(38 nodes) Positive chemotaxis network (Nomascus leucogenys)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

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protein homology

Your Input:
	ALKBH1	AlkB homolog 1, histone H2A dioxygenase. (334 aa)
	VEGFC	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
	HGF	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
	MET	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (901 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	CORO1A	Coronin; Belongs to the WD repeat coronin family. (461 aa)
	PGF	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (225 aa)
	ENSNLEP00000035662	Uncharacterized protein. (69 aa)
	ENSNLEP00000036155	annotation not available (69 aa)
	TSC2	TSC complex subunit 2. (1777 aa)
	ENSNLEP00000040732	Uncharacterized protein. (68 aa)
	ENSNLEP00000045002	Uncharacterized protein. (69 aa)
	PLXNB3	Plexin B3. (1842 aa)
	LRRC1	Leucine rich repeat containing 1. (503 aa)
	ANGPT1	Angiopoietin 1. (498 aa)
	LOC100596700	Uncharacterized protein. (75 aa)
	SCRIB	Scribble planar cell polarity protein. (1449 aa)
	CX3CL1	C-X3-C motif chemokine ligand 1. (397 aa)
	NTF3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (268 aa)
	VEGFB	Vascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
	COLEC10	Collectin subfamily member 10. (277 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	CXCL10	C-X-C motif chemokine. (98 aa)
	VEGFD	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
	SCG2	Secretogranin II. (542 aa)
	SEMA5A	Semaphorin 5A. (1074 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	LGALS3	Galectin. (250 aa)
	CCL5	C-C motif chemokine. (91 aa)
	CCL16	SCY domain-containing protein. (75 aa)
	CCL15	C-C motif chemokine. (113 aa)
	GPNMB	Glycoprotein nmb. (575 aa)
	PTPRJ	Protein tyrosine phosphatase receptor type J. (1282 aa)
	DEFB130B	Uncharacterized protein. (79 aa)
	LOC100604016	DEFSN domain-containing protein. (64 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (233 aa)

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANGPT1	CCL5	ENSNLEP00000040988	ENSNLEP00000017204	Angiopoietin 1.	C-C motif chemokine.	0.454
ANGPT1	FGF10	ENSNLEP00000040988	ENSNLEP00000029066	Angiopoietin 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.458
ANGPT1	FGF7	ENSNLEP00000040988	ENSNLEP00000007476	Angiopoietin 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.491
ANGPT1	HGF	ENSNLEP00000040988	ENSNLEP00000023996	Angiopoietin 1.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.507
ANGPT1	MET	ENSNLEP00000040988	ENSNLEP00000024614	Angiopoietin 1.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.718
ANGPT1	PDGFB	ENSNLEP00000040988	ENSNLEP00000018484	Angiopoietin 1.	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	0.573
ANGPT1	PGF	ENSNLEP00000040988	ENSNLEP00000032743	Angiopoietin 1.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.502
ANGPT1	VEGFB	ENSNLEP00000040988	ENSNLEP00000005905	Angiopoietin 1.	Vascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family.	0.514
ANGPT1	VEGFC	ENSNLEP00000040988	ENSNLEP00000020420	Angiopoietin 1.	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.461
ANGPT1	VEGFD	ENSNLEP00000040988	ENSNLEP00000011402	Angiopoietin 1.	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.	0.451
BMP4	FGF10	ENSNLEP00000015368	ENSNLEP00000029066	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.680
BMP4	FGF7	ENSNLEP00000015368	ENSNLEP00000007476	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.498
BMP4	WNT5A	ENSNLEP00000015368	ENSNLEP00000008828	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.486
CCL15	CCL5	ENSNLEP00000017271	ENSNLEP00000017204	C-C motif chemokine.	C-C motif chemokine.	0.942
CCL15	CXCL10	ENSNLEP00000017271	ENSNLEP00000009846	C-C motif chemokine.	C-X-C motif chemokine.	0.423
CCL16	CCL5	ENSNLEP00000017255	ENSNLEP00000017204	SCY domain-containing protein.	C-C motif chemokine.	0.990
CCL16	CX3CL1	ENSNLEP00000017255	ENSNLEP00000003473	SCY domain-containing protein.	C-X3-C motif chemokine ligand 1.	0.440
CCL16	CXCL10	ENSNLEP00000017255	ENSNLEP00000009846	SCY domain-containing protein.	C-X-C motif chemokine.	0.610
CCL5	ANGPT1	ENSNLEP00000017204	ENSNLEP00000040988	C-C motif chemokine.	Angiopoietin 1.	0.454
CCL5	CCL15	ENSNLEP00000017204	ENSNLEP00000017271	C-C motif chemokine.	C-C motif chemokine.	0.942

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