55 items (Nomascus leucogenys) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	DUOX1	Dual oxidase 1. (1505 aa)
	FMO5	Dimethylaniline monooxygenase [N-oxide-forming]. (533 aa)
	NOS1	Nitric oxide synthase; Produces nitric oxide (NO). (1425 aa)
	TP53I3	Tumor protein p53 inducible protein 3. (346 aa)
	HSD11B1	Hydroxysteroid 11-beta dehydrogenase 1. (291 aa)
	NOS2	Nitric oxide synthase; Produces nitric oxide (NO). (1153 aa)
	PNMA8B	PNMA family member 8B. (629 aa)
	NOS3	Nitric oxide synthase; Produces nitric oxide (NO). (1128 aa)
	CRYZL1	Crystallin zeta like 1. (349 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (335 aa)
	CBR3	Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (277 aa)
	DUS2	Dihydrouridine synthase 2. (490 aa)
	TM7SF2	Transmembrane 7 superfamily member 2. (380 aa)
	ASPDH	Aspartate dehydrogenase domain containing. (283 aa)
	POR	NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (680 aa)
	NDOR1	NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (595 aa)
	H6PD	Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. (762 aa)
	CRYZ	Crystallin zeta. (329 aa)
	GLYR1	Glyoxylate reductase 1 homolog. (557 aa)
	NNT	Nicotinamide nucleotide transhydrogenase. (1086 aa)
	GAPDHS	Glyceraldehyde-3-phosphate dehydrogenase. (409 aa)
	SRD5A1	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (259 aa)
	MTRR	5-methyltetrahydrofolate-homocysteine methyltransferase reductase. (698 aa)
	GSR	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (522 aa)
	ME1	Malic enzyme. (572 aa)
	DHFR	DHFR domain-containing protein. (135 aa)
	NOX5	NADPH oxidase 5. (763 aa)
	G6PD	Uncharacterized protein. (452 aa)
	HIBADH	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (336 aa)
	LOC100605282	Dimethylaniline monooxygenase [N-oxide-forming]. (487 aa)
	FMO3	Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
	FMO2	Dimethylaniline monooxygenase [N-oxide-forming]. (535 aa)
	FMO1	Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
	FMO4	Dimethylaniline monooxygenase [N-oxide-forming]. (558 aa)
	ME3	Malic enzyme. (604 aa)
	QDPR	Quinoid dihydropteridine reductase. (244 aa)
	CAT	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
	ENSNLEP00000024940	PKS_ER domain-containing protein. (288 aa)
	ENSNLEP00000026090	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (258 aa)
	GRHPR	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (340 aa)
	DHCR7	7-dehydrocholesterol reductase. (475 aa)
	SPR	Sepiapterin reductase. (261 aa)
	ENSNLEP00000033650	Uncharacterized protein. (479 aa)
	ENSNLEP00000033717	Gp_dh_C domain-containing protein. (180 aa)
	CRYM	Crystallin mu. (293 aa)
	ENSNLEP00000035227	DHFR domain-containing protein. (159 aa)
	KCNAB1	Potassium voltage-gated channel subfamily A member regulatory beta subunit 1. (419 aa)
	DECR1	2,4-dienoyl-CoA reductase 1. (326 aa)
	LBR	Lamin B receptor. (615 aa)
	NOX1	NADPH oxidase 1. (564 aa)
	GMDS	GDP-mannose 4,6-dehydratase. (372 aa)
	CBR4	Carbonyl reductase 4. (237 aa)
	HMGCR	3-hydroxy-3-methylglutaryl coenzyme A reductase. (893 aa)
	PGD	6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (481 aa)
	MTHFR	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (654 aa)

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAT	DECR1	ENSNLEP00000021774	ENSNLEP00000037475	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	2,4-dienoyl-CoA reductase 1.	0.414
CAT	GSR	ENSNLEP00000021774	ENSNLEP00000014518	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.581
CAT	H6PD	ENSNLEP00000021774	ENSNLEP00000011290	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase.	0.532
CAT	MTRR	ENSNLEP00000021774	ENSNLEP00000014050	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	5-methyltetrahydrofolate-homocysteine methyltransferase reductase.	0.446
CAT	NDOR1	ENSNLEP00000021774	ENSNLEP00000011120	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	0.440
CAT	NOS1	ENSNLEP00000021774	ENSNLEP00000000357	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Nitric oxide synthase; Produces nitric oxide (NO).	0.446
CAT	NOS2	ENSNLEP00000021774	ENSNLEP00000002093	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Nitric oxide synthase; Produces nitric oxide (NO).	0.446
CAT	NOS3	ENSNLEP00000021774	ENSNLEP00000004866	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Nitric oxide synthase; Produces nitric oxide (NO).	0.446
CAT	POR	ENSNLEP00000021774	ENSNLEP00000010431	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	0.446
CBR3	CBR4	ENSNLEP00000005296	ENSNLEP00000043406	Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Carbonyl reductase 4.	0.452
CBR4	CBR3	ENSNLEP00000043406	ENSNLEP00000005296	Carbonyl reductase 4.	Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.452
CBR4	H6PD	ENSNLEP00000043406	ENSNLEP00000011290	Carbonyl reductase 4.	Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase.	0.404
DECR1	CAT	ENSNLEP00000037475	ENSNLEP00000021774	2,4-dienoyl-CoA reductase 1.	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	0.414
DHCR7	HMGCR	ENSNLEP00000027443	ENSNLEP00000044847	7-dehydrocholesterol reductase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.705
DHFR	GSR	ENSNLEP00000015759	ENSNLEP00000014518	DHFR domain-containing protein.	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.515
DHFR	H6PD	ENSNLEP00000015759	ENSNLEP00000011290	DHFR domain-containing protein.	Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase.	0.495
DHFR	MTHFR	ENSNLEP00000015759	ENSNLEP00000046785	DHFR domain-containing protein.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.453
DHFR	QDPR	ENSNLEP00000015759	ENSNLEP00000020129	DHFR domain-containing protein.	Quinoid dihydropteridine reductase.	0.947
DHFR	SPR	ENSNLEP00000015759	ENSNLEP00000028927	DHFR domain-containing protein.	Sepiapterin reductase.	0.948
DUOX1	NOS3	ENSNLEP00000049317	ENSNLEP00000004866	Dual oxidase 1.	Nitric oxide synthase; Produces nitric oxide (NO).	0.456

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