STRINGSTRING
JAK1 JAK1 SLC1A3 SLC1A3 KDM5B KDM5B CPT1A CPT1A EHMT2 EHMT2 UROS UROS ATP7A ATP7A ZC3H8 ZC3H8 AOC1 AOC1 PLA2G4F PLA2G4F RSRC1 RSRC1 HYAL3 HYAL3 HYAL1 HYAL1 HYAL2 HYAL2 CBL CBL ETS1 ETS1 CASP9 CASP9 ALPL ALPL JAK2 JAK2 GFER GFER SLC9A1 SLC9A1 CIITA CIITA SRD5A1 SRD5A1 AOC3 AOC3 PPP2CB PPP2CB CYB5R4 CYB5R4 ENSNLEP00000040693 ENSNLEP00000040693 ENDOG ENDOG PLA2G4A PLA2G4A CCR4 CCR4 CDKN1B CDKN1B HSP90AA1 HSP90AA1 ENSNLEP00000026090 ENSNLEP00000026090 EZH2 EZH2 KDM1A KDM1A KAT7 KAT7 MEF2C MEF2C CASP8 CASP8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
JAK1Tyrosine-protein kinase. (1149 aa)
SLC1A3Amino acid transporter. (542 aa)
KDM5BLysine demethylase 5B. (1529 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (680 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1122 aa)
UROSUroporphyrinogen III synthase. (265 aa)
ATP7AATPase copper transporting alpha. (1460 aa)
ZC3H8Zinc finger CCCH-type containing 8. (294 aa)
AOC1Amine oxidase. (681 aa)
PLA2G4FPhospholipase A2. (850 aa)
RSRC1Arginine and serine rich coiled-coil 1. (334 aa)
HYAL3Hyaluronidase-3; Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Belongs to the glycosyl hydrolase 56 family. (417 aa)
HYAL1Hyaluronidase. (435 aa)
HYAL2Hyaluronidase. (473 aa)
CBLCbl proto-oncogene. (905 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (426 aa)
ALPLAlkaline phosphatase. (524 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
GFERSulfhydryl oxidase. (205 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (809 aa)
CIITANACHT domain-containing protein. (1329 aa)
SRD5A13-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (259 aa)
AOC3Amine oxidase. (763 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
CYB5R4Cytochrome b5 reductase 4. (521 aa)
ENSNLEP00000040693Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (405 aa)
ENDOGEndonuclease. (278 aa)
PLA2G4APhospholipase A2. (749 aa)
CCR4C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (360 aa)
CDKN1BUncharacterized protein. (204 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (853 aa)
ENSNLEP000000260903-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (258 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (759 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (561 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (538 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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