STRINGSTRING
ACVRL1 ACVRL1 CITED1 CITED1 SMAD2 SMAD2 LDLRAD4 LDLRAD4 PML PML SKIL SKIL PMEPA1 PMEPA1 PAX6 PAX6 SMAD3 SMAD3 TGFBR1 TGFBR1 HIPK2 HIPK2 MEF2A MEF2A SAV1 SAV1 PPARG PPARG ENSNLEP00000036789 ENSNLEP00000036789 FERMT2 FERMT2 DROSHA DROSHA YY1 YY1 TCF12 TCF12 ENSNLEP00000029616 ENSNLEP00000029616 SNW1 SNW1 ENSNLEP00000027025 ENSNLEP00000027025 USP9X USP9X BMPR1A BMPR1A ENSNLEP00000048128 ENSNLEP00000048128 SMURF1 SMURF1 ACVR1 ACVR1 RGCC RGCC ZC3H3 ZC3H3 SMAD9 SMAD9 G1QSA7_NOMLE G1QSA7_NOMLE INTS8 INTS8 TGFBR2 TGFBR2 TRIM33 TRIM33 MEN1 MEN1 SMAD1 SMAD1 CTNNB1 CTNNB1 COL3A1 COL3A1 COL5A2 COL5A2 STUB1 STUB1 TGFBR3 TGFBR3 ZMIZ1 ZMIZ1 TGFBRAP1 TGFBRAP1 FOS FOS MYOCD MYOCD SKOR2 SKOR2 SMAD6 SMAD6 SMAD7 SMAD7 AXIN1 AXIN1 FOXH1 FOXH1 SMAD4 SMAD4 ANKRD1 ANKRD1 SKOR1 SKOR1 PPM1A PPM1A PARP1 PARP1 CREB3L1 CREB3L1 BMP2 BMP2 BMPR1B BMPR1B JUN JUN AXIN2 AXIN2 SMURF2 SMURF2 CITED2 CITED2 GATA4 GATA4 COL1A2 COL1A2 RANBP3 RANBP3 RANBP3L RANBP3L TGFB1I1 TGFB1I1 DAB2 DAB2 USP15 USP15 IPO7 IPO7 ACVR1B ACVR1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (306 aa)
PMLUncharacterized protein. (873 aa)
SKILSKI like proto-oncogene. (683 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (274 aa)
PAX6Uncharacterized protein. (456 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
HIPK2Homeodomain interacting protein kinase 2. (1198 aa)
MEF2AMyocyte enhancer factor 2A. (509 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
ENSNLEP00000036789SKIP_SNW domain-containing protein. (443 aa)
FERMT2Fermitin family member 2. (693 aa)
DROSHADrosha ribonuclease III. (1324 aa)
YY1Uncharacterized protein. (311 aa)
TCF12Transcription factor 12. (706 aa)
ENSNLEP00000029616RGS domain-containing protein. (169 aa)
SNW1SNW domain containing 1. (571 aa)
ENSNLEP00000027025PPM-type phosphatase domain-containing protein. (340 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2507 aa)
BMPR1ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
ENSNLEP00000048128Uncharacterized protein. (950 aa)
SMURF1E3 ubiquitin-protein ligase. (749 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
RGCCRegulator of cell cycle. (137 aa)
ZC3H3Zinc finger CCCH-type containing 3. (939 aa)
SMAD9Mothers against decapentaplegic homolog. (467 aa)
G1QSA7_NOMLEUncharacterized protein. (109 aa)
INTS8Integrator complex subunit 8. (988 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
TRIM33Tripartite motif containing 33. (1002 aa)
MEN1Menin 1. (614 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
CTNNB1Catenin beta 1. (781 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
COL5A2Collagen type V alpha 2 chain. (1499 aa)
STUB1Uncharacterized protein. (231 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1067 aa)
TGFBRAP1Transforming growth factor beta receptor associated protein 1. (860 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MYOCDMyocardin. (986 aa)
SKOR2c-SKI_SMAD_bind domain-containing protein. (295 aa)
SMAD6Mothers against decapentaplegic homolog. (465 aa)
SMAD7Mothers against decapentaplegic homolog. (376 aa)
AXIN1Axin 1. (837 aa)
FOXH1Forkhead box H1. (366 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ANKRD1Ankyrin repeat domain 1. (286 aa)
SKOR1c-SKI_SMAD_bind domain-containing protein. (961 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (948 aa)
CREB3L1BZIP domain-containing protein. (467 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
JUNBZIP domain-containing protein; Belongs to the bZIP family. (305 aa)
AXIN2DIX domain-containing protein. (294 aa)
SMURF2E3 ubiquitin-protein ligase. (745 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
GATA4GATA binding protein 4. (443 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
RANBP3RAN binding protein 3. (575 aa)
RANBP3LRAN binding protein 3 like. (490 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (460 aa)
DAB2DAB adaptor protein 2. (749 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
IPO7Importin 7. (1038 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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