STRINGSTRING
PTCH1 PTCH1 AQP11 AQP11 VASH1 VASH1 SPARC SPARC DAB2 DAB2 LOC100607937 LOC100607937 ALOX5 ALOX5 PEX2 PEX2 APOH APOH PDX1 PDX1 FLT1 FLT1 AR AR MED1 MED1 BRCA2 BRCA2 RGCC RGCC SLURP1 SLURP1 STK11 STK11 G1QLB3_NOMLE G1QLB3_NOMLE NUPR1 NUPR1 SYNJ2BP SYNJ2BP PRL PRL CNMD CNMD GDF2 GDF2 TINF2 TINF2 A4GNT A4GNT IL12B IL12B IL12A IL12A GHRL GHRL PDCD10 PDCD10 TBC1D31 TBC1D31 MEN1 MEN1 OVOL1 OVOL1 FBXW7 FBXW7 SFRP2 SFRP2 IFT52 IFT52 PTPRM PTPRM PHOX2B PHOX2B WNT5A WNT5A TNMD TNMD WDR13 WDR13 EREG EREG MAGED1 MAGED1 NOTCH1 NOTCH1 NLRC3 NLRC3 GDF5 GDF5 TGFBR3 TGFBR3 ISL1 ISL1 CEACAM1 CEACAM1 CAV2 CAV2 GATA3 GATA3 PTEN PTEN SFRP1 SFRP1 BMP4 BMP4 SNAI2 SNAI2 FLCN FLCN TGFB1 TGFB1 TGFB2 TGFB2 STK4 STK4 CAV1 CAV1 RIDA RIDA NFIB NFIB ENSNLEP00000033330 ENSNLEP00000033330 SULF1 SULF1 ATF2 ATF2 IRF6 IRF6 STAT1 STAT1 LIMS2 LIMS2 MEF2C MEF2C ENSNLEP00000034659 ENSNLEP00000034659 WDR77 WDR77 PPARG PPARG ATP5IF1 ATP5IF1 CDKN2A CDKN2A B2M B2M SAV1 SAV1 B4GALT1 B4GALT1 ROBO1 ROBO1 AIMP1 AIMP1 EAF2 EAF2 INTU INTU NF1 NF1 ENSNLEP00000040898 ENSNLEP00000040898 TGFBR1 TGFBR1 EFNB2 EFNB2 XDH XDH ATP5F1A ATP5F1A THBS1 THBS1 PAX6 PAX6 PTPRK PTPRK DAB2IP DAB2IP KLF9 KLF9 TRIM24 TRIM24 WNT10B WNT10B NR2F2 NR2F2 COL4A3 COL4A3 RUNX3 RUNX3 CDKN2B CDKN2B DUSP10 DUSP10 TNF TNF NKX2-8 NKX2-8 IFT172 IFT172 IL26 IL26 DLL4 DLL4 RB1 RB1 G1QS07_NOMLE G1QS07_NOMLE CPB2 CPB2 MMRN2 MMRN2 CASK CASK DLG1 DLG1 MCC MCC RAP1GAP RAP1GAP MTSS1 MTSS1 DRD2 DRD2 IFT80 IFT80 NKX3-1 NKX3-1 CD109 CD109 HPN HPN IFT57 IFT57 SOX9 SOX9 STK3 STK3 KRIT1 KRIT1 ENG ENG SERPINF1 SERPINF1 CDKN1B CDKN1B CDK6 CDK6 PPARD PPARD SOX2 SOX2 SFN SFN ZEB1 ZEB1 CDC73 CDC73 VDR VDR ACVRL1 ACVRL1 KRT4 KRT4 FGFR2 FGFR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTCH1Patched 1. (1446 aa)
AQP11Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (271 aa)
VASH1Vasohibin 1. (364 aa)
SPARCSecreted protein acidic and cysteine rich. (303 aa)
DAB2DAB adaptor protein 2. (749 aa)
LOC100607937Uncharacterized protein. (600 aa)
ALOX5Arachidonate 5-lipoxygenase. (655 aa)
PEX2Peroxisomal biogenesis factor 2. (305 aa)
APOHApolipoprotein H. (345 aa)
PDX1Pancreatic and duodenal homeobox 1. (283 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
ARUncharacterized protein. (392 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1558 aa)
BRCA2BRCA2 DNA repair associated. (3419 aa)
RGCCRegulator of cell cycle. (137 aa)
SLURP1Secreted LY6/PLAUR domain containing 1. (103 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (423 aa)
G1QLB3_NOMLEC-C motif chemokine. (138 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (100 aa)
SYNJ2BPSynaptojanin 2 binding protein. (145 aa)
PRLProlactin. (227 aa)
CNMDChondromodulin. (310 aa)
GDF2Growth differentiation factor 2. (429 aa)
TINF2TERF1 interacting nuclear factor 2. (451 aa)
A4GNTAlpha-1,4-N-acetylglucosaminyltransferase. (327 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (203 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
PDCD10Programmed cell death 10. (212 aa)
TBC1D31TBC1 domain family member 31. (1067 aa)
MEN1Menin 1. (614 aa)
OVOL1Ovo like transcriptional repressor 1. (267 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
SFRP2Secreted frizzled related protein 2. (280 aa)
IFT52Intraflagellar transport 52. (396 aa)
PTPRMProtein tyrosine phosphatase receptor type M. (1465 aa)
PHOX2BPaired like homeobox 2B. (314 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
TNMDTenomodulin. (317 aa)
WDR13WD repeat domain 13. (485 aa)
EREGEpiregulin. (169 aa)
MAGED1MAGE family member D1. (823 aa)
NOTCH1Notch receptor 1. (2451 aa)
NLRC3NLR family CARD domain containing 3. (1102 aa)
GDF5Growth differentiation factor 5. (442 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
ISL1ISL LIM homeobox 1. (349 aa)
CEACAM1Uncharacterized protein. (493 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (86 aa)
GATA3GATA binding protein 3. (444 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
FLCNFolliculin. (542 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
STK4Serine/threonine kinase 4. (490 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
RIDAReactive intermediate imine deaminase A homolog. (137 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (487 aa)
ENSNLEP00000033330Uncharacterized protein. (193 aa)
SULF1Sulfatase 1. (812 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
IRF6Interferon regulatory factor 6. (467 aa)
STAT1Signal transducer and activator of transcription. (780 aa)
LIMS2LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (365 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
ENSNLEP00000034659Uncharacterized protein. (407 aa)
WDR77WD repeat domain 77. (347 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
ATP5IF1ATP synthase inhibitory factor subunit 1. (106 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (159 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (361 aa)
ROBO1Roundabout guidance receptor 1. (1651 aa)
AIMP1Aminoacyl tRNA synthetase complex interacting multifunctional protein 1. (321 aa)
EAF2ELL associated factor 2. (263 aa)
INTUInturned planar cell polarity protein. (949 aa)
NF1Neurofibromin 1. (2839 aa)
ENSNLEP00000040898Uncharacterized protein. (411 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (299 aa)
XDHXanthine dehydrogenase. (1271 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (545 aa)
THBS1Thrombospondin 1. (1173 aa)
PAX6Uncharacterized protein. (456 aa)
PTPRKProtein tyrosine phosphatase receptor type K. (1416 aa)
DAB2IPDAB2 interacting protein. (1159 aa)
KLF9Kruppel like factor 9. (244 aa)
TRIM24Tripartite motif containing 24. (1049 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (335 aa)
NR2F2Nuclear receptor subfamily 2 group F member 2. (414 aa)
COL4A3Collagen type IV alpha 3 chain. (1600 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (396 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
DUSP10Dual specificity phosphatase 10. (482 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
NKX2-8NK2 homeobox 8. (229 aa)
IFT172Intraflagellar transport 172. (1703 aa)
IL26Interleukin 26. (171 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (692 aa)
RB1RB transcriptional corepressor 1. (919 aa)
G1QS07_NOMLEUncharacterized protein. (248 aa)
CPB2Carboxypeptidase B2. (423 aa)
MMRN2Multimerin 2. (949 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (912 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (916 aa)
MCCUncharacterized protein. (921 aa)
RAP1GAPRAP1 GTPase activating protein. (696 aa)
MTSS1MTSS I-BAR domain containing 1. (759 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (445 aa)
IFT80Intraflagellar transport 80. (777 aa)
NKX3-1NK3 homeobox 1. (230 aa)
CD109CD109 molecule. (1405 aa)
HPNHepsin; Belongs to the peptidase S1 family. (431 aa)
IFT57Intraflagellar transport 57. (429 aa)
SOX9SRY-box transcription factor 9. (510 aa)
STK3Serine/threonine kinase 3. (519 aa)
KRIT1Uncharacterized protein. (736 aa)
ENGEndoglin. (658 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (366 aa)
CDKN1BUncharacterized protein. (204 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
SOX2SRY-box transcription factor 2. (319 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1105 aa)
CDC73Cell division cycle 73. (531 aa)
VDRVitamin D receptor. (427 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
KRT4Keratin 4; Belongs to the intermediate filament family. (519 aa)
FGFR2Fibroblast growth factor receptor. (820 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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