STRINGSTRING
PTGS2 PTGS2 HTR1B HTR1B BMPR1A BMPR1A ENSNLEP00000025813 ENSNLEP00000025813 DNMT1 DNMT1 AKT1 AKT1 ENSNLEP00000030944 ENSNLEP00000030944 LDLRAP1 LDLRAP1 ITGB3 ITGB3 STAT1 STAT1 CCN4 CCN4 FOXP1 FOXP1 ENSNLEP00000035153 ENSNLEP00000035153 IL6R IL6R ENSNLEP00000036074 ENSNLEP00000036074 FRS2 FRS2 MEF2D MEF2D ENSNLEP00000037203 ENSNLEP00000037203 IL18 IL18 S1PR1 S1PR1 ENSNLEP00000039390 ENSNLEP00000039390 NF1 NF1 NOX1 NOX1 P2RY6 P2RY6 ITGA2 ITGA2 ENSNLEP00000042917 ENSNLEP00000042917 XBP1 XBP1 THBS1 THBS1 IGF1R IGF1R IGF1 IGF1 HMOX1 HMOX1 ENSNLEP00000046375 ENSNLEP00000046375 IL6 IL6 TNF TNF MAP3K5 MAP3K5 AIF1 AIF1 SRC SRC NOTCH3 NOTCH3 LOC100595279 LOC100595279 IRAK4 IRAK4 ZNF143 ZNF143 SERPINF2 SERPINF2 NR4A3 NR4A3 FGFR2 FGFR2 PDGFB PDGFB ERN1 ERN1 JUN JUN DDR2 DDR2 CCL5 CCL5 MNAT1 MNAT1 TGFB1 TGFB1 FGF9 FGF9 ID2 ID2 BMP4 BMP4 TERT TERT PDGFRB PDGFRB MFN2 MFN2 PTAFR PTAFR ALOX12 ALOX12 HBEGF HBEGF EREG EREG IGFBP5 IGFBP5 GNAI2 GNAI2 MMP9 MMP9 HPGD HPGD CALCRL CALCRL PIK3CA PIK3CA SMPD3 SMPD3 TGFBR2 TGFBR2 PHB PHB CX3CL1 CX3CL1 ADAMTS1 ADAMTS1 FOXJ2 FOXJ2 MMP2 MMP2 ELANE ELANE EDN1 EDN1 RPS6KB1 RPS6KB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
HTR1B5-hydroxytryptamine receptor 1B. (390 aa)
BMPR1ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
ENSNLEP00000025813Prohibitin. (188 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1646 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
ENSNLEP00000030944Prohibitin. (220 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (299 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (806 aa)
STAT1Signal transducer and activator of transcription. (780 aa)
CCN4Cellular communication network factor 4. (318 aa)
FOXP1Forkhead box P1. (693 aa)
ENSNLEP00000035153Prohibitin. (261 aa)
IL6RInterleukin 6 receptor. (420 aa)
ENSNLEP00000036074Uncharacterized protein. (393 aa)
FRS2Fibroblast growth factor receptor substrate 2. (522 aa)
MEF2DMADS-box domain-containing protein. (139 aa)
ENSNLEP00000037203Prohibitin. (260 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
ENSNLEP00000039390Protein kinase domain-containing protein. (673 aa)
NF1Neurofibromin 1. (2839 aa)
NOX1NADPH oxidase 1. (564 aa)
P2RY6Pyrimidinergic receptor P2Y6. (328 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1181 aa)
ENSNLEP00000042917Prohibitin. (131 aa)
XBP1BZIP domain-containing protein. (376 aa)
THBS1Thrombospondin 1. (1173 aa)
IGF1RTyrosine-protein kinase receptor. (1199 aa)
IGF1IlGF domain-containing protein. (196 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
ENSNLEP00000046375Prohibitin. (169 aa)
IL6Uncharacterized protein. (258 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1347 aa)
AIF1Allograft inflammatory factor 1. (161 aa)
SRCTyrosine-protein kinase. (537 aa)
NOTCH3Notch receptor 3. (2149 aa)
LOC100595279Uncharacterized protein. (212 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
ZNF143Zinc finger protein 143. (536 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (468 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (636 aa)
FGFR2Fibroblast growth factor receptor. (820 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (233 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (977 aa)
JUNBZIP domain-containing protein; Belongs to the bZIP family. (305 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
CCL5C-C motif chemokine. (91 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (983 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (722 aa)
PTAFRPlatelet activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (342 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (639 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
EREGEpiregulin. (169 aa)
IGFBP5Insulin like growth factor binding protein 5. (272 aa)
GNAI2G protein subunit alpha i2. (355 aa)
MMP9Matrix metallopeptidase 9. (692 aa)
HPGD15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
CALCRLCalcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (461 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
PHBProhibitin. (272 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (397 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (967 aa)
FOXJ2Forkhead box J2. (573 aa)
MMP2Matrix metallopeptidase 2. (647 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (239 aa)
EDN1Endothelin 1. (211 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (513 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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