STRINGSTRING
ABCC8 ABCC8 OSM OSM JAGN1 JAGN1 GHRL GHRL CARTPT CARTPT CCN3 CCN3 STXBP5L STXBP5L GHSR GHSR ADIPOQ ADIPOQ CRY1 CRY1 KCNB1 KCNB1 FAM3D FAM3D SYTL4 SYTL4 RAB11FIP3 RAB11FIP3 REST REST INHA INHA RAB11FIP5 RAB11FIP5 IL11 IL11 NMB NMB TACR2 TACR2 PRKN PRKN RAB11FIP1 RAB11FIP1 LEP LEP SFRP1 SFRP1 CRHBP CRHBP FFAR4 FFAR4 NPVF NPVF SIRT4 SIRT4 TSPO TSPO CHGA CHGA CRY2 CRY2 ENSNLEP00000024736 ENSNLEP00000024736 HADH HADH ENSNLEP00000027584 ENSNLEP00000027584 MTNR1B MTNR1B SREBF1 SREBF1 CRH CRH PPP3CA PPP3CA ENSNLEP00000034652 ENSNLEP00000034652 LOC100605369 LOC100605369 IRS1 IRS1 ENSNLEP00000035372 ENSNLEP00000035372 ENSNLEP00000036074 ENSNLEP00000036074 KLF7 KLF7 ENSNLEP00000043688 ENSNLEP00000043688 IL1B IL1B KCNJ11 KCNJ11 PTPN11 PTPN11 KALRN KALRN EDN1 EDN1 FKBP1B FKBP1B ACVR1C ACVR1C FOXO1 FOXO1 PSMD9 PSMD9 MIDN MIDN VSNL1 VSNL1 PFKL PFKL NDUFAF2 NDUFAF2 FGF23 FGF23 INHBA INHBA UCN UCN LIF LIF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ABCC8ATP binding cassette subfamily C member 8. (1569 aa)
OSMOncostatin M. (252 aa)
JAGN1Jagunal homolog 1. (183 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
CARTPTCART prepropeptide. (116 aa)
CCN3Cellular communication network factor 3. (357 aa)
STXBP5LSyntaxin binding protein 5 like. (1177 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
CRY1Cryptochrome circadian regulator 1. (586 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
FAM3DFamily with sequence similarity 3 member D. (216 aa)
SYTL4Synaptotagmin like 4. (672 aa)
RAB11FIP3RAB11 family interacting protein 3. (651 aa)
RESTRE1 silencing transcription factor. (1097 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (366 aa)
RAB11FIP5RAB11 family interacting protein 5. (645 aa)
IL11Uncharacterized protein. (170 aa)
NMBUncharacterized protein. (121 aa)
TACR2Tachykinin receptor 2; Belongs to the G-protein coupled receptor 1 family. (393 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (437 aa)
RAB11FIP1RAB11 family interacting protein 1. (1221 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
FFAR4G_PROTEIN_RECEP_F1_2 domain-containing protein. (235 aa)
NPVFNeuropeptide VF precursor. (196 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
TSPOTranslocator protein. (169 aa)
CHGAChromogranin A. (460 aa)
CRY2Photolyase/cryptochrome alpha/beta domain-containing protein. (523 aa)
ENSNLEP00000024736Uncharacterized protein. (489 aa)
HADHHydroxyacyl-CoA dehydrogenase. (390 aa)
ENSNLEP00000027584SH2 domain-containing protein. (188 aa)
MTNR1BUncharacterized protein. (89 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1147 aa)
CRHCorticotropin releasing hormone. (196 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
ENSNLEP00000034652Uncharacterized protein. (265 aa)
LOC100605369Uncharacterized protein. (571 aa)
IRS1Insulin receptor substrate 1. (1242 aa)
ENSNLEP00000035372TGF_BETA_2 domain-containing protein. (392 aa)
ENSNLEP00000036074Uncharacterized protein. (393 aa)
KLF7Uncharacterized protein. (269 aa)
ENSNLEP00000043688Uncharacterized protein. (273 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
KCNJ11Potassium voltage-gated channel subfamily J member 11. (390 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
KALRNUncharacterized protein. (2931 aa)
EDN1Endothelin 1. (211 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (496 aa)
FOXO1Forkhead box O1. (652 aa)
PSMD9PDZ domain-containing protein. (222 aa)
MIDNUncharacterized protein. (463 aa)
VSNL1Visinin like 1. (191 aa)
PFKLPhosphofructokinase, liver type. (726 aa)
NDUFAF2NADH:ubiquinone oxidoreductase complex assembly factor 2. (168 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
INHBAInhibin subunit beta A. (426 aa)
UCNUrocortin. (124 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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