(24 nodes) Mesodermal cell differentiation network (Nomascus leucogenys)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FOXF1	Uncharacterized protein. (361 aa)
	ITGA3	Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1050 aa)
	EYA2	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (512 aa)
	SFRP2	Secreted frizzled related protein 2. (280 aa)
	SMAD1	Mothers against decapentaplegic homolog. (465 aa)
	G1QSA7_NOMLE	Uncharacterized protein. (109 aa)
	TBX6	T-box transcription factor 6. (364 aa)
	INHBA	Inhibin subunit beta A. (426 aa)
	ITGB4	Integrin beta. (1746 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
	ETV2	ETS variant 2. (337 aa)
	ITGA2	Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1181 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (806 aa)
	KLF4	Uncharacterized protein. (145 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	KDM6A	Lysine demethylase 6A. (1450 aa)
	TAF10	Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
	FGFR2	Fibroblast growth factor receptor. (820 aa)
	SIX2	SIX homeobox 2. (293 aa)
	NODAL	Nodal growth differentiation factor. (347 aa)
	HOXA11	Homeobox A11. (313 aa)
	PAX2	Paired domain-containing protein. (385 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	ITGA8	Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1048 aa)

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	EYA1	ENSNLEP00000015368	ENSNLEP00000044517	Bone morphogenetic protein 4.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.471
BMP4	FGFR2	ENSNLEP00000015368	ENSNLEP00000020533	Bone morphogenetic protein 4.	Fibroblast growth factor receptor.	0.511
BMP4	FOXF1	ENSNLEP00000015368	ENSNLEP00000013913	Bone morphogenetic protein 4.	Uncharacterized protein.	0.748
BMP4	KLF4	ENSNLEP00000015368	ENSNLEP00000029564	Bone morphogenetic protein 4.	Uncharacterized protein.	0.462
BMP4	PAX2	ENSNLEP00000015368	ENSNLEP00000017976	Bone morphogenetic protein 4.	Paired domain-containing protein.	0.448
BMP4	SMAD1	ENSNLEP00000015368	ENSNLEP00000006702	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.619
BMP4	WNT3A	ENSNLEP00000015368	ENSNLEP00000026289	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.699
EYA1	BMP4	ENSNLEP00000044517	ENSNLEP00000015368	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Bone morphogenetic protein 4.	0.471
EYA1	EYA2	ENSNLEP00000044517	ENSNLEP00000008408	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.435
EYA1	HOXA11	ENSNLEP00000044517	ENSNLEP00000018229	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Homeobox A11.	0.482
EYA1	PAX2	ENSNLEP00000044517	ENSNLEP00000017976	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Paired domain-containing protein.	0.671
EYA1	SIX2	ENSNLEP00000044517	ENSNLEP00000020487	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	SIX homeobox 2.	0.831
EYA2	EYA1	ENSNLEP00000008408	ENSNLEP00000044517	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.435
EYA2	SIX2	ENSNLEP00000008408	ENSNLEP00000020487	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	SIX homeobox 2.	0.798
FGFR2	BMP4	ENSNLEP00000020533	ENSNLEP00000015368	Fibroblast growth factor receptor.	Bone morphogenetic protein 4.	0.511
FOXF1	BMP4	ENSNLEP00000013913	ENSNLEP00000015368	Uncharacterized protein.	Bone morphogenetic protein 4.	0.748
HOXA11	EYA1	ENSNLEP00000018229	ENSNLEP00000044517	Homeobox A11.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.482
HOXA11	PAX2	ENSNLEP00000018229	ENSNLEP00000017976	Homeobox A11.	Paired domain-containing protein.	0.583
INHBA	NODAL	ENSNLEP00000003813	ENSNLEP00000019553	Inhibin subunit beta A.	Nodal growth differentiation factor.	0.901
INHBA	SMAD1	ENSNLEP00000003813	ENSNLEP00000006702	Inhibin subunit beta A.	Mothers against decapentaplegic homolog.	0.421

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