STRINGSTRING
GRK5 GRK5 ERBB2 ERBB2 MAP4K1 MAP4K1 NEK6 NEK6 SRC SRC MARK2 MARK2 HTATIP2 HTATIP2 WNK2 WNK2 CLK2 CLK2 NTRK1 NTRK1 TAOK1 TAOK1 TRIM24 TRIM24 MUSK MUSK IGF1R IGF1R KDR KDR MEX3B MEX3B ENSNLEP00000042936 ENSNLEP00000042936 CAMK2A CAMK2A EIF2AK2 EIF2AK2 TAOK2 TAOK2 EPHA4 EPHA4 CAMKK2 CAMKK2 ENSNLEP00000041863 ENSNLEP00000041863 THY1 THY1 FYN FYN VRK2 VRK2 LMTK2 LMTK2 MARK3 MARK3 LOC100593010 LOC100593010 MAK MAK CAMK2D CAMK2D ENSNLEP00000039390 ENSNLEP00000039390 PAK1 PAK1 PASK PASK AURKB AURKB STK26 STK26 EEF2K EEF2K ENSNLEP00000036861 ENSNLEP00000036861 EIF2AK4 EIF2AK4 STK24 STK24 EGFR EGFR ULK2 ULK2 PTK2 PTK2 MTOR MTOR FGR FGR CLK1 CLK1 ATP13A2 ATP13A2 ENSNLEP00000031088 ENSNLEP00000031088 TRIM28 TRIM28 MKNK1 MKNK1 PTK6 PTK6 STK16 STK16 EPHA8 EPHA8 AAK1 AAK1 STK4 STK4 AKT1 AKT1 OXSR1 OXSR1 GSK3B GSK3B ENSNLEP00000026081 ENSNLEP00000026081 ATR ATR DAPK2 DAPK2 PRKACA PRKACA FGFR3 FGFR3 DYRK1A DYRK1A PINK1 PINK1 CDK12 CDK12 PIKFYVE PIKFYVE UHMK1 UHMK1 MOS MOS PTPRC PTPRC LRRK2 LRRK2 ACVR1B ACVR1B ATG101 ATG101 MAP3K12 MAP3K12 STK33 STK33 MINK1 MINK1 TXK TXK FGFR2 FGFR2 MYO3A MYO3A TEK TEK PTK2B PTK2B WNK3 WNK3 AATK AATK CLK4 CLK4 PRKD1 PRKD1 RIPK3 RIPK3 ALK ALK TSSK4 TSSK4 SLK SLK ERN1 ERN1 ULK3 ULK3 CSK CSK DDR2 DDR2 CLK3 CLK3 RIOK2 RIOK2 DYRK1B DYRK1B HIPK4 HIPK4 MAP3K10 MAP3K10 STK25 STK25 ROS1 ROS1 INSRR INSRR FGFR4 FGFR4 ABL1 ABL1 TTK TTK FGFR1 FGFR1 FES FES EPHB4 EPHB4 CAMK4 CAMK4 FER FER PIM1 PIM1 RIPK1 RIPK1 PDGFRB PDGFRB CSF1R CSF1R SRMS SRMS HCK HCK MYLK2 MYLK2 CDKL5 CDKL5 LOC100592336 LOC100592336 BMX BMX TNK1 TNK1 JAK2 JAK2 PRKG2 PRKG2 ULK1 ULK1 KIT KIT PEAK1 PEAK1 PDGFRA PDGFRA G1R9T9_NOMLE G1R9T9_NOMLE PIM2 PIM2 BTK BTK SIK2 SIK2 ATM ATM ERBB4 ERBB4 AURKA AURKA MAPKAPK3 MAPKAPK3 STK17B STK17B MAP3K13 MAP3K13 TRPM7 TRPM7 EPHB3 EPHB3 PRKCG PRKCG MAP3K11 MAP3K11 DDR1 DDR1 SMG1 SMG1 TNIK TNIK DAPK1 DAPK1 GRK7 GRK7 MAP3K3 MAP3K3 CDK5 CDK5 EPHB1 EPHB1 MELK MELK NTRK2 NTRK2 TYRO3 TYRO3 LTK LTK CAMK2B CAMK2B STK39 STK39 EPHA1 EPHA1 IRAK3 IRAK3 CAD CAD EIF2AK3 EIF2AK3 MAP2K2 MAP2K2 DAPK3 DAPK3 PRKD2 PRKD2 NEK2 NEK2 FLT4 FLT4 MAP3K21 MAP3K21 LCK LCK CHEK2 CHEK2 G1QNP0_NOMLE G1QNP0_NOMLE MKNK2 MKNK2 MAPK3 MAPK3 MAP3K9 MAP3K9 NLK NLK PAK2 PAK2 ZAP70 ZAP70 STK11 STK11 LYN LYN EIF2AK1 EIF2AK1 TAF1 TAF1 RB1CC1 RB1CC1 MAPKAPK2 MAPKAPK2 VRK1 VRK1 EIF2S1 EIF2S1 FLT1 FLT1 SYK SYK INSR INSR FLT3 FLT3 STK10 STK10 TAOK3 TAOK3 MAPKAPK5 MAPKAPK5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GRK5G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (590 aa)
ERBB2Receptor protein-tyrosine kinase. (1247 aa)
MAP4K1Mitogen-activated protein kinase kinase kinase kinase 1; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (788 aa)
NEK6NIMA related kinase 6; Belongs to the protein kinase superfamily. (347 aa)
SRCTyrosine-protein kinase. (537 aa)
MARK2Non-specific serine/threonine protein kinase. (788 aa)
HTATIP2HIV-1 Tat interactive protein 2. (275 aa)
WNK2WNK lysine deficient protein kinase 2. (1977 aa)
CLK2CDC like kinase 2; Belongs to the protein kinase superfamily. (500 aa)
NTRK1Tyrosine-protein kinase receptor. (787 aa)
TAOK1TAO kinase 1. (1002 aa)
TRIM24Tripartite motif containing 24. (1049 aa)
MUSKMuscle associated receptor tyrosine kinase. (881 aa)
IGF1RTyrosine-protein kinase receptor. (1199 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1367 aa)
MEX3BMex-3 RNA binding family member B. (575 aa)
ENSNLEP00000042936Protein kinase domain-containing protein. (201 aa)
CAMK2AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (476 aa)
EIF2AK2Uncharacterized protein. (543 aa)
TAOK2TAO kinase 2. (1246 aa)
EPHA4EPH receptor A4. (967 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (591 aa)
ENSNLEP00000041863SMG1_N domain-containing protein. (611 aa)
THY1Ig-like domain-containing protein. (216 aa)
FYNTyrosine-protein kinase. (537 aa)
VRK2VRK serine/threonine kinase 2. (509 aa)
LMTK2Lemur tyrosine kinase 2. (1501 aa)
MARK3Non-specific serine/threonine protein kinase. (784 aa)
LOC100593010Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (459 aa)
MAKMale germ cell associated kinase. (648 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (533 aa)
ENSNLEP00000039390Protein kinase domain-containing protein. (673 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
PASKPAS domain containing serine/threonine kinase. (1323 aa)
AURKBUncharacterized protein. (123 aa)
STK26Serine/threonine kinase 26. (438 aa)
EEF2KEukaryotic elongation factor 2 kinase. (725 aa)
ENSNLEP00000036861Uncharacterized protein. (119 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1642 aa)
STK24Serine/threonine kinase 24. (443 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1023 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1099 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2578 aa)
FGRTyrosine-protein kinase. (476 aa)
CLK1CDC like kinase 1; Belongs to the protein kinase superfamily. (457 aa)
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1012 aa)
ENSNLEP00000031088Protein kinase domain-containing protein. (557 aa)
TRIM28Tripartite motif containing 28. (808 aa)
MKNK1MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (463 aa)
PTK6Tyrosine-protein kinase. (451 aa)
STK16Serine/threonine kinase 16. (319 aa)
EPHA8EPH receptor A8. (987 aa)
AAK1AP2 associated kinase 1. (946 aa)
STK4Serine/threonine kinase 4. (490 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
OXSR1Oxidative stress responsive kinase 1. (530 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
ENSNLEP00000026081Protein kinase domain-containing protein. (407 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2620 aa)
DAPK2Death associated protein kinase 2; Belongs to the protein kinase superfamily. (488 aa)
PRKACAProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (294 aa)
FGFR3Receptor protein-tyrosine kinase. (583 aa)
DYRK1ADual specificity tyrosine phosphorylation regulated kinase 1A. (758 aa)
PINK1Protein kinase domain-containing protein. (563 aa)
CDK12Cyclin dependent kinase 12. (1468 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2098 aa)
UHMK1U2AF homology motif kinase 1. (419 aa)
MOSMOS proto-oncogene, serine/threonine kinase; Belongs to the protein kinase superfamily. (346 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1304 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
ATG101Autophagy related 101. (218 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12. (747 aa)
STK33Serine/threonine kinase 33. (514 aa)
MINK1Misshapen like kinase 1. (1259 aa)
TXKTyrosine-protein kinase. (527 aa)
FGFR2Fibroblast growth factor receptor. (820 aa)
MYO3AMyosin IIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1609 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (871 aa)
WNK3WNK lysine deficient protein kinase 3. (1800 aa)
AATKApoptosis associated tyrosine kinase. (1244 aa)
CLK4CDC like kinase 4; Belongs to the protein kinase superfamily. (481 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (506 aa)
ALKUncharacterized protein. (1134 aa)
TSSK4Testis specific serine kinase 4. (337 aa)
SLKSTE20 like kinase. (1223 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (977 aa)
ULK3Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (403 aa)
CSKTyrosine-protein kinase. (274 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
CLK3CDC like kinase 3. (645 aa)
RIOK2RIO kinase 2. (553 aa)
DYRK1BProtein kinase domain-containing protein. (528 aa)
HIPK4Homeodomain interacting protein kinase 4. (564 aa)
MAP3K10Protein kinase domain-containing protein. (689 aa)
STK25Serine/threonine kinase 25. (416 aa)
ROS1Tyrosine-protein kinase receptor. (2347 aa)
INSRRTyrosine-protein kinase receptor. (1287 aa)
FGFR4Fibroblast growth factor receptor. (787 aa)
ABL1Tyrosine-protein kinase. (1006 aa)
TTKTTK protein kinase. (852 aa)
FGFR1Fibroblast growth factor receptor. (835 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (828 aa)
EPHB4EPH receptor B4. (890 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (402 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (949 aa)
SRMSTyrosine-protein kinase. (486 aa)
HCKTyrosine-protein kinase. (525 aa)
MYLK2Myosin light chain kinase 2. (596 aa)
CDKL5Cyclin dependent kinase like 5. (994 aa)
LOC100592336PH_3 domain-containing protein. (247 aa)
BMXTyrosine-protein kinase. (675 aa)
TNK1Tyrosine kinase non receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (661 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
PRKG2cGMP-dependent protein kinase. (762 aa)
ULK1Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1049 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (969 aa)
PEAK1Pseudopodium enriched atypical kinase 1. (1747 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1046 aa)
G1R9T9_NOMLEUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (784 aa)
PIM2Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (311 aa)
BTKTyrosine-protein kinase. (659 aa)
SIK2Salt inducible kinase 2. (926 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3055 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
AURKAAurora kinase A; Belongs to the protein kinase superfamily. (403 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (382 aa)
STK17BSerine/threonine kinase 17b; Belongs to the protein kinase superfamily. (371 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (966 aa)
TRPM7Transient receptor potential cation channel subfamily M member 7. (1866 aa)
EPHB3EPH receptor B3. (1053 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase. (847 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (913 aa)
SMG1Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2477 aa)
TNIKTRAF2 and NCK interacting kinase. (1360 aa)
DAPK1Death associated protein kinase 1. (1430 aa)
GRK7G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (553 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (628 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (320 aa)
EPHB1EPH receptor B1. (984 aa)
MELKNon-specific serine/threonine protein kinase. (651 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
TYRO3TYRO3 protein tyrosine kinase. (760 aa)
LTKLeukocyte receptor tyrosine kinase. (864 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (607 aa)
STK39Serine/threonine kinase 39. (507 aa)
EPHA1EPH receptor A1. (975 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (596 aa)
CADCarbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. (2200 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1120 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (383 aa)
DAPK3Death associated protein kinase 3. (407 aa)
PRKD2Uncharacterized protein. (716 aa)
NEK2NIMA related kinase 2. (445 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
MAP3K21Mitogen-activated protein kinase kinase kinase. (887 aa)
LCKLCK proto-oncogene, Src family tyrosine kinase. (448 aa)
CHEK2Checkpoint kinase 2. (487 aa)
G1QNP0_NOMLEProtein kinase domain-containing protein. (234 aa)
MKNK2Uncharacterized protein. (272 aa)
MAPK3Mitogen-activated protein kinase. (278 aa)
MAP3K9Mitogen-activated protein kinase kinase kinase 9. (1116 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
ZAP70Tyrosine-protein kinase. (704 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (423 aa)
LYNTyrosine-protein kinase. (512 aa)
EIF2AK1Eukaryotic translation initiation factor 2 alpha kinase 1. (614 aa)
TAF1TATA-box binding protein associated factor 1. (1767 aa)
RB1CC1RB1 inducible coiled-coil 1. (1594 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (370 aa)
VRK1VRK serine/threonine kinase 1; Belongs to the protein kinase superfamily. (396 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
SYKTyrosine-protein kinase. (532 aa)
INSRInsulin receptor. (1232 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
STK10Serine/threonine kinase 10. (916 aa)
TAOK3TAO kinase 3. (898 aa)
MAPKAPK5MAPK activated protein kinase 5. (471 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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