STRINGSTRING
NKX2-2 NKX2-2 OXTR OXTR HIF1A HIF1A SRC SRC COBL COBL YIPF6 YIPF6 TNF TNF FZD5 FZD5 HMGCS2 HMGCS2 MYOCD MYOCD CXCL8 CXCL8 ENSNLEP00000045603 ENSNLEP00000045603 NKX2-3 NKX2-3 HOXD13 HOXD13 ENSNLEP00000043042 ENSNLEP00000043042 FOXE1 FOXE1 ENSNLEP00000042382 ENSNLEP00000042382 ENSNLEP00000041886 ENSNLEP00000041886 SMAD3 SMAD3 CLMP CLMP ENSNLEP00000041025 ENSNLEP00000041025 TIGAR TIGAR PDGFC PDGFC SAV1 SAV1 ENSNLEP00000037553 ENSNLEP00000037553 PKD1 PKD1 BCL2 BCL2 EGFR EGFR ENSNLEP00000034094 ENSNLEP00000034094 CCKBR CCKBR HOXA13 HOXA13 TP63 TP63 ENSNLEP00000032543 ENSNLEP00000032543 TCF21 TCF21 YAP1 YAP1 ADA ADA PTK6 PTK6 CLDN18 CLDN18 STRA6 STRA6 FGF10 FGF10 MIXL1 MIXL1 ENSNLEP00000028114 ENSNLEP00000028114 CPS1 CPS1 ASCL1 ASCL1 SOX9 SOX9 ENSNLEP00000027205 ENSNLEP00000027205 ENSNLEP00000026885 ENSNLEP00000026885 ENSNLEP00000025620 ENSNLEP00000025620 SOX10 SOX10 MEGF8 MEGF8 NIPBL NIPBL SMAD2 SMAD2 LGR4 LGR4 DCHS1 DCHS1 GLI1 GLI1 FGFR2 FGFR2 SIX2 SIX2 WNT11 WNT11 PKDCC PKDCC TGFB3 TGFB3 AGR2 AGR2 EDNRB EDNRB NKX3-2 NKX3-2 NODAL NODAL C1GALT1 C1GALT1 NKX2-6 NKX2-6 GATA5 GATA5 RET RET CCDC40 CCDC40 GATA4 GATA4 AHI1 AHI1 CHD8 CHD8 TGFB2 TGFB2 HLX HLX TGFB1 TGFB1 DACT1 DACT1 FGF9 FGF9 PRDM1 PRDM1 ID2 ID2 BMP4 BMP4 SMO SMO SFRP1 SFRP1 ASS1 ASS1 FOXF1 FOXF1 ALDH1A2 ALDH1A2 G1RJG4_NOMLE G1RJG4_NOMLE FOXF2 FOXF2 CBFA2T2 CBFA2T2 BBS7 BBS7 IHH IHH SPDEF SPDEF KIT KIT NOTCH1 NOTCH1 WNT5A WNT5A TYMS TYMS VPS52 VPS52 GATA6 GATA6 COL3A1 COL3A1 EPHB3 EPHB3 SFRP2 SFRP2 CCDC39 CCDC39 CTNNB1 CTNNB1 PYY PYY ACVR2B ACVR2B CCDC103 CCDC103 EXT1 EXT1 TGFBR2 TGFBR2 IFT172 IFT172 RARB RARB RB1 RB1 GLI3 GLI3 ZIC3 ZIC3 IL6ST IL6ST PCSK5 PCSK5 OTC OTC SOX17 SOX17 SALL1 SALL1 GLI2 GLI2 EPB41L5 EPB41L5 TBX2 TBX2 CDX2 CDX2 PDX1 PDX1 CRKL CRKL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NKX2-2NK2 homeobox 2. (273 aa)
OXTROxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (389 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
SRCTyrosine-protein kinase. (537 aa)
COBLCordon-bleu WH2 repeat protein. (1347 aa)
YIPF6Protein YIPF. (236 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
MYOCDMyocardin. (986 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
ENSNLEP00000045603Uncharacterized protein. (252 aa)
NKX2-3NK2 homeobox 3. (363 aa)
HOXD13Homeobox D13. (306 aa)
ENSNLEP00000043042Uncharacterized protein. (214 aa)
FOXE1Fork-head domain-containing protein. (344 aa)
ENSNLEP00000042382Uncharacterized protein. (425 aa)
ENSNLEP00000041886Ion_trans domain-containing protein; Belongs to the potassium channel family. (359 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
CLMPCXADR like membrane protein. (375 aa)
ENSNLEP00000041025Uncharacterized protein. (381 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
ENSNLEP00000037553Uncharacterized protein. (100 aa)
PKD1Uncharacterized protein. (270 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
ENSNLEP00000034094Uncharacterized protein. (313 aa)
CCKBRG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (514 aa)
HOXA13Homeobox domain-containing protein. (227 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
ENSNLEP00000032543Uncharacterized protein. (168 aa)
TCF21Transcription factor 21. (179 aa)
YAP1Uncharacterized protein. (418 aa)
ADAAdenosine deaminase. (405 aa)
PTK6Tyrosine-protein kinase. (451 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
STRA6Stimulated by retinoic acid 6. (636 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
MIXL1Mix paired-like homeobox. (232 aa)
ENSNLEP00000028114Uncharacterized protein. (405 aa)
CPS1Carbamoyl-phosphate synthase 1. (1506 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (235 aa)
SOX9SRY-box transcription factor 9. (510 aa)
ENSNLEP00000027205Uncharacterized protein. (353 aa)
ENSNLEP00000026885Uncharacterized protein. (333 aa)
ENSNLEP00000025620Uncharacterized protein. (154 aa)
SOX10HMG box domain-containing protein. (236 aa)
MEGF8Multiple EGF like domains 8. (2574 aa)
NIPBLNipped-B protein. (2803 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (929 aa)
DCHS1Dachsous cadherin-related 1. (3297 aa)
GLI1GLI family zinc finger 1. (1106 aa)
FGFR2Fibroblast growth factor receptor. (820 aa)
SIX2SIX homeobox 2. (293 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (493 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
AGR2Anterior gradient 2, protein disulphide isomerase family member. (189 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (532 aa)
NKX3-2NK3 homeobox 2. (341 aa)
NODALNodal growth differentiation factor. (347 aa)
C1GALT1Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal- beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins; Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily. (363 aa)
NKX2-6NK2 homeobox 6. (301 aa)
GATA5GATA binding protein 5. (363 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1114 aa)
CCDC40Coiled-coil domain containing 40. (1137 aa)
GATA4GATA binding protein 4. (443 aa)
AHI1Abelson helper integration site 1. (1195 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2579 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
HLXH2.0 like homeobox. (441 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (837 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PRDM1PR/SET domain 1. (825 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (683 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
ASS1Uncharacterized protein. (412 aa)
FOXF1Uncharacterized protein. (361 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
G1RJG4_NOMLEDynein assembly factor 1, axonemal. (655 aa)
FOXF2Uncharacterized protein. (265 aa)
CBFA2T2CBFA2/RUNX1 partner transcriptional co-repressor 2. (614 aa)
BBS7Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa)
IHHIndian hedgehog signaling molecule. (389 aa)
SPDEFSAM pointed domain containing ETS transcription factor. (335 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (969 aa)
NOTCH1Notch receptor 1. (2451 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
TYMSThymidylat_synt domain-containing protein. (173 aa)
VPS52VPS52 subunit of GARP complex. (723 aa)
GATA6Uncharacterized protein. (452 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
EPHB3EPH receptor B3. (1053 aa)
SFRP2Secreted frizzled related protein 2. (280 aa)
CCDC39Coiled-coil domain containing 39. (942 aa)
CTNNB1Catenin beta 1. (781 aa)
PYYPeptide YY. (97 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
CCDC103Coiled-coil domain containing 103. (242 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (745 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
IFT172Intraflagellar transport 172. (1703 aa)
RARBRetinoic acid receptor beta. (448 aa)
RB1RB transcriptional corepressor 1. (919 aa)
GLI3GLI family zinc finger 3. (1502 aa)
ZIC3Uncharacterized protein. (360 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1860 aa)
OTCOrnithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (354 aa)
SOX17SRY-box transcription factor 17. (410 aa)
SALL1Spalt like transcription factor 1. (1219 aa)
GLI2GLI family zinc finger 2. (1589 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (732 aa)
TBX2T-box transcription factor 2. (647 aa)
CDX2Caudal type homeobox 2. (309 aa)
PDX1Pancreatic and duodenal homeobox 1. (283 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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