MARC2 MARC2 CYP1B1 CYP1B1 NOS2 NOS2 CPS1 CPS1 AKT1 AKT1 SPR SPR CAV1 CAV1 TLR6 TLR6 RORA RORA DDAH2 DDAH2 CYB5B CYB5B LOC100595503 LOC100595503 ARG2 ARG2 NOS1 NOS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1128 aa)
GCHFRGTP cyclohydrolase I feedback regulator. (84 aa)
PORNADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (680 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (325 aa)
GCH1GTP cyclohydrolase 1. (250 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (691 aa)
MTARC1MOSC domain-containing protein. (337 aa)
MARC2Mitochondrial amidoxime reducing component 2. (335 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1153 aa)
CPS1Carbamoyl-phosphate synthase 1. (1506 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
SPRSepiapterin reductase. (261 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
TLR6TIR domain-containing protein. (472 aa)
RORARAR related orphan receptor A. (555 aa)
DDAH2Dimethylarginine dimethylaminohydrolase 2. (287 aa)
CYB5BCytochrome b5 type B; Belongs to the cytochrome b5 family. (150 aa)
LOC100595503FAD-binding FR-type domain-containing protein. (276 aa)
ARG2Arginase. (354 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1425 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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