STRINGSTRING
PDGFB PDGFB LIF LIF CBLB CBLB IFNG IFNG NF2 NF2 NTF3 NTF3 CNOT7 CNOT7 ITGB2 ITGB2 CD300A CD300A UNC119 UNC119 GGNBP2 GGNBP2 IL6ST IL6ST IL31RA IL31RA RIPK2 RIPK2 AGT AGT SH3BP5 SH3BP5 PAK2 PAK2 CADM4 CADM4 NCAPG2 NCAPG2 LYN LYN LRRK1 LRRK1 DGKQ DGKQ NOD2 NOD2 IL24 IL24 ACVR1 ACVR1 IL20 IL20 ALKAL1 ALKAL1 SH2B3 SH2B3 SYK SYK SEMA4D SEMA4D FLT3 FLT3 PARP14 PARP14 PARP9 PARP9 DOK7 DOK7 PRKCZ PRKCZ HCLS1 HCLS1 ZFYVE28 ZFYVE28 PTPN11 PTPN11 TNFRSF18 TNFRSF18 GPRC5A GPRC5A LTK LTK LOC100579700 LOC100579700 LOC100580921 LOC100580921 IL12B IL12B IL12A IL12A GHRL GHRL PTPN22 PTPN22 CD4 CD4 VEGFB VEGFB ENPP2 ENPP2 CD80 CD80 TREM2 TREM2 PTPN6 PTPN6 IL15 IL15 PPP2R5B PPP2R5B KITLG KITLG FBXW7 FBXW7 SFRP2 SFRP2 TDGF1 TDGF1 FGF7 FGF7 LILRA5 LILRA5 CLCF1 CLCF1 HRG HRG ADIPOQ ADIPOQ YES1 YES1 HYAL2 HYAL2 CASS4 CASS4 ERBB4 ERBB4 PRKCD PRKCD CBL CBL LOC100607462 LOC100607462 GATA1 GATA1 EREG EREG BTC BTC PDGFA PDGFA IL9 IL9 KIT KIT ERRFI1 ERRFI1 JAK2 JAK2 STAP1 STAP1 RELN RELN HBEGF HBEGF ANGPT4 ANGPT4 TMEM102 TMEM102 IL2 IL2 IL21 IL21 SPINK1 SPINK1 ZGPAT ZGPAT TGFA TGFA CSF1R CSF1R CD74 CD74 GAS6 GAS6 IL11 IL11 GREM1 GREM1 PLCG2 PLCG2 ISL1 ISL1 EFNA5 EFNA5 HAX1 HAX1 FGFR1OP FGFR1OP BMP6 BMP6 VPS25 VPS25 EPO EPO IBTK IBTK ABL1 ABL1 SFRP1 SFRP1 IL3 IL3 CSF2 CSF2 IL5 IL5 SOCS4 SOCS4 IL4 IL4 THBS4 THBS4 OSBP OSBP CSPG4 CSPG4 ADAM17 ADAM17 TGFB1 TGFB1 CCL5 CCL5 LRP4 LRP4 IFNL1 IFNL1 PTPRJ PTPRJ FGF8 FGF8 PECAM1 PECAM1 NEURL1 NEURL1 LOC100580921-2 LOC100580921-2 TNFSF18 TNFSF18 ALK ALK ERCC6 ERCC6 PIBF1 PIBF1 IL34 IL34 AFAP1L2 AFAP1L2 PTK2B PTK2B RICTOR RICTOR EGF EGF INPP5F INPP5F PRKCE PRKCE ZZEF1 ZZEF1 HPX HPX IL23A IL23A ITGA5 ITGA5 TSG101 TSG101 CD44 CD44 LRP8 LRP8 PTPRC PTPRC SOCS1 SOCS1 G1SB75_NOMLE G1SB75_NOMLE M3Z980_NOMLE M3Z980_NOMLE EHD4 EHD4 ADNP ADNP HGF HGF NRP1 NRP1 PRNP PRNP ENSNLEP00000024736 ENSNLEP00000024736 FGFR3 FGFR3 PDGFD PDGFD LOC100585742 LOC100585742 ENSNLEP00000025390 ENSNLEP00000025390 CNTF CNTF FAM72A FAM72A FBXW9 FBXW9 WNT3A WNT3A EFNA1 EFNA1 APP APP CTF1 CTF1 TSLP TSLP ENSNLEP00000027584 ENSNLEP00000027584 SAMSN1 SAMSN1 ARHGEF2 ARHGEF2 GDNF GDNF FGF10 FGF10 CSF3 CSF3 TNFRSF1A TNFRSF1A PTK6 PTK6 IGF2 IGF2 ENSNLEP00000030727 ENSNLEP00000030727 LOC100601933 LOC100601933 NCK2 NCK2 PSEN1 PSEN1 DLG4 DLG4 GRM5 GRM5 CAV1 CAV1 ITGB3 ITGB3 CD40 CD40 CBLC CBLC MTOR MTOR VEGFA VEGFA ENSNLEP00000034490 ENSNLEP00000034490 LOC100582356 LOC100582356 LOC100605369 LOC100605369 IL6R IL6R BST1 BST1 EGFR EGFR ALKAL2 ALKAL2 PPP2R1A PPP2R1A MLST8 MLST8 SOCS5 SOCS5 ENSNLEP00000037238 ENSNLEP00000037238 RAP2B RAP2B DMTN DMTN IL18 IL18 HDAC2 HDAC2 DOCK3 DOCK3 ENSNLEP00000038711 ENSNLEP00000038711 HSF1 HSF1 LACRT LACRT HTR2A HTR2A ENSNLEP00000039626 ENSNLEP00000039626 SRCIN1 SRCIN1 NEDD9 NEDD9 TNFRSF14 TNFRSF14 EPHA7 EPHA7 PDGFC PDGFC CD81 CD81 AREG AREG PLPP3 PLPP3 ANGPT1 ANGPT1 FYN FYN OSM OSM THY1 THY1 IL7 IL7 PPP2CA PPP2CA ARL2BP ARL2BP CD3E CD3E ENSNLEP00000042160 ENSNLEP00000042160 ENSNLEP00000042424 ENSNLEP00000042424 EPHA4 EPHA4 ABI1 ABI1 CHMP6 CHMP6 GFRA1 GFRA1 DLG3 DLG3 DVL2 DVL2 ENSNLEP00000043688 ENSNLEP00000043688 ADRA1A ADRA1A IL22RA2 IL22RA2 IL23R IL23R PTPN2 PTPN2 GPRC5B GPRC5B CNTN1 CNTN1 IGF1 IGF1 CD36 CD36 NRG1 NRG1 ENSNLEP00000045860 ENSNLEP00000045860 DUSP22 DUSP22 BANK1 BANK1 RACK1 RACK1 GHR GHR IL6 IL6 ERBB3 ERBB3 EPGN EPGN TNK2 TNK2 SRC SRC ACE ACE SH2D1B SH2D1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (233 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
CBLBUncharacterized protein. (817 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
NF2Neurofibromin 2. (595 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (268 aa)
CNOT7CCR4-NOT transcription complex subunit 7. (285 aa)
ITGB2Integrin beta. (762 aa)
CD300ACD300a molecule. (299 aa)
UNC119Unc-119 lipid binding chaperone. (240 aa)
GGNBP2Gametogenetin binding protein 2. (714 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
IL31RAInterleukin 31 receptor A. (745 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
AGTAngiotensinogen; Belongs to the serpin family. (485 aa)
SH3BP5SH3 domain binding protein 5. (455 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
CADM4Cell adhesion molecule 4. (338 aa)
NCAPG2Non-SMC condensin II complex subunit G2. (1135 aa)
LYNTyrosine-protein kinase. (512 aa)
LRRK1Leucine rich repeat kinase 1. (1816 aa)
DGKQDiacylglycerol kinase. (673 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
IL24Interleukin 24. (207 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
IL20Interleukin 20. (176 aa)
ALKAL1ALK and LTK ligand 1. (129 aa)
SH2B3SH2B adaptor protein 3. (567 aa)
SYKTyrosine-protein kinase. (532 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (862 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
PARP14Poly [ADP-ribose] polymerase. (1744 aa)
PARP9Poly(ADP-ribose) polymerase family member 9. (855 aa)
DOK7Docking protein 7. (427 aa)
PRKCZProtein kinase C zeta. (507 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (476 aa)
ZFYVE28Zinc finger FYVE-type containing 28. (854 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
TNFRSF18TNF receptor superfamily member 18. (256 aa)
GPRC5AG protein-coupled receptor class C group 5 member A. (357 aa)
LTKLeukocyte receptor tyrosine kinase. (864 aa)
LOC100579700Uncharacterized protein. (219 aa)
LOC100580921Uncharacterized protein. (216 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (203 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (807 aa)
CD4CD4 molecule. (458 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase 2. (893 aa)
CD80CD80 molecule. (288 aa)
TREM2Ig-like domain-containing protein. (222 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (627 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (424 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
SFRP2Secreted frizzled related protein 2. (280 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (188 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
LILRA5Leukocyte immunoglobulin like receptor A5. (298 aa)
CLCF1Uncharacterized protein. (322 aa)
HRGHistidine rich glycoprotein. (530 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
YES1Tyrosine-protein kinase. (519 aa)
HYAL2Hyaluronidase. (473 aa)
CASS4Cas scaffold protein family member 4. (786 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
CBLCbl proto-oncogene. (905 aa)
LOC100607462Uncharacterized protein. (741 aa)
GATA1GATA binding protein 1. (413 aa)
EREGEpiregulin. (169 aa)
BTCBetacellulin. (178 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
IL9Interleukin 9. (144 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (969 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (462 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
STAP1Signal transducing adaptor family member 1. (295 aa)
RELNReelin. (3460 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
ANGPT4Angiopoietin 4. (480 aa)
TMEM102Mab-21 domain-containing protein. (436 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
SPINK1Serine peptidase inhibitor, Kazal type 1. (79 aa)
ZGPATZinc finger CCCH-type and G-patch domain containing. (520 aa)
TGFATransforming growth factor alpha. (166 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (949 aa)
CD74CD74 molecule. (296 aa)
GAS6Growth arrest specific 6. (679 aa)
IL11Uncharacterized protein. (170 aa)
GREM1CTCK domain-containing protein. (143 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1218 aa)
ISL1ISL LIM homeobox 1. (349 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (275 aa)
FGFR1OPFGFR1 oncogene partner. (399 aa)
BMP6TGF_BETA_2 domain-containing protein. (125 aa)
VPS25Vacuolar protein sorting 25 homolog. (176 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
IBTKInhibitor of Bruton tyrosine kinase. (1353 aa)
ABL1Tyrosine-protein kinase. (1006 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
IL3Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (152 aa)
CSF2Colony stimulating factor 2. (144 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (135 aa)
THBS4Thrombospondin 4. (925 aa)
OSBPOxysterol-binding protein; Belongs to the OSBP family. (807 aa)
CSPG4Chondroitin sulfate proteoglycan 4. (2170 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CCL5C-C motif chemokine. (91 aa)
LRP4LDL receptor related protein 4. (1904 aa)
IFNL1Interferon lambda 1. (200 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1282 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (721 aa)
NEURL1Neuralized E3 ubiquitin protein ligase 1. (574 aa)
LOC100580921-2Growth hormone B1. (217 aa)
TNFSF18Tumor necrosis factor ligand 2A. (199 aa)
ALKUncharacterized protein. (1134 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1492 aa)
PIBF1Progesterone immunomodulatory binding factor 1. (758 aa)
IL34Interleukin 34. (242 aa)
AFAP1L2Actin filament associated protein 1 like 2. (801 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (871 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1709 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
INPP5FInositol polyphosphate-5-phosphatase F. (1132 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
ZZEF1Zinc finger ZZ-type and EF-hand domain containing 1. (2918 aa)
HPXHemopexin. (463 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1038 aa)
TSG101Tumor susceptibility 101. (390 aa)
CD44CD44 molecule (Indian blood group). (742 aa)
LRP8LDL receptor related protein 8. (924 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1304 aa)
SOCS1Suppressor of cytokine signaling 1. (208 aa)
G1SB75_NOMLEUncharacterized protein. (81 aa)
M3Z980_NOMLEARL2_Bind_BART domain-containing protein. (185 aa)
EHD4EH domain containing 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (520 aa)
ADNPActivity dependent neuroprotector homeobox. (1102 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (901 aa)
PRNPMajor prion protein; Belongs to the prion family. (253 aa)
ENSNLEP00000024736Uncharacterized protein. (489 aa)
FGFR3Receptor protein-tyrosine kinase. (583 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
LOC100585742Uncharacterized protein. (222 aa)
ENSNLEP00000025390Tyrosine-protein phosphatase non-receptor type. (391 aa)
CNTFCiliary neurotrophic factor. (200 aa)
FAM72AUncharacterized protein. (148 aa)
FBXW9F-box and WD repeat domain containing 9. (478 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (204 aa)
APPAmyloid beta precursor protein. (757 aa)
CTF1Cardiotrophin 1. (231 aa)
TSLPThymic stromal lymphopoietin. (159 aa)
ENSNLEP00000027584SH2 domain-containing protein. (188 aa)
SAMSN1SAM domain, SH3 domain and nuclear localization signals 1. (441 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1031 aa)
GDNFTGF_BETA_2 domain-containing protein. (169 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
CSF3Colony stimulating factor 3. (207 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
PTK6Tyrosine-protein kinase. (451 aa)
IGF2IlGF domain-containing protein. (180 aa)
ENSNLEP00000030727Uncharacterized protein. (198 aa)
LOC100601933Uncharacterized protein. (203 aa)
NCK2Cytoplasmic protein. (380 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (746 aa)
GRM5Glutamate metabotropic receptor 5. (1210 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (806 aa)
CD40TNFR-Cys domain-containing protein. (219 aa)
CBLCCbl proto-oncogene C. (463 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2578 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (393 aa)
ENSNLEP00000034490Uncharacterized protein. (232 aa)
LOC100582356Uncharacterized protein. (217 aa)
LOC100605369Uncharacterized protein. (571 aa)
IL6RInterleukin 6 receptor. (420 aa)
BST1Bone marrow stromal cell antigen 1. (333 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
ALKAL2ALK and LTK ligand 2. (152 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (588 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
ENSNLEP00000037238Uncharacterized protein. (268 aa)
RAP2BRAP2B, member of RAS oncogene family. (183 aa)
DMTNDematin actin binding protein. (406 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (533 aa)
DOCK3Dedicator of cytokinesis 3; Belongs to the DOCK family. (1987 aa)
ENSNLEP00000038711CFC domain-containing protein. (158 aa)
HSF1HSF_DOMAIN domain-containing protein. (272 aa)
LACRTUncharacterized protein. (102 aa)
HTR2A5-hydroxytryptamine receptor 2A. (471 aa)
ENSNLEP00000039626Uncharacterized protein. (116 aa)
SRCIN1SRC kinase signaling inhibitor 1. (1213 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (838 aa)
TNFRSF14TNFR-Cys domain-containing protein. (231 aa)
EPHA7EPH receptor A7. (972 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
CD81Tetraspanin. (274 aa)
AREGEGF-like domain-containing protein. (274 aa)
PLPP3acidPPc domain-containing protein. (289 aa)
ANGPT1Angiopoietin 1. (498 aa)
FYNTyrosine-protein kinase. (537 aa)
OSMOncostatin M. (252 aa)
THY1Ig-like domain-containing protein. (216 aa)
IL7Interleukin 7. (179 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
ARL2BPADP ribosylation factor like GTPase 2 binding protein. (162 aa)
CD3ECD3e molecule. (198 aa)
ENSNLEP00000042160Tyrosine-protein phosphatase non-receptor type. (386 aa)
ENSNLEP00000042424Tyrosine-protein phosphatase non-receptor type. (405 aa)
EPHA4EPH receptor A4. (967 aa)
ABI1Abl interactor 1. (508 aa)
CHMP6Uncharacterized protein. (192 aa)
GFRA1GDNF family receptor alpha-1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family. (467 aa)
DLG3Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (837 aa)
DVL2Dishevelled segment polarity protein 2. (713 aa)
ENSNLEP00000043688Uncharacterized protein. (273 aa)
ADRA1AAdrenoceptor alpha 1A. (470 aa)
IL22RA2Interleukin 22 receptor subunit alpha 2. (263 aa)
IL23RInterleukin 23 receptor. (629 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (415 aa)
GPRC5BG protein-coupled receptor class C group 5 member B. (344 aa)
CNTN1Contactin 1. (986 aa)
IGF1IlGF domain-containing protein. (196 aa)
CD36CD36 molecule; Belongs to the CD36 family. (433 aa)
NRG1Neuregulin 1. (713 aa)
ENSNLEP00000045860Uncharacterized protein. (64 aa)
DUSP22Dual specificity phosphatase 22; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (205 aa)
BANK1B cell scaffold protein with ankyrin repeats 1. (785 aa)
RACK1WD_REPEATS_REGION domain-containing protein. (320 aa)
GHRGrowth hormone receptor. (645 aa)
IL6Uncharacterized protein. (258 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1343 aa)
EPGNEpithelial mitogen. (154 aa)
TNK2Tyrosine kinase non receptor 2. (1029 aa)
SRCTyrosine-protein kinase. (537 aa)
ACEAngiotensin-converting enzyme. (1202 aa)
SH2D1BSH2 domain containing 1B. (132 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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