(46 nodes) Lung alveolus development network (Nomascus leucogenys)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	PTGES3	Prostaglandin E synthase 3. (164 aa)
	MMP12	Matrix metallopeptidase 12. (470 aa)
	ABCA12	ATP binding cassette subfamily A member 12. (2550 aa)
	IGFBP5	Insulin like growth factor binding protein 5. (272 aa)
	PDGFA	Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
	ERRFI1	ERBB receptor feedback inhibitor 1. (462 aa)
	ASXL1	ASXL transcriptional regulator 1. (1536 aa)
	SFTPD	Surfactant protein D. (375 aa)
	MAN2A1	Alpha-mannosidase. (1128 aa)
	STK40	Serine/threonine kinase 40. (440 aa)
	FOXF1	Uncharacterized protein. (361 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	EDN2	Endothelin 2. (177 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	GATA6	Uncharacterized protein. (452 aa)
	LTBP3	Uncharacterized protein. (1148 aa)
	SMPD3	Sphingomyelin phosphodiesterase 3. (655 aa)
	MAN1A2	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (634 aa)
	NKX2-1	NK2 homeobox 1. (394 aa)
	LIF	LIF interleukin 6 family cytokine. (202 aa)
	FLT4	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
	ATP7A	ATPase copper transporting alpha. (1460 aa)
	PGR	Uncharacterized protein. (339 aa)
	SLC7A11	Solute carrier family 7 member 11. (500 aa)
	HS6ST1	Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (411 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	PKDCC	Protein kinase domain containing, cytoplasmic. (493 aa)
	FGFR2	Fibroblast growth factor receptor. (820 aa)
	RC3H2	Ring finger and CCCH-type domains 2. (1180 aa)
	TMEM38B	Transmembrane protein 38B. (291 aa)
	ATXN1L	Ataxin 1 like. (689 aa)
	PHF14	PHD finger protein 14. (946 aa)
	ITGB6	Integrin beta; Belongs to the integrin beta chain family. (788 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	STRA6	Stimulated by retinoic acid 6. (636 aa)
	ADA	Adenosine deaminase. (405 aa)
	TCF21	Transcription factor 21. (179 aa)
	ENSNLEP00000033486	Uncharacterized protein. (126 aa)
	NKIRAS1	NFKB inhibitor interacting Ras like 1. (192 aa)
	FOXA1	Uncharacterized protein. (346 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
	NKIRAS2	NFKB inhibitor interacting Ras like 2. (231 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1367 aa)
	HOPX	Uncharacterized protein. (91 aa)
	MYOCD	Myocardin. (986 aa)

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	BMPR2	ENSNLEP00000015368	ENSNLEP00000041806	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.997
BMP4	FGF10	ENSNLEP00000015368	ENSNLEP00000029066	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.680
BMP4	FGFR2	ENSNLEP00000015368	ENSNLEP00000020533	Bone morphogenetic protein 4.	Fibroblast growth factor receptor.	0.511
BMP4	FOXF1	ENSNLEP00000015368	ENSNLEP00000013913	Bone morphogenetic protein 4.	Uncharacterized protein.	0.748
BMP4	GATA6	ENSNLEP00000015368	ENSNLEP00000008281	Bone morphogenetic protein 4.	Uncharacterized protein.	0.545
BMP4	KDR	ENSNLEP00000015368	ENSNLEP00000044105	Bone morphogenetic protein 4.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.484
BMP4	LIF	ENSNLEP00000015368	ENSNLEP00000004251	Bone morphogenetic protein 4.	LIF interleukin 6 family cytokine.	0.507
BMP4	PDGFA	ENSNLEP00000015368	ENSNLEP00000010045	Bone morphogenetic protein 4.	Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family.	0.480
BMPR2	BMP4	ENSNLEP00000041806	ENSNLEP00000015368	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4.	0.997
BMPR2	KDR	ENSNLEP00000041806	ENSNLEP00000044105	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.506
BMPR2	TGFB1	ENSNLEP00000041806	ENSNLEP00000016659	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.616
BMPR2	TGFB3	ENSNLEP00000041806	ENSNLEP00000020116	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.542
ENSNLEP00000033486	FOXA1	ENSNLEP00000033486	ENSNLEP00000040724	Uncharacterized protein.	Uncharacterized protein.	0.771
ENSNLEP00000033486	GATA6	ENSNLEP00000033486	ENSNLEP00000008281	Uncharacterized protein.	Uncharacterized protein.	0.731
FGF10	BMP4	ENSNLEP00000029066	ENSNLEP00000015368	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4.	0.680
FGF10	FGFR2	ENSNLEP00000029066	ENSNLEP00000020533	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.999
FGF10	FLT4	ENSNLEP00000029066	ENSNLEP00000003032	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.873
FGF10	KDR	ENSNLEP00000029066	ENSNLEP00000044105	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.891
FGF10	LIF	ENSNLEP00000029066	ENSNLEP00000004251	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	LIF interleukin 6 family cytokine.	0.488
FGF10	STRA6	ENSNLEP00000029066	ENSNLEP00000029878	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Stimulated by retinoic acid 6.	0.417

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