STRINGSTRING
EDN3 EDN3 LAMA5 LAMA5 TBX3 TBX3 NOG NOG NRP2 NRP2 ROCK1 ROCK1 DDX5 DDX5 SEMA6A SEMA6A ENSNLEP00000045113 ENSNLEP00000045113 ENSNLEP00000045603 ENSNLEP00000045603 ENSNLEP00000045640 ENSNLEP00000045640 RDH10 RDH10 SEMA4F SEMA4F NRG1 NRG1 DDX17 DDX17 CUL7 CUL7 DACT3 DACT3 PITX2 PITX2 HTR2B HTR2B SEMA5B SEMA5B SEMA4D SEMA4D RFLNB RFLNB EFNB1 EFNB1 EDN1 EDN1 ACVR1 ACVR1 EPB41L5 EPB41L5 TGFBR3L TGFBR3L TBX20 TBX20 POLR1B POLR1B MAPK3 MAPK3 OSR1 OSR1 PEF1 PEF1 WWTR1 WWTR1 G1QSA7_NOMLE G1QSA7_NOMLE LRP6 LRP6 EOMES EOMES EXT1 EXT1 HAS2 HAS2 ALX1 ALX1 KITLG KITLG EDNRA EDNRA CTNNB1 CTNNB1 FRZB FRZB NOTCH4 NOTCH4 HAND2 HAND2 CORO1C CORO1C SEMA3F SEMA3F SNAI1 SNAI1 ZFP64 ZFP64 BMP7 BMP7 SEMA3G SEMA3G ERBB4 ERBB4 WNT5A WNT5A FN1 FN1 KBTBD8 KBTBD8 NOTCH1 NOTCH1 SOX8 SOX8 WNT10A WNT10A SEMA6C SEMA6C TCOF1 TCOF1 TGFBR3 TGFBR3 S100A4 S100A4 FGF19 FGF19 DLG5 DLG5 GBX2 GBX2 ISL1 ISL1 FOXF2 FOXF2 ALDH1A2 ALDH1A2 SEMA5A SEMA5A WNT2 WNT2 SMAD4 SMAD4 WNT16 WNT16 SEMA4B SEMA4B HEYL HEYL FGFR1 FGFR1 SEMA4A SEMA4A SFRP1 SFRP1 SMO SMO BMP4 BMP4 CYP26C1 CYP26C1 SEMA6B SEMA6B SNAI2 SNAI2 TGFB1 TGFB1 NRTN NRTN FAM172A FAM172A HEY2 HEY2 BMP2 BMP2 FLNA FLNA TGFB2 TGFB2 SEMA7A SEMA7A JAG1 JAG1 SEMA3C SEMA3C PAX2 PAX2 SEMA4G SEMA4G SEMA3A SEMA3A SEMA3D SEMA3D FGF8 FGF8 NOLC1 NOLC1 CITED2 CITED2 RADIL RADIL HNRNPAB HNRNPAB RET RET RANBP3L RANBP3L MSX1 MSX1 EDNRB EDNRB HIF1A HIF1A TAPT1 TAPT1 AKNA AKNA WNT11 WNT11 SIX2 SIX2 FGFR2 FGFR2 GSC GSC KLHL12 KLHL12 LOXL2 LOXL2 HGF HGF NRP1 NRP1 ENSNLEP00000024848 ENSNLEP00000024848 SOX10 SOX10 ENG ENG BMPR1A BMPR1A LOXL3 LOXL3 TASOR TASOR ENSNLEP00000025940 ENSNLEP00000025940 GSK3B GSK3B EFNA1 EFNA1 PPP3R1 PPP3R1 SPRY1 SPRY1 SOX9 SOX9 MAPK1 MAPK1 SEMA3E SEMA3E AMER1 AMER1 ENSNLEP00000028086 ENSNLEP00000028086 PHOX2B PHOX2B GDNF GDNF PHACTR4 PHACTR4 FGF10 FGF10 TRIM28 TRIM28 FOLR1 FOLR1 ADAM15 ADAM15 TCF21 TCF21 OLFM1 OLFM1 ENSNLEP00000033749 ENSNLEP00000033749 RPS7 RPS7 SEMA4C SEMA4C STAT1 STAT1 MEF2C MEF2C ENSNLEP00000034753 ENSNLEP00000034753 LEF1 LEF1 HEY1 HEY1 ROCK2 ROCK2 LOC100601167 LOC100601167 BCL2 BCL2 WNT8A WNT8A ANXA6 ANXA6 OTUD5 OTUD5 ENSNLEP00000038754 ENSNLEP00000038754 SEMA3B SEMA3B FAM83D FAM83D CDC42 CDC42 TGFBR1 TGFBR1 ENSNLEP00000041504 ENSNLEP00000041504
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EDN3Uncharacterized protein. (211 aa)
LAMA5Laminin subunit alpha 5. (3418 aa)
TBX3T-box transcription factor 3. (743 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (930 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1359 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1047 aa)
ENSNLEP00000045113BTB domain-containing protein. (502 aa)
ENSNLEP00000045603Uncharacterized protein. (252 aa)
ENSNLEP0000004564040S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (167 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (683 aa)
NRG1Neuregulin 1. (713 aa)
DDX17DEAD-box helicase 17; Belongs to the DEAD box helicase family. (677 aa)
CUL7Cullin 7; Belongs to the cullin family. (1735 aa)
DACT3Uncharacterized protein. (181 aa)
PITX2Homeobox protein. (420 aa)
HTR2BG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (398 aa)
SEMA5BSemaphorin 5B. (1090 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (862 aa)
RFLNBRefilin B. (144 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (346 aa)
EDN1Endothelin 1. (211 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (732 aa)
TGFBR3LTransforming growth factor beta receptor 3 like. (315 aa)
TBX20T-box transcription factor 20. (447 aa)
POLR1BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1120 aa)
MAPK3Mitogen-activated protein kinase. (278 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
PEF1Penta-EF-hand domain containing 1. (284 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
G1QSA7_NOMLEUncharacterized protein. (109 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
EOMESEomesodermin. (705 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (745 aa)
HAS2Hyaluronan synthase 2. (552 aa)
ALX1ALX homeobox 1. (326 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
CTNNB1Catenin beta 1. (781 aa)
FRZBFrizzled related protein. (325 aa)
NOTCH4Uncharacterized protein. (1913 aa)
HAND2Heart and neural crest derivatives expressed 2. (198 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (444 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (788 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
ZFP64ZFP64 zinc finger protein. (656 aa)
BMP7Bone morphogenetic protein 7. (430 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (782 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
FN1Fibronectin 1. (2477 aa)
KBTBD8Kelch repeat and BTB domain containing 8. (601 aa)
NOTCH1Notch receptor 1. (2451 aa)
SOX8SRY-box transcription factor 8. (446 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
SEMA6CSemaphorin 6C; Belongs to the semaphorin family. (921 aa)
TCOF1Treacle ribosome biogenesis factor 1. (1467 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
S100A4Protein S100; Belongs to the S-100 family. (101 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1889 aa)
GBX2Gastrulation brain homeobox 2. (348 aa)
ISL1ISL LIM homeobox 1. (349 aa)
FOXF2Uncharacterized protein. (265 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
SEMA5ASemaphorin 5A. (1074 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (836 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (279 aa)
FGFR1Fibroblast growth factor receptor. (835 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (758 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (683 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
CYP26C1Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (522 aa)
SEMA6BSemaphorin 6B; Belongs to the semaphorin family. (857 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
NRTNNeurturin. (197 aa)
FAM172AFamily with sequence similarity 172 member A. (416 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
FLNAFilamin A. (2626 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (664 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1157 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (751 aa)
PAX2Paired domain-containing protein. (385 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (793 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (771 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (777 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
NOLC1Nucleolar and coiled-body phosphoprotein 1. (710 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
RADILRap associating with DIL domain. (1034 aa)
HNRNPABRRM domain-containing protein. (187 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1114 aa)
RANBP3LRAN binding protein 3 like. (490 aa)
MSX1Msh homeobox 1. (303 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (532 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
TAPT1Transmembrane anterior posterior transformation 1. (567 aa)
AKNAAT-hook transcription factor. (1395 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
SIX2SIX homeobox 2. (293 aa)
FGFR2Fibroblast growth factor receptor. (820 aa)
GSCGoosecoid homeobox. (257 aa)
KLHL12Kelch like family member 12. (568 aa)
LOXL2Lysyl oxidase like 2. (710 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (901 aa)
ENSNLEP00000024848RRM domain-containing protein. (157 aa)
SOX10HMG box domain-containing protein. (236 aa)
ENGEndoglin. (658 aa)
BMPR1ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
LOXL3Lysyl oxidase like 3. (753 aa)
TASORTranscription activation suppressor. (1609 aa)
ENSNLEP00000025940Uncharacterized protein. (249 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (204 aa)
PPP3R1Uncharacterized protein. (189 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
SOX9SRY-box transcription factor 9. (510 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
AMER1Uncharacterized protein. (805 aa)
ENSNLEP00000028086Fork-head domain-containing protein. (459 aa)
PHOX2BPaired like homeobox 2B. (314 aa)
GDNFTGF_BETA_2 domain-containing protein. (169 aa)
PHACTR4Phosphatase and actin regulator. (512 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
TRIM28Tripartite motif containing 28. (808 aa)
FOLR1Folate receptor alpha. (228 aa)
ADAM15Uncharacterized protein. (670 aa)
TCF21Transcription factor 21. (179 aa)
OLFM1Olfactomedin 1. (488 aa)
ENSNLEP0000003374940S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (194 aa)
RPS740S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (194 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (833 aa)
STAT1Signal transducer and activator of transcription. (780 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
ENSNLEP00000034753Uncharacterized protein. (428 aa)
LEF1Lymphoid enhancer binding factor 1. (386 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (308 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
LOC10060116740S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (180 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
ANXA6Annexin. (673 aa)
OTUD5OTU deubiquitinase 5. (542 aa)
ENSNLEP00000038754F-box domain-containing protein. (392 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (770 aa)
FAM83DFamily with sequence similarity 83 member D. (613 aa)
CDC42Cell division cycle 42. (191 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
ENSNLEP0000004150440S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (179 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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