STRINGSTRING
MAML1 MAML1 TBX5 TBX5 TBX2 TBX2 NKX2-5 NKX2-5 MYL2 MYL2 ZFPM1 ZFPM1 MED1 MED1 ACVR1 ACVR1 JARID2 JARID2 TBX20 TBX20 MYL3 MYL3 SMAD7 SMAD7 ENSNLEP00000048056 ENSNLEP00000048056 WT1 WT1 MYOCD MYOCD LMNA LMNA HOPX HOPX TENM4 TENM4 SCN5A SCN5A NRG1 NRG1 TNNI1 TNNI1 MYH11 MYH11 PLEC PLEC ENSNLEP00000044511 ENSNLEP00000044511 ENSNLEP00000044243 ENSNLEP00000044243 RYR2 RYR2 ADRA1A ADRA1A NOG NOG TBX3 TBX3 ARID2 ARID2 HNRNPU HNRNPU TGFBR1 TGFBR1 FHL2 FHL2 CDC42 CDC42 ALPK3 ALPK3 S1PR1 S1PR1 TCAP TCAP ENSNLEP00000038427 ENSNLEP00000038427 SAV1 SAV1 GJB6 GJB6 NEB NEB WNT8A WNT8A FHOD3 FHOD3 EGLN1 EGLN1 ENSNLEP00000036074 ENSNLEP00000036074 HEY1 HEY1 CHD7 CHD7 MEF2C MEF2C MTOR MTOR ENSNLEP00000033428 ENSNLEP00000033428 TPM1 TPM1 MYL7 MYL7 GJC1 GJC1 GJA5 GJA5 IRX3 IRX3 LOC100583914 LOC100583914 CACNA1G CACNA1G LOC100582441 LOC100582441 SLC8A1 SLC8A1 PDLIM5 PDLIM5 IFT20 IFT20 PLN PLN ENSNLEP00000028086 ENSNLEP00000028086 TNNT2 TNNT2 SGCD SGCD MAP2K4 MAP2K4 WNT3A WNT3A BMPR1A BMPR1A MAPK11 MAPK11 ENG ENG MEF2A MEF2A HEG1 HEG1 LRRC10B LRRC10B CSRP3 CSRP3 ASB2 ASB2 FGFR2 FGFR2 PKP2 PKP2 HAND1 HAND1 NRAP NRAP NKX2-6 NKX2-6 GATA5 GATA5 CBY1 CBY1 MYH7 MYH7 MYH6 MYH6 GATA4 GATA4 MYBPC3 MYBPC3 PROX1 PROX1 HCN4 HCN4 TAZ TAZ TGFB2 TGFB2 BVES BVES BMP2 BMP2 HEY2 HEY2 TGFB1 TGFB1 SGCG SGCG FGF9 FGF9 ATG5 ATG5 CALR CALR TSC1 TSC1 TBX18 TBX18 LOC100583116 LOC100583116 NEBL NEBL BMP4 BMP4 ANKRD1 ANKRD1 PTEN PTEN ZMPSTE24 ZMPSTE24 COL11A1 COL11A1 ADAMTS9 ADAMTS9 SMAD4 SMAD4 MESP1 MESP1 DSP DSP WNT2 WNT2 MSC MSC SORBS2 SORBS2 AKAP13 AKAP13 ALDH1A2 ALDH1A2 TNNI3 TNNI3 FOXH1 FOXH1 ISL1 ISL1 GREM1 GREM1 TGFBR3 TGFBR3 PDGFRB PDGFRB BMP10 BMP10 NPPB NPPB MYLK2 MYLK2 ACADM ACADM OBSL1 OBSL1 SLC9A1 SLC9A1 NOTCH1 NOTCH1 MYL10 MYL10 ALPK2 ALPK2 NPRL3 NPRL3 VWA5B1 VWA5B1 MYO18B MYO18B VWA5A VWA5A WNT5A WNT5A TNNC1 TNNC1 BMP7 BMP7 GATA6 GATA6 DSG2 DSG2 VWA5B2 VWA5B2 G1R2U7_NOMLE G1R2U7_NOMLE EDNRA EDNRA SMAD1 SMAD1 PRMT1 PRMT1 DIPK2A DIPK2A LRP2 LRP2 PTCD2 PTCD2 SRF SRF ZFPM2 ZFPM2 CAV3 CAV3 RARB RARB ACTN2 ACTN2 NDRG4 NDRG4 DLL4 DLL4 BMP5 BMP5 SIRT6 SIRT6 ZIC3 ZIC3 SGCZ SGCZ CXADR CXADR PPP1R13L PPP1R13L RARA RARA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAML1Mastermind like transcriptional coactivator 1. (1016 aa)
TBX5T-box transcription factor 5. (508 aa)
TBX2T-box transcription factor 2. (647 aa)
NKX2-5NK2 homeobox 5. (317 aa)
MYL2Myosin light chain 2. (166 aa)
ZFPM1Zinc finger protein, FOG family member 1. (897 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1558 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1225 aa)
TBX20T-box transcription factor 20. (447 aa)
MYL3EF-hand domain-containing protein. (161 aa)
SMAD7Mothers against decapentaplegic homolog. (376 aa)
ENSNLEP00000048056Uncharacterized protein. (115 aa)
WT1WT1 transcription factor. (302 aa)
MYOCDMyocardin. (986 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (664 aa)
HOPXUncharacterized protein. (91 aa)
TENM4Teneurin transmembrane protein 4. (2768 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1925 aa)
NRG1Neuregulin 1. (713 aa)
TNNI1Troponin I1, slow skeletal type. (187 aa)
MYH11Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1892 aa)
PLECPlectin. (4280 aa)
ENSNLEP00000044511POU domain protein. (242 aa)
ENSNLEP00000044243IGv domain-containing protein. (199 aa)
RYR2Ryanodine receptor 2. (4825 aa)
ADRA1AAdrenoceptor alpha 1A. (470 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
TBX3T-box transcription factor 3. (743 aa)
ARID2AT-rich interaction domain 2. (1782 aa)
HNRNPUB30.2/SPRY domain-containing protein. (725 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
FHL2Uncharacterized protein. (361 aa)
CDC42Cell division cycle 42. (191 aa)
ALPK3Uncharacterized protein. (1636 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
TCAPTitin-cap. (167 aa)
ENSNLEP00000038427Uncharacterized protein. (305 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
GJB6Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (261 aa)
NEBNebulin. (8034 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
FHOD3Formin homology 2 domain containing 3. (1567 aa)
EGLN1Egl-9 family hypoxia inducible factor 1. (416 aa)
ENSNLEP00000036074Uncharacterized protein. (393 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (308 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2997 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2578 aa)
ENSNLEP00000033428Protein kinase domain-containing protein. (369 aa)
TPM1Uncharacterized protein; Belongs to the tropomyosin family. (326 aa)
MYL7Myosin light chain 7. (197 aa)
GJC1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (396 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
IRX3Iroquois homeobox 3. (476 aa)
LOC100583914Uncharacterized protein. (322 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2317 aa)
LOC100582441Uncharacterized protein. (826 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (972 aa)
PDLIM5PDZ and LIM domain 5. (619 aa)
IFT20Uncharacterized protein. (148 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
ENSNLEP00000028086Fork-head domain-containing protein. (459 aa)
TNNT2Uncharacterized protein. (339 aa)
SGCDSarcoglycan delta. (290 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
BMPR1ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
MAPK11Mitogen-activated protein kinase. (350 aa)
ENGEndoglin. (658 aa)
MEF2AMyocyte enhancer factor 2A. (509 aa)
HEG1Heart development protein with EGF like domains 1. (1194 aa)
LRRC10BLeucine rich repeat containing 10B. (292 aa)
CSRP3Cysteine and glycine rich protein 3. (194 aa)
ASB2Ankyrin repeat and SOCS box containing 2. (635 aa)
FGFR2Fibroblast growth factor receptor. (820 aa)
PKP2Uncharacterized protein. (841 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
NRAPNebulin related anchoring protein. (1730 aa)
NKX2-6NK2 homeobox 6. (301 aa)
GATA5GATA binding protein 5. (363 aa)
CBY1Chibby family member 1, beta catenin antagonist. (161 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1899 aa)
MYH6Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1823 aa)
GATA4GATA binding protein 4. (443 aa)
MYBPC3Uncharacterized protein. (789 aa)
PROX1Prospero homeobox 1. (737 aa)
HCN4Cyclic nucleotide-binding domain-containing protein. (754 aa)
TAZTafazzin family protein; Some isoforms may be involved in cardiolipin metabolism. (239 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
BVESBlood vessel epicardial substance. (360 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SGCGSarcoglycan gamma. (291 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
CALRCalreticulin. (417 aa)
TSC1TSC complex subunit 1. (1164 aa)
TBX18T-box transcription factor 18. (607 aa)
LOC100583116Uncharacterized protein. (80 aa)
NEBLNebulette. (1014 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
ANKRD1Ankyrin repeat domain 1. (286 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (480 aa)
COL11A1Collagen type XI alpha 1 chain. (1800 aa)
ADAMTS9ADAM metallopeptidase with thrombospondin type 1 motif 9. (1935 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
MESP1Uncharacterized protein. (170 aa)
DSPDesmoplakin. (2817 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
MSCBHLH domain-containing protein. (297 aa)
SORBS2Sorbin and SH3 domain containing 2. (1201 aa)
AKAP13A-kinase anchoring protein 13. (2761 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
TNNI3Troponin I3, cardiac type. (210 aa)
FOXH1Forkhead box H1. (366 aa)
ISL1ISL LIM homeobox 1. (349 aa)
GREM1CTCK domain-containing protein. (143 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
NPPBNatriuretic peptide B. (134 aa)
MYLK2Myosin light chain kinase 2. (596 aa)
ACADMAcyl-CoA dehydrogenase medium chain. (454 aa)
OBSL1Uncharacterized protein. (1552 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (809 aa)
NOTCH1Notch receptor 1. (2451 aa)
MYL10Myosin light chain 10. (226 aa)
ALPK2Alpha kinase 2. (2085 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (505 aa)
VWA5B1Von Willebrand factor A domain containing 5B1. (1068 aa)
MYO18BMyosin XVIIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2287 aa)
VWA5AVon Willebrand factor A domain containing 5A. (786 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (161 aa)
BMP7Bone morphogenetic protein 7. (430 aa)
GATA6Uncharacterized protein. (452 aa)
DSG2Desmoglein 2. (1098 aa)
VWA5B2Von Willebrand factor A domain containing 5B2. (1242 aa)
G1R2U7_NOMLEUncharacterized protein. (5430 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
PRMT1Methyltransf_25 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (323 aa)
DIPK2ADivergent protein kinase domain 2A. (430 aa)
LRP2LDL receptor related protein 2. (4624 aa)
PTCD2Pentatricopeptide repeat domain 2. (388 aa)
SRFSerum response factor. (508 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1151 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
RARBRetinoic acid receptor beta. (448 aa)
ACTN2Actinin alpha 2. (854 aa)
NDRG4NDRG family member 4. (391 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (692 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
SIRT6Deacetylase sirtuin-type domain-containing protein. (215 aa)
ZIC3Uncharacterized protein. (360 aa)
SGCZSarcoglycan zeta. (312 aa)
CXADRCXADR Ig-like cell adhesion molecule. (365 aa)
PPP1R13LUncharacterized protein. (673 aa)
RARARetinoic acid receptor alpha. (458 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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