STRINGSTRING
CYP7B1 CYP7B1 ST8SIA1 ST8SIA1 ESRP2 ESRP2 HAS2 HAS2 CDH3 CDH3 GRN GRN NOTCH2 NOTCH2 GHSR GHSR MYC MYC EMC10 EMC10 CTNNB1 CTNNB1 CCR3 CCR3 FGF7 FGF7 ITGA4 ITGA4 PLCG1 PLCG1 SRSF6 SRSF6 HRH4 HRH4 CLDN1 CLDN1 MST1 MST1 HYAL1 HYAL1 MMP12 MMP12 WNT5A WNT5A JAML JAML BTK BTK ODAM ODAM STXBP4 STXBP4 HRAS HRAS NOTCH1 NOTCH1 CCL24 CCL24 CCL26 CCL26 IHH IHH PIK3CD PIK3CD VEGFD VEGFD LOC100592336 LOC100592336 ID1 ID1 LOC100595279 LOC100595279 ERBB2 ERBB2 HIF1A HIF1A HTR2B HTR2B MTA3 MTA3 EPGN EPGN TNF TNF LOC100582337 LOC100582337 IRS2 IRS2 ZNF703 ZNF703 SCN5A SCN5A PLXNB3 PLXNB3 HMOX1 HMOX1 IGF1 IGF1 EYA1 EYA1 KDM5B KDM5B KDR KDR XBP1 XBP1 AGTR1 AGTR1 NRP2 NRP2 NOG NOG HTRA1 HTRA1 HMX2 HMX2 BMPR2 BMPR2 MYDGF MYDGF NRARP NRARP TGFBR1 TGFBR1 CDC42 CDC42 LOC100593010 LOC100593010 NRAS NRAS NF1 NF1 AREG AREG ENSNLEP00000039670 ENSNLEP00000039670 LACRT LACRT CXCL12 CXCL12 B4GALT1 B4GALT1 BAD BAD IL18 IL18 ENSNLEP00000037750 ENSNLEP00000037750 RREB1 RREB1 FGF2 FGF2 EGFR EGFR TNFSF12 TNFSF12 OSR2 OSR2 ENSNLEP00000034753 ENSNLEP00000034753 PTPRN PTPRN VEGFA VEGFA IL10 IL10 ENSNLEP00000033551 ENSNLEP00000033551 IQGAP3 IQGAP3 TP63 TP63 PGF PGF ENSNLEP00000032543 ENSNLEP00000032543 ITGB3 ITGB3 HPN HPN CCND1 CCND1 YAP1 YAP1 LOC100588616 LOC100588616 FZD7 FZD7 RPTOR RPTOR IGF2 IGF2 ZNF304 ZNF304 LRG1 LRG1 FGF10 FGF10 AKT1 AKT1 ENSNLEP00000027457 ENSNLEP00000027457 ENSNLEP00000027393 ENSNLEP00000027393 SOX9 SOX9 PPP1R16B PPP1R16B PTN PTN RESP18 RESP18 TACR1 TACR1 WNT3A WNT3A BMPR1A BMPR1A PKHD1 PKHD1 NRP1 NRP1 M3ZBW0_NOMLE M3ZBW0_NOMLE AGGF1 AGGF1 AKT3 AKT3 C5AR1 C5AR1 LAMC1 LAMC1 GLUL GLUL ACVRL1 ACVRL1 NR4A1 NR4A1 SAAL1 SAAL1 SP1 SP1 AGAP2 AGAP2 NR4A3 NR4A3 JCAD JCAD FGFR2 FGFR2 VEGFC VEGFC EGF EGF TEK TEK NODAL NODAL DLX5 DLX5 NKX2-6 NKX2-6 TCF7L2 TCF7L2 EGR3 EGR3 PRKD1 PRKD1 GDF2 GDF2 VIP VIP TGM1 TGM1 PDGFB PDGFB TNFAIP3 TNFAIP3 PAX2 PAX2 JUN JUN VASH2 VASH2 PROX1 PROX1 ARG1 ARG1 GATA2 GATA2 BMP2 BMP2 HLX HLX TGFB1 TGFB1 ADAM17 ADAM17 FGF9 FGF9 MAP2K5 MAP2K5 THBS4 THBS4 BMP4 BMP4 SMO SMO SFRP1 SFRP1 APLNR APLNR FGFR1 FGFR1 SIRT1 SIRT1 BMP6 BMP6 WNT2 WNT2 SEMA5A SEMA5A STAT3 STAT3 CAV2 CAV2 F3 F3 CRNN CRNN TGFA TGFA SPINK1 SPINK1 ARNT ARNT ECM1 ECM1 FGF1 FGF1 SCG2 SCG2 VEGFB VEGFB ZBED9 ZBED9 GHRL GHRL HSF4 HSF4 PROK1 PROK1 BMP5 BMP5 SIRT6 SIRT6 PRKD2 PRKD2 FLT4 FLT4 OSR1 OSR1 CCL11 CCL11 ATP7A ATP7A REG3A REG3A REG3G REG3G NOD2 NOD2 MED1 MED1 AR AR NKX2-5 NKX2-5 PDX1 PDX1 PRKCA PRKCA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (506 aa)
ST8SIA1ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (356 aa)
ESRP2Epithelial splicing regulatory protein 2. (717 aa)
HAS2Hyaluronan synthase 2. (552 aa)
CDH3Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (829 aa)
GRNGranulin precursor. (593 aa)
NOTCH2Notch receptor 2. (2444 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
EMC10Uncharacterized protein. (347 aa)
CTNNB1Catenin beta 1. (781 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (361 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1182 aa)
SRSF6Serine and arginine rich splicing factor 6. (344 aa)
HRH4G_PROTEIN_RECEP_F1_2 domain-containing protein. (264 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
HYAL1Hyaluronidase. (435 aa)
MMP12Matrix metallopeptidase 12. (470 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
JAMLJunction adhesion molecule like. (394 aa)
BTKTyrosine-protein kinase. (659 aa)
ODAMOdontogenic, ameloblast associated. (279 aa)
STXBP4Syntaxin binding protein 4. (539 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
NOTCH1Notch receptor 1. (2451 aa)
CCL24C-C motif chemokine ligand 24. (118 aa)
CCL26C-C motif chemokine. (94 aa)
IHHIndian hedgehog signaling molecule. (389 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1077 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
LOC100592336PH_3 domain-containing protein. (247 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (155 aa)
LOC100595279Uncharacterized protein. (212 aa)
ERBB2Receptor protein-tyrosine kinase. (1247 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
HTR2BG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (398 aa)
MTA3Metastasis associated 1 family member 3. (594 aa)
EPGNEpithelial mitogen. (154 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
LOC100582337Nucleoside diphosphate kinase. (147 aa)
IRS2Insulin receptor substrate 2. (1344 aa)
ZNF703Zinc finger protein 703. (522 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1925 aa)
PLXNB3Plexin B3. (1842 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
IGF1IlGF domain-containing protein. (196 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
KDM5BLysine demethylase 5B. (1529 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1367 aa)
XBP1BZIP domain-containing protein. (376 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (930 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
HTRA1HtrA serine peptidase 1. (460 aa)
HMX2H6 family homeobox 2. (262 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
MYDGFMyeloid derived growth factor. (188 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
CDC42Cell division cycle 42. (191 aa)
LOC100593010Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (459 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
NF1Neurofibromin 1. (2839 aa)
AREGEGF-like domain-containing protein. (274 aa)
ENSNLEP00000039670Gln-synt_C domain-containing protein; Belongs to the glutamine synthetase family. (334 aa)
LACRTUncharacterized protein. (102 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (361 aa)
BADUncharacterized protein. (82 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
ENSNLEP00000037750Gln-synt_C domain-containing protein; Belongs to the glutamine synthetase family. (341 aa)
RREB1Ras responsive element binding protein 1. (1719 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (287 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
TNFSF12TNF superfamily member 12; Belongs to the tumor necrosis factor family. (249 aa)
OSR2Odd-skipped related transciption factor 2. (419 aa)
ENSNLEP00000034753Uncharacterized protein. (428 aa)
PTPRNProtein tyrosine phosphatase receptor type N. (955 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (393 aa)
IL10Interleukin 10. (178 aa)
ENSNLEP00000033551Uncharacterized protein. (169 aa)
IQGAP3Uncharacterized protein. (2344 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
PGFPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (225 aa)
ENSNLEP00000032543Uncharacterized protein. (168 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (806 aa)
HPNHepsin; Belongs to the peptidase S1 family. (431 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
YAP1Uncharacterized protein. (418 aa)
LOC100588616Runt domain-containing protein. (504 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1318 aa)
IGF2IlGF domain-containing protein. (180 aa)
ZNF304Zinc finger protein 304. (705 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (347 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
ENSNLEP00000027457Gln-synt_C domain-containing protein; Belongs to the glutamine synthetase family. (329 aa)
ENSNLEP00000027393Uncharacterized protein. (308 aa)
SOX9SRY-box transcription factor 9. (510 aa)
PPP1R16BProtein phosphatase 1 regulatory subunit 16B. (562 aa)
PTNPleiotrophin. (172 aa)
RESP18RESP18 domain-containing protein. (145 aa)
TACR1Tachykinin receptor 1. (406 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
BMPR1ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (4073 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (901 aa)
M3ZBW0_NOMLESH2 domain-containing protein. (230 aa)
AGGF1G-patch domain-containing protein. (679 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (350 aa)
LAMC1Laminin subunit gamma 1. (1608 aa)
GLULGlutamine synthetase. (373 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (589 aa)
SAAL1Serum amyloid A like 1. (431 aa)
SP1Sp1 transcription factor. (786 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1186 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (636 aa)
JCADJunctional cadherin 5 associated. (1354 aa)
FGFR2Fibroblast growth factor receptor. (820 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
NODALNodal growth differentiation factor. (347 aa)
DLX5Homeobox domain-containing protein. (191 aa)
NKX2-6NK2 homeobox 6. (301 aa)
TCF7L2HMG box domain-containing protein. (534 aa)
EGR3Early growth response 3. (387 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa)
GDF2Growth differentiation factor 2. (429 aa)
VIPVasoactive intestinal peptide. (170 aa)
TGM1Transglutaminase 1. (808 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (233 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
PAX2Paired domain-containing protein. (385 aa)
JUNBZIP domain-containing protein; Belongs to the bZIP family. (305 aa)
VASH2Uncharacterized protein. (251 aa)
PROX1Prospero homeobox 1. (737 aa)
ARG1Arginase. (322 aa)
GATA2GATA binding protein 2. (480 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
HLXH2.0 like homeobox. (441 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (414 aa)
THBS4Thrombospondin 4. (925 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (683 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
FGFR1Fibroblast growth factor receptor. (835 aa)
SIRT1Sirtuin 1. (734 aa)
BMP6TGF_BETA_2 domain-containing protein. (125 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
SEMA5ASemaphorin 5A. (1074 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (86 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (295 aa)
CRNNCornulin. (495 aa)
TGFATransforming growth factor alpha. (166 aa)
SPINK1Serine peptidase inhibitor, Kazal type 1. (79 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (789 aa)
ECM1Extracellular matrix protein 1. (568 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
SCG2Secretogranin II. (542 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
ZBED9Zinc finger BED-type containing 9. (1325 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
HSF4Heat shock transcription factor 4. (417 aa)
PROK1Prokineticin 1. (105 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
SIRT6Deacetylase sirtuin-type domain-containing protein. (215 aa)
PRKD2Uncharacterized protein. (716 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
CCL11C-C motif chemokine. (97 aa)
ATP7AATPase copper transporting alpha. (1460 aa)
REG3ARegenerating family member 3 alpha. (175 aa)
REG3GRegenerating family member 3 gamma. (175 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1558 aa)
ARUncharacterized protein. (392 aa)
NKX2-5NK2 homeobox 5. (317 aa)
PDX1Pancreatic and duodenal homeobox 1. (283 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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