STRINGSTRING
SRC SRC CASR CASR TBX2 TBX2 AR AR PLEKHH1 PLEKHH1 EDN1 EDN1 MED1 MED1 ACVR1 ACVR1 GLI2 GLI2 SALL1 SALL1 CCL11 CCL11 TBX20 TBX20 LHX1 LHX1 GDF7 GDF7 GLI3 GLI3 DLL4 DLL4 CSF1 CSF1 RBM15 RBM15 NKX2-1 NKX2-1 TGFBR2 TGFBR2 SRF SRF RASIP1 RASIP1 EXT1 EXT1 WNT9B WNT9B ESRP2 ESRP2 KRAS KRAS PLXND1 PLXND1 HHIP HHIP DDR1 DDR1 EDNRA EDNRA CTNNB1 CTNNB1 SFRP2 SFRP2 TMEM59L TMEM59L PPP1CA PPP1CA LRP5 LRP5 NOTCH4 NOTCH4 DAG1 DAG1 LAMA1 LAMA1 BMP7 BMP7 PGR PGR WNT5A WNT5A EPHA2 EPHA2 COL4A1 COL4A1 NOTCH1 NOTCH1 CTSH CTSH WNT6 WNT6 CLIC4 CLIC4 IHH IHH CTNNBIP1 CTNNBIP1 CTSZ CTSZ DSPP DSPP PKD2 PKD2 FGF1 FGF1 DLG5 DLG5 GBX2 GBX2 ADAMTS16 ADAMTS16 FOXF1 FOXF1 GZF1 GZF1 SMAD4 SMAD4 BMP4 BMP4 TIE1 TIE1 TGFB1 TGFB1 SIX1 SIX1 BMP2 BMP2 GREB1 GREB1 HS3ST3A1 HS3ST3A1 HS3ST3B1 HS3ST3B1 MMP14 MMP14 PAX2 PAX2 BTRC BTRC GNA13 GNA13 FGF8 FGF8 HOXA11 HOXA11 ESR1 ESR1 GDF2 GDF2 CELSR1 CELSR1 EGF EGF PTCH1 PTCH1 FGFR2 FGFR2 DCHS1 DCHS1 TIMELESS TIMELESS WNT1 WNT1 VDR VDR CITED1 CITED1 MET MET NRP1 NRP1 PKHD1 PKHD1 ENG ENG PPP3R1 PPP3R1 SPRY1 SPRY1 SOX9 SOX9 SEMA3E SEMA3E SPRY2 SPRY2 CSMD2 CSMD2 STK4 STK4 ENSNLEP00000028566 ENSNLEP00000028566 GDNF GDNF DLG1 DLG1 FGF10 FGF10 LRP5L LRP5L PBX1 PBX1 RSPO2 RSPO2 NKX3-1 NKX3-1 YAP1 YAP1 TCF21 TCF21 ENSNLEP00000032543 ENSNLEP00000032543 ENSNLEP00000033486 ENSNLEP00000033486 GREB1L GREB1L LEF1 LEF1 BCL2 BCL2 PKD1 PKD1 FGF2 FGF2 CSMD1 CSMD1 PAK1 PAK1 MKS1 MKS1 AREG AREG FOXA1 FOXA1 NFATC4 NFATC4 NRARP NRARP LAMA5 LAMA5 TBX3 TBX3 KDR KDR KDM5B KDM5B EYA1 EYA1 FOXD1 FOXD1 RDH10 RDH10 PML PML WT1 WT1 SLIT2 SLIT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SRCTyrosine-protein kinase. (537 aa)
CASRCalcium sensing receptor. (1088 aa)
TBX2T-box transcription factor 2. (647 aa)
ARUncharacterized protein. (392 aa)
PLEKHH1Pleckstrin homology, MyTH4 and FERM domain containing H1. (1318 aa)
EDN1Endothelin 1. (211 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1558 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
GLI2GLI family zinc finger 2. (1589 aa)
SALL1Spalt like transcription factor 1. (1219 aa)
CCL11C-C motif chemokine. (97 aa)
TBX20T-box transcription factor 20. (447 aa)
LHX1LIM homeobox 1. (352 aa)
GDF7Growth differentiation factor 7. (450 aa)
GLI3GLI family zinc finger 3. (1502 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (692 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
RBM15RNA binding motif protein 15. (977 aa)
NKX2-1NK2 homeobox 1. (394 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
SRFSerum response factor. (508 aa)
RASIP1Ras interacting protein 1. (917 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (745 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
ESRP2Epithelial splicing regulatory protein 2. (717 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PLXND1Plexin D1. (1603 aa)
HHIPHedgehog interacting protein. (700 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (913 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
CTNNB1Catenin beta 1. (781 aa)
SFRP2Secreted frizzled related protein 2. (280 aa)
TMEM59LTransmembrane protein 59 like. (302 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
LRP5LDL receptor related protein 5. (1510 aa)
NOTCH4Uncharacterized protein. (1913 aa)
DAG1Dystroglycan 1. (895 aa)
LAMA1Laminin subunit alpha 1. (3033 aa)
BMP7Bone morphogenetic protein 7. (430 aa)
PGRUncharacterized protein. (339 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
EPHA2EPH receptor A2. (976 aa)
COL4A1Collagen type IV alpha 1 chain. (1629 aa)
NOTCH1Notch receptor 1. (2451 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (335 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (253 aa)
IHHIndian hedgehog signaling molecule. (389 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (303 aa)
DSPPUncharacterized protein. (1265 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (921 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1889 aa)
GBX2Gastrulation brain homeobox 2. (348 aa)
ADAMTS16ADAM metallopeptidase with thrombospondin type 1 motif 16. (1224 aa)
FOXF1Uncharacterized protein. (361 aa)
GZF1GDNF inducible zinc finger protein 1. (711 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1142 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SIX1SIX homeobox 1. (284 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
GREB1Growth regulating estrogen receptor binding 1. (1911 aa)
HS3ST3A1Sulfotransferase; Belongs to the sulfotransferase 1 family. (390 aa)
HS3ST3B1Sulfotransferase; Belongs to the sulfotransferase 1 family. (390 aa)
MMP14Matrix metallopeptidase 14. (586 aa)
PAX2Paired domain-containing protein. (385 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
GNA13G protein subunit alpha 13. (373 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
HOXA11Homeobox A11. (313 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
GDF2Growth differentiation factor 2. (429 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (2918 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
PTCH1Patched 1. (1446 aa)
FGFR2Fibroblast growth factor receptor. (820 aa)
DCHS1Dachsous cadherin-related 1. (3297 aa)
TIMELESSTimeless circadian regulator. (1176 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
VDRVitamin D receptor. (427 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (901 aa)
PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (4073 aa)
ENGEndoglin. (658 aa)
PPP3R1Uncharacterized protein. (189 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
SOX9SRY-box transcription factor 9. (510 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
SPRY2Sprouty RTK signaling antagonist 2. (338 aa)
CSMD2CUB and Sushi multiple domains 2. (3507 aa)
STK4Serine/threonine kinase 4. (490 aa)
ENSNLEP00000028566Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (243 aa)
GDNFTGF_BETA_2 domain-containing protein. (169 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (916 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
LRP5LUncharacterized protein. (150 aa)
PBX1PBX homeobox 1. (433 aa)
RSPO2R-spondin 2. (250 aa)
NKX3-1NK3 homeobox 1. (230 aa)
YAP1Uncharacterized protein. (418 aa)
TCF21Transcription factor 21. (179 aa)
ENSNLEP00000032543Uncharacterized protein. (168 aa)
ENSNLEP00000033486Uncharacterized protein. (126 aa)
GREB1LGREB1 like retinoic acid receptor coactivator. (1865 aa)
LEF1Lymphoid enhancer binding factor 1. (386 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
PKD1Uncharacterized protein. (270 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (287 aa)
CSMD1CUB and Sushi multiple domains 1. (3565 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
MKS1MKS transition zone complex subunit 1. (546 aa)
AREGEGF-like domain-containing protein. (274 aa)
FOXA1Uncharacterized protein. (346 aa)
NFATC4Nuclear factor of activated T cells 4. (844 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
LAMA5Laminin subunit alpha 5. (3418 aa)
TBX3T-box transcription factor 3. (743 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1367 aa)
KDM5BLysine demethylase 5B. (1529 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
FOXD1Uncharacterized protein. (241 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
PMLUncharacterized protein. (873 aa)
WT1WT1 transcription factor. (302 aa)
SLIT2Slit guidance ligand 2. (1389 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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