STRINGSTRING
RBCK1 RBCK1 CTH CTH G1RDL6_NOMLE G1RDL6_NOMLE DHX33 DHX33 RNF25 RNF25 RIPK4 RIPK4 TRAF2 TRAF2 TNFRSF11A TNFRSF11A CLOCK CLOCK TRIM37 TRIM37 MALT1 MALT1 CARD9 CARD9 BTK BTK WNT5A WNT5A G1R620_NOMLE G1R620_NOMLE AGER AGER MAP3K13 MAP3K13 FLOT1 FLOT1 NTS NTS MYD88 MYD88 IRAK2 IRAK2 CAPN3 CAPN3 TRADD TRADD NLRP3 NLRP3 PPIA PPIA MTDH MTDH LAMTOR5 LAMTOR5 TRIM62 TRIM62 IRAK3 IRAK3 TRIM38 TRIM38 CX3CL1 CX3CL1 PRKD2 PRKD2 TRAF5 TRAF5 ITGB2 ITGB2 SPHK1 SPHK1 ADAM8 ADAM8 RIPK2 RIPK2 TRAPPC9 TRAPPC9 NOD2 NOD2 G1QIV4_NOMLE G1QIV4_NOMLE AR AR NPM1 NPM1 PRKCZ PRKCZ TRIM15 TRIM15 IL18 IL18 EDA EDA ENSNLEP00000036988 ENSNLEP00000036988 ERC1 ERC1 RELA RELA RPS6KA4 RPS6KA4 EP300 EP300 TRIM32 TRIM32 CLEC7A CLEC7A TLR6 TLR6 ANKRD42 ANKRD42 ENSNLEP00000034515 ENSNLEP00000034515 ENSNLEP00000032876 ENSNLEP00000032876 CD40 CD40 LTF LTF CAV1 CAV1 ENSNLEP00000031956 ENSNLEP00000031956 EDA2R EDA2R LOC100605411 LOC100605411 ENSNLEP00000029090 ENSNLEP00000029090 PSMA6 PSMA6 ARHGEF2 ARHGEF2 RPS6KA5 RPS6KA5 ENSNLEP00000027802 ENSNLEP00000027802 ENSNLEP00000027432 ENSNLEP00000027432 APP APP CHUK CHUK TNFSF11 TNFSF11 PRKCI PRKCI TLR2 TLR2 DHX9 DHX9 TRAF6 TRAF6 CAT CAT RHEBL1 RHEBL1 TRIM22 TRIM22 TRIM34 TRIM34 TRIM21 TRIM21 TRAF1 TRAF1 TRIM14 TRIM14 CLU CLU PYCARD PYCARD NLRC4 NLRC4 CARD14 CARD14 PLA2G1B PLA2G1B PRKD1 PRKD1 RIPK3 RIPK3 ALK ALK RNF31 RNF31 TNFSF18 TNFSF18 TRIM8 TRIM8 NOD1 NOD1 ROR1 ROR1 IL18RAP IL18RAP IL18R1 IL18R1 IKBKG IKBKG MID2 MID2 TGFB1 TGFB1 MTPN MTPN TICAM1 TICAM1 AIM2 AIM2 TERF2IP TERF2IP IKBKB IKBKB RTKN2 RTKN2 CIB1 CIB1 PRKCQ PRKCQ TRIML2 TRIML2 STAT3 STAT3 TLR3 TLR3 FER FER RIPK1 RIPK1 PLCG2 PLCG2 GREM1 GREM1 CARD11 CARD11 S100A12 S100A12 S100A9 S100A9 CRNN CRNN NTSR1 NTSR1 AMH AMH SLCO3A1 SLCO3A1 ENSNLEP00000039390 ENSNLEP00000039390 ENSNLEP00000039968 ENSNLEP00000039968 ENSNLEP00000040637 ENSNLEP00000040637 BCL10 BCL10 CX3CR1 CX3CR1 TRIM6 TRIM6 EIF2AK2 EIF2AK2 PIDD1 PIDD1 TRIM5 TRIM5 PRKCB PRKCB TIRAP TIRAP TRIM25 TRIM25 CD40LG CD40LG FLOT2 FLOT2 TRIM68 TRIM68 IL1B IL1B TRIM27 TRIM27 CD36 CD36 ENSNLEP00000046123 ENSNLEP00000046123 LOC100584186 LOC100584186 NTRK1 NTRK1 S100A8 S100A8 ENSNLEP00000047262 ENSNLEP00000047262 TRIM13 TRIM13 TNF TNF RPS3 RPS3 IL1RAP IL1RAP DDRGK1 DDRGK1 LOC100584516 LOC100584516
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RBCK1RANBP2-type and C3HC4-type zinc finger containing 1. (509 aa)
CTHCystathionine gamma-lyase. (405 aa)
G1RDL6_NOMLEUncharacterized protein. (279 aa)
DHX33Helicase C-terminal domain-containing protein. (404 aa)
RNF25Ring finger protein 25. (459 aa)
RIPK4Receptor interacting serine/threonine kinase 4. (766 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
TNFRSF11ATNF receptor superfamily member 11a. (595 aa)
CLOCKClock circadian regulator. (846 aa)
TRIM37Tripartite motif containing 37. (928 aa)
MALT1MALT1 paracaspase. (824 aa)
CARD9Caspase recruitment domain family member 9. (536 aa)
BTKTyrosine-protein kinase. (659 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
G1R620_NOMLETIR domain-containing protein. (1031 aa)
AGERAdvanced glycosylation end-product specific receptor. (404 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (966 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
NTSNeurotensin. (170 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (317 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (568 aa)
CAPN3Calpain 3; Belongs to the peptidase C2 family. (837 aa)
TRADDTNFRSF1A associated via death domain. (311 aa)
NLRP3NLR family pyrin domain containing 3. (1020 aa)
PPIAPeptidyl-prolyl cis-trans isomerase A, N-terminally processed; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding; Belongs to the cyclophilin-type PPIase family. PPIase A subfamily. (165 aa)
MTDHMetadherin. (582 aa)
LAMTOR5Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (173 aa)
TRIM62Tripartite motif containing 62. (475 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (596 aa)
TRIM38Tripartite motif containing 38. (465 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (397 aa)
PRKD2Uncharacterized protein. (716 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
ITGB2Integrin beta. (762 aa)
SPHK1DAGKc domain-containing protein. (398 aa)
ADAM8Uncharacterized protein. (678 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
TRAPPC9Trafficking protein particle complex 9. (1190 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
G1QIV4_NOMLETNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (253 aa)
ARUncharacterized protein. (392 aa)
NPM1Nucleophosmin 1. (294 aa)
PRKCZProtein kinase C zeta. (507 aa)
TRIM15Tripartite motif containing 15. (465 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
EDAUncharacterized protein. (145 aa)
ENSNLEP00000036988Nucleoplasmin domain-containing protein. (224 aa)
ERC1ELKS/RAB6-interacting/CAST family member 1. (1104 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
RPS6KA4Ribosomal protein S6 kinase. (743 aa)
EP300E1A binding protein p300. (2306 aa)
TRIM32Tripartite motif containing 32. (653 aa)
CLEC7AC-type lectin domain containing 7A. (247 aa)
TLR6TIR domain-containing protein. (472 aa)
ANKRD42Ankyrin repeat domain 42. (527 aa)
ENSNLEP00000034515Uncharacterized protein. (171 aa)
ENSNLEP00000032876Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (133 aa)
CD40TNFR-Cys domain-containing protein. (219 aa)
LTFUncharacterized protein. (453 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
ENSNLEP00000031956Uncharacterized protein. (104 aa)
EDA2REctodysplasin A2 receptor. (318 aa)
LOC100605411Uncharacterized protein. (733 aa)
ENSNLEP00000029090Uncharacterized protein. (278 aa)
PSMA6Proteasome subunit alpha type. (206 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1031 aa)
RPS6KA5Ribosomal protein S6 kinase. (797 aa)
ENSNLEP00000027802Uncharacterized protein. (223 aa)
ENSNLEP00000027432TNF receptor-associated factor. (488 aa)
APPAmyloid beta precursor protein. (757 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (743 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
TLR2Toll-like receptor. (784 aa)
DHX9DExH-box helicase 9. (1275 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
RHEBL1RHEB like 1. (183 aa)
TRIM22TRIM22. (498 aa)
TRIM34Uncharacterized protein. (483 aa)
TRIM21Tripartite motif containing 21. (475 aa)
TRAF1TNF receptor-associated factor. (416 aa)
TRIM14Tripartite motif containing 14. (387 aa)
CLUClusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (448 aa)
PYCARDPYD and CARD domain containing. (195 aa)
NLRC4NLR family CARD domain containing 4. (862 aa)
CARD14Caspase recruitment domain family member 14. (931 aa)
PLA2G1BPhospholipase A(2). (148 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (506 aa)
ALKUncharacterized protein. (1134 aa)
RNF31Uncharacterized protein. (1072 aa)
TNFSF18Tumor necrosis factor ligand 2A. (199 aa)
TRIM8Tripartite motif containing 8. (551 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
ROR1Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (937 aa)
IL18RAPInterleukin 18 receptor accessory protein. (599 aa)
IL18R1Interleukin 18 receptor 1. (541 aa)
IKBKGNEMO domain-containing protein. (173 aa)
MID2Midline 2. (736 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
MTPNMyotrophin. (118 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (691 aa)
AIM2Absent in melanoma 2. (344 aa)
TERF2IPRap1_C domain-containing protein. (289 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (745 aa)
RTKN2Rhotekin 2. (609 aa)
CIB1Uncharacterized protein. (187 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
TRIML2Tripartite motif family like 2. (438 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1218 aa)
GREM1CTCK domain-containing protein. (143 aa)
CARD11Caspase recruitment domain family member 11. (1154 aa)
S100A12S100 calcium binding protein A12; Belongs to the S-100 family. (91 aa)
S100A9Protein S100; Belongs to the S-100 family. (112 aa)
CRNNCornulin. (495 aa)
NTSR1Neurotensin receptor 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
AMHTGF_BETA_2 domain-containing protein. (341 aa)
SLCO3A1Solute carrier organic anion transporter family member. (566 aa)
ENSNLEP00000039390Protein kinase domain-containing protein. (673 aa)
ENSNLEP00000039968Nucleoplasmin domain-containing protein. (274 aa)
ENSNLEP00000040637Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (166 aa)
BCL10CARD domain-containing protein. (319 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (386 aa)
TRIM6Tripartite motif containing 6. (516 aa)
EIF2AK2Uncharacterized protein. (543 aa)
PIDD1P53-induced death domain protein 1. (883 aa)
TRIM5Tripartite motif-containing protein 5; Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1- UBE2N (als [...] (479 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
TIRAPTIR domain containing adaptor protein. (221 aa)
TRIM25Tripartite motif containing 25. (630 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (472 aa)
TRIM68Tripartite motif containing 68. (485 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
TRIM27Tripartite motif containing 27. (513 aa)
CD36CD36 molecule; Belongs to the CD36 family. (433 aa)
ENSNLEP00000046123Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (136 aa)
LOC100584186KH type-2 domain-containing protein. (260 aa)
NTRK1Tyrosine-protein kinase receptor. (787 aa)
S100A8Protein S100; Belongs to the S-100 family. (93 aa)
ENSNLEP00000047262Uncharacterized protein. (644 aa)
TRIM13Tripartite motif containing 13. (410 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
RPS3Ribosomal_S3_C domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (190 aa)
IL1RAPInterleukin 1 receptor accessory protein. (687 aa)
DDRGK1DDRGK domain containing 1. (314 aa)
LOC100584516Uncharacterized protein. (306 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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