STRINGSTRING
KITLG KITLG ELL3 ELL3 ALX1 ALX1 WNT3 WNT3 EXT1 EXT1 SRF SRF EOMES EOMES LRP6 LRP6 LIF LIF G1QSA7_NOMLE G1QSA7_NOMLE ZIC3 ZIC3 HOXB4 HOXB4 PEF1 PEF1 OSR1 OSR1 SEMA5B SEMA5B CDX2 CDX2 TBX2 TBX2 SEMA4D SEMA4D SH2B3 SH2B3 EFNB1 EFNB1 MAPK3 MAPK3 PUM1 PUM1 SOX17 SOX17 JARID2 JARID2 ACVR1 ACVR1 MED1 MED1 NOG NOG TBX3 TBX3 LAMA5 LAMA5 ENSNLEP00000042003 ENSNLEP00000042003 EDN3 EDN3 UFL1 UFL1 ENSNLEP00000041504 ENSNLEP00000041504 CDC42 CDC42 FOXA1 FOXA1 ENSNLEP00000039409 ENSNLEP00000039409 SEMA3B SEMA3B ENSNLEP00000038754 ENSNLEP00000038754 FOXO4 FOXO4 OTUD5 OTUD5 ANXA6 ANXA6 ENSNLEP00000034753 ENSNLEP00000034753 MEF2C MEF2C MEOX1 MEOX1 WNT8A WNT8A BCL2 BCL2 LOC100601167 LOC100601167 SEMA4F SEMA4F TP63 TP63 ENSNLEP00000032791 ENSNLEP00000032791 SEMA4C SEMA4C RPS7 RPS7 ENSNLEP00000033749 ENSNLEP00000033749 SETD2 SETD2 HIF1A HIF1A PITX2 PITX2 HTR2B HTR2B ENSNLEP00000047072 ENSNLEP00000047072 MYOCD MYOCD MLLT3 MLLT3 NRG1 NRG1 RDH10 RDH10 ENSNLEP00000045640 ENSNLEP00000045640 ENSNLEP00000045603 ENSNLEP00000045603 ENSNLEP00000045113 ENSNLEP00000045113 SEMA6A SEMA6A CHD2 CHD2 NRP2 NRP2 LOC100588616 LOC100588616 SETD6 SETD6 FOLR1 FOLR1 ENSNLEP00000029998 ENSNLEP00000029998 EPCAM EPCAM EZH2 EZH2 PHACTR4 PHACTR4 GDNF GDNF LIN28A LIN28A PHOX2B PHOX2B ENSNLEP00000028086 ENSNLEP00000028086 SEMA3E SEMA3E GPM6A GPM6A MAPK1 MAPK1 SOX9 SOX9 ERCC2 ERCC2 ENSNLEP00000025940 ENSNLEP00000025940 BMPR1A BMPR1A METTL5 METTL5 SOX10 SOX10 ENSNLEP00000024738 ENSNLEP00000024738 NRP1 NRP1 MAPK14 MAPK14 CDK6 CDK6 NAP1L2 NAP1L2 BBS12 BBS12 KLHL12 KLHL12 ZNF281 ZNF281 PTPRC PTPRC LMBR1L LMBR1L SP7 SP7 GSC GSC PHF19 PHF19 FGFR2 FGFR2 TAPT1 TAPT1 BATF BATF EDNRB EDNRB MSX1 MSX1 RET RET PHF5A PHF5A RADIL RADIL ESR1 ESR1 CITED2 CITED2 NOLC1 NOLC1 SEMA3D SEMA3D SEMA3A SEMA3A SEMA4G SEMA4G PAX2 PAX2 SEMA3C SEMA3C JAG1 JAG1 SEMA7A SEMA7A ZFP36 ZFP36 TGFB2 TGFB2 FAM172A FAM172A NRTN NRTN SNAI2 SNAI2 SEMA6B SEMA6B CYP26C1 CYP26C1 SMO SMO SFRP1 SFRP1 SEMA4A SEMA4A SEMA4B SEMA4B SMAD4 SMAD4 SEMA5A SEMA5A TBXT TBXT ALDH1A2 ALDH1A2 ISL1 ISL1 GREM1 GREM1 GBX2 GBX2 MTF2 MTF2 FGF19 FGF19 TCOF1 TCOF1 SOX18 SOX18 SEMA6C SEMA6C SLC9A1 SLC9A1 NELFB NELFB WNT10A WNT10A REST REST SOX8 SOX8 KIT KIT NOTCH1 NOTCH1 MSI2 MSI2 KBTBD8 KBTBD8 XRCC5 XRCC5 FN1 FN1 HESX1 HESX1 ERBB4 ERBB4 SEMA3G SEMA3G SEMA3F SEMA3F GATA6 GATA6 CORO1C CORO1C HAND2 HAND2 FRZB FRZB SHC4 SHC4 PSMD11 PSMD11 HOXD4 HOXD4 SFRP2 SFRP2 CTNNB1 CTNNB1 EDNRA EDNRA EDN1 EDN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
ELL3Elongation factor for RNA polymerase II 3. (397 aa)
ALX1ALX homeobox 1. (326 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (745 aa)
SRFSerum response factor. (508 aa)
EOMESEomesodermin. (705 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
G1QSA7_NOMLEUncharacterized protein. (109 aa)
ZIC3Uncharacterized protein. (360 aa)
HOXB4Homeobox B4. (251 aa)
PEF1Penta-EF-hand domain containing 1. (284 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
SEMA5BSemaphorin 5B. (1090 aa)
CDX2Caudal type homeobox 2. (309 aa)
TBX2T-box transcription factor 2. (647 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (862 aa)
SH2B3SH2B adaptor protein 3. (567 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (346 aa)
MAPK3Mitogen-activated protein kinase. (278 aa)
PUM1Pumilio RNA binding family member 1. (1224 aa)
SOX17SRY-box transcription factor 17. (410 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1225 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1558 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
TBX3T-box transcription factor 3. (743 aa)
LAMA5Laminin subunit alpha 5. (3418 aa)
ENSNLEP00000042003MTS domain-containing protein. (151 aa)
EDN3Uncharacterized protein. (211 aa)
UFL1UFM1 specific ligase 1. (794 aa)
ENSNLEP0000004150440S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (179 aa)
CDC42Cell division cycle 42. (191 aa)
FOXA1Uncharacterized protein. (346 aa)
ENSNLEP00000039409MTS domain-containing protein. (203 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (770 aa)
ENSNLEP00000038754F-box domain-containing protein. (392 aa)
FOXO4Forkhead box O4. (505 aa)
OTUD5OTU deubiquitinase 5. (542 aa)
ANXA6Annexin. (673 aa)
ENSNLEP00000034753Uncharacterized protein. (428 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
MEOX1Mesenchyme homeobox 1. (245 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
LOC10060116740S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (180 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (683 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
ENSNLEP00000032791Uncharacterized protein. (198 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (833 aa)
RPS740S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (194 aa)
ENSNLEP0000003374940S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (194 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2498 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
PITX2Homeobox protein. (420 aa)
HTR2BG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (398 aa)
ENSNLEP00000047072CCHC-type domain-containing protein. (196 aa)
MYOCDMyocardin. (986 aa)
MLLT3MLLT3 super elongation complex subunit. (568 aa)
NRG1Neuregulin 1. (713 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
ENSNLEP0000004564040S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (167 aa)
ENSNLEP00000045603Uncharacterized protein. (252 aa)
ENSNLEP00000045113BTB domain-containing protein. (502 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1047 aa)
CHD2Uncharacterized protein. (1816 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (930 aa)
LOC100588616Runt domain-containing protein. (504 aa)
SETD6N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily. (449 aa)
FOLR1Folate receptor alpha. (228 aa)
ENSNLEP00000029998CCHC-type domain-containing protein. (202 aa)
EPCAMEpithelial cell adhesion molecule. (320 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
PHACTR4Phosphatase and actin regulator. (512 aa)
GDNFTGF_BETA_2 domain-containing protein. (169 aa)
LIN28ALin-28 homolog A. (209 aa)
PHOX2BPaired like homeobox 2B. (314 aa)
ENSNLEP00000028086Fork-head domain-containing protein. (459 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
GPM6AGlycoprotein M6A. (278 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
SOX9SRY-box transcription factor 9. (510 aa)
ERCC2Helicase ATP-binding domain-containing protein. (625 aa)
ENSNLEP00000025940Uncharacterized protein. (249 aa)
BMPR1ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
METTL5MTS domain-containing protein. (244 aa)
SOX10HMG box domain-containing protein. (236 aa)
ENSNLEP00000024738DMA domain-containing protein. (449 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (901 aa)
MAPK14Mitogen-activated protein kinase. (321 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
NAP1L2Nucleosome assembly protein 1 like 2; Belongs to the nucleosome assembly protein (NAP) family. (462 aa)
BBS12Bardet-Biedl syndrome 12. (710 aa)
KLHL12Kelch like family member 12. (568 aa)
ZNF281Zinc finger protein 281. (858 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1304 aa)
LMBR1LLimb development membrane protein 1 like; Belongs to the LIMR family. (490 aa)
SP7Sp7 transcription factor. (431 aa)
GSCGoosecoid homeobox. (257 aa)
PHF19PHD finger protein 19. (599 aa)
FGFR2Fibroblast growth factor receptor. (820 aa)
TAPT1Transmembrane anterior posterior transformation 1. (567 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (532 aa)
MSX1Msh homeobox 1. (303 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1114 aa)
PHF5AUncharacterized protein. (81 aa)
RADILRap associating with DIL domain. (1034 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
NOLC1Nucleolar and coiled-body phosphoprotein 1. (710 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (777 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (771 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (793 aa)
PAX2Paired domain-containing protein. (385 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (751 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1157 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (664 aa)
ZFP36ZFP36 ring finger protein. (322 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
FAM172AFamily with sequence similarity 172 member A. (416 aa)
NRTNNeurturin. (197 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
SEMA6BSemaphorin 6B; Belongs to the semaphorin family. (857 aa)
CYP26C1Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (522 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (683 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (758 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (836 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SEMA5ASemaphorin 5A. (1074 aa)
TBXTT-box transcription factor T. (435 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
ISL1ISL LIM homeobox 1. (349 aa)
GREM1CTCK domain-containing protein. (143 aa)
GBX2Gastrulation brain homeobox 2. (348 aa)
MTF2Metal response element binding transcription factor 2. (593 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
TCOF1Treacle ribosome biogenesis factor 1. (1467 aa)
SOX18SRY-box transcription factor 18. (362 aa)
SEMA6CSemaphorin 6C; Belongs to the semaphorin family. (921 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (809 aa)
NELFBUncharacterized protein. (544 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
RESTRE1 silencing transcription factor. (1097 aa)
SOX8SRY-box transcription factor 8. (446 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (969 aa)
NOTCH1Notch receptor 1. (2451 aa)
MSI2Musashi RNA binding protein 2. (311 aa)
KBTBD8Kelch repeat and BTB domain containing 8. (601 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
FN1Fibronectin 1. (2477 aa)
HESX1HESX homeobox 1. (185 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (782 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (788 aa)
GATA6Uncharacterized protein. (452 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (444 aa)
HAND2Heart and neural crest derivatives expressed 2. (198 aa)
FRZBFrizzled related protein. (325 aa)
SHC4SHC adaptor protein 4. (604 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
HOXD4Homeobox D4. (255 aa)
SFRP2Secreted frizzled related protein 2. (280 aa)
CTNNB1Catenin beta 1. (781 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
EDN1Endothelin 1. (211 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
Server load: low (30%) [HD]