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| | SMO | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (683 aa) |
| | WNT16 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | WNT2 | Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa) |
| | SEMA5A | Semaphorin 5A. (1074 aa) |
| | CAV2 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (86 aa) |
| | COL8A2 | C1q domain-containing protein. (409 aa) |
| | FST | Follistatin. (317 aa) |
| | SERPINB1 | Serpin family B member 1; Belongs to the serpin family. (379 aa) |
| | C6orf89 | Chromosome 6 open reading frame 89. (356 aa) |
| | TGFA | Transforming growth factor alpha. (166 aa) |
| | FGF1 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa) |
| | BCL2L1 | BCL2 like 1. (217 aa) |
| | RPS6KA1 | Ribosomal protein S6 kinase. (744 aa) |
| | NKX6-1 | NK6 homeobox 1. (368 aa) |
| | ACVR2A | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa) |
| | RASGRF1 | Ras protein specific guanine nucleotide releasing factor 1. (1243 aa) |
| | FSHR | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa) |
| | KIT | Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (969 aa) |
| | NOTCH1 | Notch receptor 1. (2451 aa) |
| | EREG | Epiregulin. (169 aa) |
| | EPHA2 | EPH receptor A2. (976 aa) |
| | IGFBP5 | Insulin like growth factor binding protein 5. (272 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) |
| | IFT52 | Intraflagellar transport 52. (396 aa) |
| | FGF7 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa) |
| | OVOL1 | Ovo like transcriptional repressor 1. (267 aa) |
| | KLK8 | Kallikrein related peptidase 8; Belongs to the peptidase S1 family. (305 aa) |
| | CTNNB1 | Catenin beta 1. (781 aa) |
| | NOTCH2 | Notch receptor 2. (2444 aa) |
| | ESRP2 | Epithelial splicing regulatory protein 2. (717 aa) |
| | ST8SIA1 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (356 aa) |
| | CCN3 | Cellular communication network factor 3. (357 aa) |
| | BAX | Uncharacterized protein. (194 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa) |
| | HSF4 | Heat shock transcription factor 4. (417 aa) |
| | A4GNT | Alpha-1,4-N-acetylglucosaminyltransferase. (327 aa) |
| | NKX2-8 | NK2 homeobox 8. (229 aa) |
| | CYP7B1 | Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (506 aa) |
| | IFT172 | Intraflagellar transport 172. (1703 aa) |
| | PROK1 | Prokineticin 1. (105 aa) |
| | RB1 | RB transcriptional corepressor 1. (919 aa) |
| | MAP2K2 | Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (383 aa) |
| | FGL1 | Fibrinogen like 1. (312 aa) |
| | IGFBP4 | Insulin like growth factor binding protein 4. (258 aa) |
| | MKI67 | Marker of proliferation Ki-67. (3255 aa) |
| | CD34 | CD34 molecule. (385 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (423 aa) |
| | CALCA | Calcitonin related polypeptide alpha. (141 aa) |
| | SDR16C5 | Short chain dehydrogenase/reductase family 16C member 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (309 aa) |
| | MED1 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1558 aa) |
| | NKX2-5 | NK2 homeobox 5. (317 aa) |
| | TBX2 | T-box transcription factor 2. (647 aa) |
| | PDX1 | Pancreatic and duodenal homeobox 1. (283 aa) |
| | VSTM4 | V-set and transmembrane domain containing 4. (320 aa) |
| | NKX2-6 | NK2 homeobox 6. (301 aa) |
| | DACH1 | Dachshund family transcription factor 1. (760 aa) |
| | TEK | TEK receptor tyrosine kinase. (1124 aa) |
| | LOC100607937 | Uncharacterized protein. (600 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa) |
| | PTCH1 | Patched 1. (1446 aa) |
| | FGFR2 | Fibroblast growth factor receptor. (820 aa) |
| | AGAP2 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1186 aa) |
| | STAT6 | Signal transducer and activator of transcription. (842 aa) |
| | KRT2 | Keratin 2; Belongs to the intermediate filament family. (629 aa) |
| | LGR4 | Leucine rich repeat containing G protein-coupled receptor 4. (929 aa) |
| | FSHB | Follicle stimulating hormone beta subunit. (129 aa) |
| | ZEB1 | Zinc finger E-box binding homeobox 1. (1105 aa) |
| | SFN | Stratifin; Belongs to the 14-3-3 family. (248 aa) |
| | LOXL2 | Lysyl oxidase like 2. (710 aa) |
| | PPARD | Peroxisome proliferator activated receptor delta. (441 aa) |
| | HGF | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa) |
| | CDKN1B | Uncharacterized protein. (204 aa) |
| | SERPINF1 | Serpin family F member 1; Belongs to the serpin family. (366 aa) |
| | TNFSF11 | Tumor necrosis factor ligand superfamily member. (317 aa) |
| | BMPR1A | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa) |
| | STK3 | Serine/threonine kinase 3. (519 aa) |
| | SOX9 | SRY-box transcription factor 9. (510 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa) |
| | IFT57 | Intraflagellar transport 57. (429 aa) |
| | PHOX2B | Paired like homeobox 2B. (314 aa) |
| | AR | Uncharacterized protein. (392 aa) |
| | LIMS2 | LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (365 aa) |
| | MEF2C | Myocyte enhancer factor 2C. (483 aa) |
| | LIPA | Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (399 aa) |
| | WDR77 | WD repeat domain 77. (347 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (182 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1206 aa) |
| | SAV1 | Salvador family WW domain containing protein 1. (384 aa) |
| | COL8A1 | Collagen type VIII alpha 1 chain. (744 aa) |
| | FABP7 | Fatty acid binding protein 7; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (165 aa) |
| | BAD | Uncharacterized protein. (82 aa) |
| | B4GALT1 | Beta-1,4-galactosyltransferase 1. (361 aa) |
| | STK4 | Serine/threonine kinase 4. (490 aa) |
| | EAF2 | ELL associated factor 2. (263 aa) |
| | AREG | EGF-like domain-containing protein. (274 aa) |
| | NF1 | Neurofibromin 1. (2839 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa) |
| | EFNB2 | Ephrin B2; Belongs to the ephrin family. (299 aa) |
| | NRARP | NOTCH regulated ankyrin repeat protein. (114 aa) |
| | BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa) |
| | ENSNLEP00000041841 | BTB domain-containing protein. (408 aa) |
| | HMX2 | H6 family homeobox 2. (262 aa) |
| | NOG | Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa) |
| | ENSNLEP00000042936 | Protein kinase domain-containing protein. (201 aa) |
| | XBP1 | BZIP domain-containing protein. (376 aa) |
| | SCARB1 | Scavenger receptor class B member 1; Belongs to the CD36 family. (550 aa) |
| | IGFBP3 | Insulin like growth factor binding protein 3. (267 aa) |
| | KDR | Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1367 aa) |
| | PROK2 | Prokineticin 2. (129 aa) |
| | EYA1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa) |
| | TRIM24 | Tripartite motif containing 24. (1049 aa) |
| | LGR5 | Leucine rich repeat containing G protein-coupled receptor 5. (907 aa) |
| | IRS2 | Insulin receptor substrate 2. (1344 aa) |
| | ITGB1BP1 | Integrin subunit beta 1 binding protein 1. (200 aa) |
| | IL6 | Uncharacterized protein. (258 aa) |
| | SIDT2 | SID1 transmembrane family member 2. (808 aa) |
| | TNF | Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa) |
| | MTA3 | Metastasis associated 1 family member 3. (594 aa) |
| | DLG1 | Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (916 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | MTSS1 | MTSS I-BAR domain containing 1. (759 aa) |
| | DRD2 | Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (445 aa) |
| | IFT80 | Intraflagellar transport 80. (777 aa) |
| | NKX3-1 | NK3 homeobox 1. (230 aa) |
| | PSEN1 | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa) |
| | BTBD10 | BTB domain containing 10. (483 aa) |
| | LOC100588616 | Runt domain-containing protein. (504 aa) |
| | CD109 | CD109 molecule. (1405 aa) |
| | YAP1 | Uncharacterized protein. (418 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (295 aa) |
| | CAV1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa) |
| | ENSNLEP00000032543 | Uncharacterized protein. (168 aa) |
| | FAP | Fibroblast activation protein alpha; Belongs to the peptidase S9B family. (760 aa) |
| | TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa) |
| | ENSNLEP00000033330 | Uncharacterized protein. (193 aa) |
| | IQGAP3 | Uncharacterized protein. (2344 aa) |
| | EHF | ETS homologous factor. (322 aa) |
| | IRF6 | Interferon regulatory factor 6. (467 aa) |
| | BMPER | BMP binding endothelial regulator. (685 aa) |
| | ESR1 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa) |
| | ERN1 | Endoplasmic reticulum to nucleus signaling 1. (977 aa) |
| | BTRC | Beta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa) |
| | PROX1 | Prospero homeobox 1. (737 aa) |
| | FERMT1 | Fermitin family member 1. (587 aa) |
| | HLX | H2.0 like homeobox. (441 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | NCSTN | Nicastrin. (702 aa) |
| | FLCN | Folliculin. (542 aa) |
| | NOX5 | NADPH oxidase 5. (763 aa) |
| | FGF9 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | ID2 | Inhibitor of DNA binding 2. (134 aa) |
| | THAP1 | THAP domain containing 1. (213 aa) |
| | BMP4 | Bone morphogenetic protein 4. (408 aa) |
