(18 nodes) Paraxial mesoderm development network (Nomascus leucogenys)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HNF1A	Uncharacterized protein. (562 aa)
	TCF15	Transcription factor 15. (197 aa)
	EPB41L5	Erythrocyte membrane protein band 4.1 like 5. (732 aa)
	ZIC3	Uncharacterized protein. (360 aa)
	POGLUT1	Protein O-glucosyltransferase 1. (392 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	DLL3	Delta like canonical Notch ligand 3. (619 aa)
	LEF1	Lymphoid enhancer binding factor 1. (386 aa)
	ENSNLEP00000032543	Uncharacterized protein. (168 aa)
	YAP1	Uncharacterized protein. (418 aa)
	ENSNLEP00000028086	Fork-head domain-containing protein. (459 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	BMPR1A	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	NUP133	Nucleoporin 133. (1156 aa)
	EXOC4	Exocyst complex component 4. (974 aa)

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMPR1A	SMAD2	ENSNLEP00000025455	ENSNLEP00000023604	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.964
BMPR1A	SMAD3	ENSNLEP00000025455	ENSNLEP00000041430	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.958
ENSNLEP00000028086	TCF15	ENSNLEP00000028086	ENSNLEP00000011465	Fork-head domain-containing protein.	Transcription factor 15.	0.462
ENSNLEP00000032543	SMAD2	ENSNLEP00000032543	ENSNLEP00000023604	Uncharacterized protein.	Mothers against decapentaplegic homolog.	0.688
ENSNLEP00000032543	SMAD3	ENSNLEP00000032543	ENSNLEP00000041430	Uncharacterized protein.	Mothers against decapentaplegic homolog.	0.577
LEF1	SMAD2	ENSNLEP00000035051	ENSNLEP00000023604	Lymphoid enhancer binding factor 1.	Mothers against decapentaplegic homolog.	0.821
LEF1	SMAD3	ENSNLEP00000035051	ENSNLEP00000041430	Lymphoid enhancer binding factor 1.	Mothers against decapentaplegic homolog.	0.821
LEF1	WNT11	ENSNLEP00000035051	ENSNLEP00000020458	Lymphoid enhancer binding factor 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.457
LEF1	WNT3A	ENSNLEP00000035051	ENSNLEP00000026289	Lymphoid enhancer binding factor 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.739
LEF1	WNT5A	ENSNLEP00000035051	ENSNLEP00000008828	Lymphoid enhancer binding factor 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.536
LEF1	YAP1	ENSNLEP00000035051	ENSNLEP00000031727	Lymphoid enhancer binding factor 1.	Uncharacterized protein.	0.838
SMAD2	BMPR1A	ENSNLEP00000023604	ENSNLEP00000025455	Mothers against decapentaplegic homolog.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.964
SMAD2	ENSNLEP00000032543	ENSNLEP00000023604	ENSNLEP00000032543	Mothers against decapentaplegic homolog.	Uncharacterized protein.	0.688
SMAD2	LEF1	ENSNLEP00000023604	ENSNLEP00000035051	Mothers against decapentaplegic homolog.	Lymphoid enhancer binding factor 1.	0.821
SMAD2	SMAD3	ENSNLEP00000023604	ENSNLEP00000041430	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.999
SMAD2	YAP1	ENSNLEP00000023604	ENSNLEP00000031727	Mothers against decapentaplegic homolog.	Uncharacterized protein.	0.967
SMAD2	ZIC3	ENSNLEP00000023604	ENSNLEP00000003643	Mothers against decapentaplegic homolog.	Uncharacterized protein.	0.401
SMAD3	BMPR1A	ENSNLEP00000041430	ENSNLEP00000025455	Mothers against decapentaplegic homolog.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.958
SMAD3	ENSNLEP00000032543	ENSNLEP00000041430	ENSNLEP00000032543	Mothers against decapentaplegic homolog.	Uncharacterized protein.	0.577
SMAD3	LEF1	ENSNLEP00000041430	ENSNLEP00000035051	Mothers against decapentaplegic homolog.	Lymphoid enhancer binding factor 1.	0.821

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