STRINGSTRING
MAP4K4 MAP4K4 LZTR1 LZTR1 RASAL1 RASAL1 MCF2L MCF2L OPHN1 OPHN1 STARD8 STARD8 CRK CRK STARD13 STARD13 CYTH3 CYTH3 CADM4 CADM4 KCTD10 KCTD10 G1QMG8_NOMLE G1QMG8_NOMLE TRIM67 TRIM67 TNFAIP1 TNFAIP1 P2RY10 P2RY10 PSD4 PSD4 G1QRG0_NOMLE G1QRG0_NOMLE ARHGAP35 ARHGAP35 ADGRG1 ADGRG1 PSD3 PSD3 EPS8L3 EPS8L3 CSF1 CSF1 ERBIN ERBIN ARHGDIB ARHGDIB ABRA ABRA CCDC125 CCDC125 PIK3CB PIK3CB RASIP1 RASIP1 IQSEC1 IQSEC1 ARHGEF28 ARHGEF28 SYDE1 SYDE1 KRAS KRAS RASAL3 RASAL3 FLOT1 FLOT1 NOTCH2 NOTCH2 KITLG KITLG MYO9B MYO9B RTN4R RTN4R MAPRE2 MAPRE2 STK19 STK19 COL3A1 COL3A1 FBXO8 FBXO8 ARFGEF2 ARFGEF2 RALBP1 RALBP1 RIPOR3 RIPOR3 RDX RDX APOC3 APOC3 CBL CBL RASA3 RASA3 GPR18 GPR18 SH2B2 SH2B2 NOTCH1 NOTCH1 RASA4B RASA4B EPS8L2 EPS8L2 KANK1 KANK1 RASGRF1 RASGRF1 PIK3CG PIK3CG ITGA3 ITGA3 PSD2 PSD2 ARHGAP24 ARHGAP24 ARAP3 ARAP3 SPRY4 SPRY4 MFN2 MFN2 SYDE2 SYDE2 STMN3 STMN3 PDGFRB PDGFRB ARHGDIA ARHGDIA DENND4B DENND4B EPS8L1 EPS8L1 ARFGEF1 ARFGEF1 AKAP13 AKAP13 NET1 NET1 RASGRP1 RASGRP1 EPO EPO PPP2CB PPP2CB KANK2 KANK2 ABL1 ABL1 F2RL2 F2RL2 F2R F2R PLCE1 PLCE1 RASGRF2 RASGRF2 FLCN FLCN RASA1 RASA1 TGFB2 TGFB2 MADD MADD SH3BP1 SH3BP1 ARHGEF10 ARHGEF10 GBF1 GBF1 MYOC MYOC LRRD1 LRRD1 MMD2 MMD2 RALGPS2 RALGPS2 ABL2 ABL2 SHOC2 SHOC2 RAC1 RAC1 RASGEF1A RASGEF1A LOC100590915 LOC100590915 SYNPO2L SYNPO2L FBP1 FBP1 RASGRP4 RASGRP4 GPR65 GPR65 ARRB1 ARRB1 DENND1A DENND1A ABCA1 ABCA1 ARHGEF25 ARHGEF25 RALGPS1 RALGPS1 LPAR1 LPAR1 KIF14 KIF14 KBTBD6 KBTBD6 KBTBD7 KBTBD7 SPRY3 SPRY3 LPAR4 LPAR4 GPR174 GPR174 ITPKB ITPKB LOC100581805 LOC100581805 F11R F11R SSX2IP SSX2IP KCTD13 KCTD13 RASA2 RASA2 HEG1 HEG1 PSD PSD ENSNLEP00000024537 ENSNLEP00000024537 LPAR6 LPAR6 F2RL1 F2RL1 GPR4 GPR4 MET MET NRP1 NRP1 SYNGAP1 SYNGAP1 CDC42SE2 CDC42SE2 AUTS2 AUTS2 SPRY1 SPRY1 ENSNLEP00000027513 ENSNLEP00000027513 SPRY2 SPRY2 ENSNLEP00000027935 ENSNLEP00000027935 ARHGEF2 ARHGEF2 DNM2 DNM2 ENSNLEP00000028972 ENSNLEP00000028972 FGF10 FGF10 ARHGAP17 ARHGAP17 CYTH1 CYTH1 RABL3 RABL3 ARHGAP44 ARHGAP44 GPR17 GPR17 DENND4A DENND4A ENSNLEP00000031417 ENSNLEP00000031417 SMIM10L1 SMIM10L1 ARF6 ARF6 LRRC59 LRRC59 GABARAP GABARAP CYTH2 CYTH2 ARFGAP1 ARFGAP1 DLC1 DLC1 ENSNLEP00000034935 ENSNLEP00000034935 RABGEF1 RABGEF1 STAMBP STAMBP RIT2 RIT2 CYTH4 CYTH4 GPR55 GPR55 ROBO1 ROBO1 BCL6 BCL6 RGL2 RGL2 CDC42SE1 CDC42SE1 NF1 NF1 GIT2 GIT2 ENSNLEP00000040991 ENSNLEP00000040991 DENND4C DENND4C GIT1 GIT1 EPHB2 EPHB2 ENSNLEP00000042609 ENSNLEP00000042609 RIPOR1 RIPOR1 SCAI SCAI SGSM3 SGSM3 ADRA1A ADRA1A ENSNLEP00000044122 ENSNLEP00000044122 DAB2IP DAB2IP IGF1 IGF1 DENND3 DENND3 NRG1 NRG1 ARFGEF3 ARFGEF3 ARHGAP42 ARHGAP42 CAVIN4 CAVIN4 BCR BCR DGKI DGKI STMN1 STMN1 NTRK1 NTRK1 OGT OGT CUL3 CUL3 ENSNLEP00000047355 ENSNLEP00000047355 MAPKAP1 MAPKAP1 ENSNLEP00000048384 ENSNLEP00000048384 SRC SRC FAM220A FAM220A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAP4K4Mitogen-activated protein kinase kinase kinase kinase 4. (1346 aa)
LZTR1Leucine zipper like transcription regulator 1. (835 aa)
RASAL1RAS protein activator like 1. (776 aa)
MCF2LMCF.2 cell line derived transforming sequence like. (1102 aa)
OPHN1Oligophrenin 1. (802 aa)
STARD8StAR related lipid transfer domain containing 8. (1108 aa)
CRKUncharacterized protein. (252 aa)
STARD13StAR related lipid transfer domain containing 13. (930 aa)
CYTH3Cytohesin 3. (399 aa)
CADM4Cell adhesion molecule 4. (338 aa)
KCTD10Potassium channel tetramerization domain containing 10. (315 aa)
G1QMG8_NOMLESEC7 domain-containing protein. (970 aa)
TRIM67Tripartite motif containing 67. (656 aa)
TNFAIP1TNF alpha induced protein 1. (316 aa)
P2RY10P2Y receptor family member 10. (339 aa)
PSD4Pleckstrin and Sec7 domain containing 4. (1015 aa)
G1QRG0_NOMLEFork-head domain-containing protein. (623 aa)
ARHGAP35Rho GTPase activating protein 35. (1499 aa)
ADGRG1Uncharacterized protein. (542 aa)
PSD3Pleckstrin and Sec7 domain containing 3. (1048 aa)
EPS8L3EPS8 like 3. (582 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
ERBINErbb2 interacting protein. (1418 aa)
ARHGDIBRho GDP dissociation inhibitor beta. (201 aa)
ABRAActin binding Rho activating protein. (381 aa)
CCDC125Coiled-coil domain containing 125. (454 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
RASIP1Ras interacting protein 1. (917 aa)
IQSEC1IQ motif and Sec7 domain 1. (1098 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28. (1731 aa)
SYDE1Synapse defective Rho GTPase homolog 1. (687 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
RASAL3Ras-GAP domain-containing protein. (717 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
NOTCH2Notch receptor 2. (2444 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
MYO9BMyosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2151 aa)
RTN4RReticulon 4 receptor. (473 aa)
MAPRE2Microtubule associated protein RP/EB family member 2. (327 aa)
STK19Serine/threonine kinase 19. (363 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
FBXO8F-box protein 8. (319 aa)
ARFGEF2ADP ribosylation factor guanine nucleotide exchange factor 2. (1785 aa)
RALBP1RalA binding protein 1. (655 aa)
RIPOR3RIPOR family member 3. (918 aa)
RDXRadixin. (604 aa)
APOC3Apolipoprotein C3. (99 aa)
CBLCbl proto-oncogene. (905 aa)
RASA3RAS p21 protein activator 3. (816 aa)
GPR18G protein-coupled receptor 18; Belongs to the G-protein coupled receptor 1 family. (331 aa)
SH2B2Uncharacterized protein. (579 aa)
NOTCH1Notch receptor 1. (2451 aa)
RASA4BRas-GAP domain-containing protein. (727 aa)
EPS8L2EPS8 like 2. (710 aa)
KANK1KN motif and ankyrin repeat domains 1. (1352 aa)
RASGRF1Ras protein specific guanine nucleotide releasing factor 1. (1243 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1050 aa)
PSD2Pleckstrin and Sec7 domain containing 2. (771 aa)
ARHGAP24Rho GTPase activating protein 24. (748 aa)
ARAP3ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3. (1531 aa)
SPRY4Sprouty RTK signaling antagonist 4. (288 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (722 aa)
SYDE2Synapse defective Rho GTPase homolog 2. (1194 aa)
STMN3Stathmin; Belongs to the stathmin family. (180 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
ARHGDIAUncharacterized protein. (162 aa)
DENND4BDENN domain containing 4B. (1433 aa)
EPS8L1EPS8 like 1. (718 aa)
ARFGEF1ADP ribosylation factor guanine nucleotide exchange factor 1. (1849 aa)
AKAP13A-kinase anchoring protein 13. (2761 aa)
NET1Neuroepithelial cell transforming 1. (596 aa)
RASGRP1RAS guanyl releasing protein 1. (785 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
KANK2KN motif and ankyrin repeat domains 2. (788 aa)
ABL1Tyrosine-protein kinase. (1006 aa)
F2RL2Coagulation factor II thrombin receptor like 2; Belongs to the G-protein coupled receptor 1 family. (374 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
PLCE1Phosphoinositide phospholipase C. (2303 aa)
RASGRF2Ras protein specific guanine nucleotide releasing factor 2. (1232 aa)
FLCNFolliculin. (542 aa)
RASA1RAS p21 protein activator 1. (1047 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
MADDMAP kinase activating death domain. (1459 aa)
SH3BP1Uncharacterized protein. (682 aa)
ARHGEF10Rho guanine nucleotide exchange factor 10. (1354 aa)
GBF1Golgi brefeldin A resistant guanine nucleotide exchange factor 1. (1859 aa)
MYOCMyocilin. (526 aa)
LRRD1Leucine rich repeats and death domain containing 1. (860 aa)
MMD2Monocyte to macrophage differentiation associated 2. (270 aa)
RALGPS2Ral GEF with PH domain and SH3 binding motif 2. (564 aa)
ABL2Tyrosine-protein kinase. (1182 aa)
SHOC2SHOC2 leucine rich repeat scaffold protein. (582 aa)
RAC1Rac family small GTPase 1. (187 aa)
RASGEF1ARasGEF domain family member 1A. (449 aa)
LOC100590915SEC7 domain-containing protein. (1316 aa)
SYNPO2LSynaptopodin 2 like. (978 aa)
FBP1Fructose-bisphosphatase 1. (281 aa)
RASGRP4RAS guanyl releasing protein 4. (673 aa)
GPR65G protein-coupled receptor 65; Belongs to the G-protein coupled receptor 1 family. (337 aa)
ARRB1Arrestin beta 1. (418 aa)
DENND1ADENN domain containing 1A. (1007 aa)
ABCA1ATP binding cassette subfamily A member 1. (2254 aa)
ARHGEF25Uncharacterized protein. (616 aa)
RALGPS1Ral GEF with PH domain and SH3 binding motif 1. (557 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
KIF14Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1648 aa)
KBTBD6Kelch repeat and BTB domain containing 6. (677 aa)
KBTBD7Kelch repeat and BTB domain containing 7. (684 aa)
SPRY3Sprouty RTK signaling antagonist 3. (288 aa)
LPAR4Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family. (370 aa)
GPR174G protein-coupled receptor 174. (333 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (948 aa)
LOC100581805Uncharacterized protein. (1144 aa)
F11RF11 receptor. (299 aa)
SSX2IPSSX family member 2 interacting protein. (614 aa)
KCTD13Potassium channel tetramerization domain containing 13. (329 aa)
RASA2RAS p21 protein activator 2. (849 aa)
HEG1Heart development protein with EGF like domains 1. (1194 aa)
PSDUncharacterized protein. (645 aa)
ENSNLEP00000024537A20-type domain-containing protein. (112 aa)
LPAR6Lysophosphatidic acid receptor 6; Belongs to the G-protein coupled receptor 1 family. (344 aa)
F2RL1F2R like trypsin receptor 1. (397 aa)
GPR4G protein-coupled receptor 4; Belongs to the G-protein coupled receptor 1 family. (362 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (901 aa)
SYNGAP1Ras-GAP domain-containing protein. (1226 aa)
CDC42SE2CDC42 small effector 2. (84 aa)
AUTS2Activator of transcription and developmental regulator AUTS2. (1259 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
ENSNLEP00000027513Uncharacterized protein. (154 aa)
SPRY2Sprouty RTK signaling antagonist 2. (338 aa)
ENSNLEP00000027935Uncharacterized protein. (181 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1031 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (770 aa)
ENSNLEP00000028972Uncharacterized protein. (122 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ARHGAP17Rho GTPase activating protein 17. (881 aa)
CYTH1Uncharacterized protein. (344 aa)
RABL3RAB, member of RAS oncogene family like 3. (236 aa)
ARHGAP44Rho GTPase activating protein 44. (792 aa)
GPR17G protein-coupled receptor 17; Belongs to the G-protein coupled receptor 1 family. (366 aa)
DENND4ADENN domain containing 4A. (1876 aa)
ENSNLEP00000031417Nsp1_C domain-containing protein. (440 aa)
SMIM10L1Small integral membrane protein 10 like 1. (68 aa)
ARF6Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (175 aa)
LRRC59Leucine rich repeat containing 59. (307 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
CYTH2Uncharacterized protein. (400 aa)
ARFGAP1ADP ribosylation factor GTPase activating protein 1. (414 aa)
DLC1DLC1 Rho GTPase activating protein. (1528 aa)
ENSNLEP00000034935Uncharacterized protein. (310 aa)
RABGEF1RAB guanine nucleotide exchange factor 1. (497 aa)
STAMBPSTAM binding protein. (424 aa)
RIT2Ras like without CAAX 2. (217 aa)
CYTH4Cytohesin 4. (372 aa)
GPR55G protein-coupled receptor 55. (319 aa)
ROBO1Roundabout guidance receptor 1. (1651 aa)
BCL6BCL6 transcription repressor. (706 aa)
RGL2Ral guanine nucleotide dissociation stimulator like 2. (766 aa)
CDC42SE1CDC42 small effector 1. (79 aa)
NF1Neurofibromin 1. (2839 aa)
GIT2GIT ArfGAP 2. (760 aa)
ENSNLEP00000040991Uncharacterized protein. (69 aa)
DENND4CDENN domain containing 4C. (1958 aa)
GIT1GIT ArfGAP 1. (772 aa)
EPHB2EPH receptor B2. (1015 aa)
ENSNLEP00000042609Uncharacterized protein. (168 aa)
RIPOR1RHO family interacting cell polarization regulator 1. (1208 aa)
SCAISuppressor of cancer cell invasion. (607 aa)
SGSM3Small G protein signaling modulator 3. (684 aa)
ADRA1AAdrenoceptor alpha 1A. (470 aa)
ENSNLEP00000044122Uncharacterized protein. (298 aa)
DAB2IPDAB2 interacting protein. (1159 aa)
IGF1IlGF domain-containing protein. (196 aa)
DENND3DENN domain containing 3. (1234 aa)
NRG1Neuregulin 1. (713 aa)
ARFGEF3ARFGEF family member 3. (2177 aa)
ARHGAP42Rho GTPase activating protein 42. (867 aa)
CAVIN4Caveolae associated protein 4. (357 aa)
BCRBCR activator of RhoGEF and GTPase. (1271 aa)
DGKIDiacylglycerol kinase. (1026 aa)
STMN1Stathmin; Belongs to the stathmin family. (172 aa)
NTRK1Tyrosine-protein kinase receptor. (787 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1024 aa)
CUL3Cullin 3; Belongs to the cullin family. (744 aa)
ENSNLEP00000047355Rho-GAP domain-containing protein. (519 aa)
MAPKAP1MAPK associated protein 1. (523 aa)
ENSNLEP00000048384Rho-GAP domain-containing protein. (552 aa)
SRCTyrosine-protein kinase. (537 aa)
FAM220AUncharacterized protein. (70 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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