STRINGSTRING
OSBP OSBP RBP4 RBP4 SLC51B SLC51B SMO SMO ANKRD1 ANKRD1 KIF20B KIF20B LEP LEP ANK3 ANK3 FRMD4A FRMD4A ACHE ACHE CIB1 CIB1 CHP2 CHP2 CFTR CFTR TCAF2C TCAF2C BMP6 BMP6 ZC3H12A ZC3H12A IER3IP1 IER3IP1 UCN3 UCN3 ICE1 ICE1 LOC100584360 LOC100584360 JUP JUP ISL1 ISL1 VPS28 VPS28 GSK3A GSK3A GAS6 GAS6 OAZ3 OAZ3 EDEM2 EDEM2 ABLIM3 ABLIM3 ABAT ABAT MYH10 MYH10 ACSL3 ACSL3 HDAC3 HDAC3 NLGN2 NLGN2 NR0B2 NR0B2 WLS WLS APBB3 APBB3 NKX6-1 NKX6-1 G1RCQ7_NOMLE G1RCQ7_NOMLE CEMIP CEMIP BAIAP3 BAIAP3 HRAS HRAS SEC24A SEC24A SAR1B SAR1B IPO5 IPO5 MAVS MAVS SYTL4 SYTL4 C2CD2L C2CD2L VPS11 VPS11 ZPR1 ZPR1 EXPH5 EXPH5 PRKCD PRKCD HYAL2 HYAL2 KCNB1 KCNB1 MTCL1 MTCL1 MYOM1 MYOM1 PPID PPID G1R3I2_NOMLE G1R3I2_NOMLE PTPN23 PTPN23 NNAT NNAT G1R2U7_NOMLE G1R2U7_NOMLE RPH3AL RPH3AL G1QI67_NOMLE G1QI67_NOMLE BSG BSG PSMD9 PSMD9 CLN3 CLN3 VSNL1 VSNL1 KCNN4 KCNN4 SOX4 SOX4 IL1A IL1A XPO4 XPO4 ADAM8 ADAM8 OAZ1 OAZ1 ZIC1 ZIC1 FGA FGA FGB FGB NR1H4 NR1H4 PIK3R2 PIK3R2 FBXW7 FBXW7 CD33 CD33 MYRIP MYRIP NR1H2 NR1H2 PDZK1 PDZK1 ECT2 ECT2 CTDSPL2 CTDSPL2 CEP290 CEP290 TM7SF3 TM7SF3 ANXA13 ANXA13 CDH1 CDH1 TRH TRH TREM2 TREM2 PDCD10 PDCD10 PARD6A PARD6A HMMR HMMR PTPN22 PTPN22 GHRL GHRL CD2AP CD2AP CNST CNST CDK5 CDK5 PPIA PPIA UBR5 UBR5 IFNG IFNG CHP1 CHP1 CSNK2A2 CSNK2A2 TCAF1 TCAF1 PCNT PCNT GLI3 GLI3 SIRT6 SIRT6 HPCA HPCA PCM1 PCM1 GIP GIP TOMM70 TOMM70 AACS AACS GCG GCG ZDHHC2 ZDHHC2 ITGB2 ITGB2 ENSNLEP00000044067 ENSNLEP00000044067 LOC100579439 LOC100579439 ENSNLEP00000043731 ENSNLEP00000043731 RBM22 RBM22 XBP1 XBP1 EDEM1 EDEM1 RIPOR1 RIPOR1 YWHAE YWHAE KIF3A KIF3A RAC2 RAC2 ANO1 ANO1 AKT2 AKT2 FGG FGG SMAD3 SMAD3 B3GAT3 B3GAT3 FYN FYN ERBB2 ERBB2 ARHGEF5 ARHGEF5 HIF1A HIF1A SRC SRC CAMK1 CAMK1 TNF TNF FZD5 FZD5 ITGB1BP1 ITGB1BP1 IRS2 IRS2 RACK1 RACK1 HNF1A HNF1A ENSNLEP00000046123 ENSNLEP00000046123 MAPK8 MAPK8 UBE2J2 UBE2J2 TMEM30B TMEM30B PRR5L PRR5L EZR EZR GPLD1 GPLD1 MFF MFF IGF1 IGF1 LOC100583245 LOC100583245 IL1B IL1B ENSNLEP00000044651 ENSNLEP00000044651 ENSNLEP00000044241 ENSNLEP00000044241 BBC3 BBC3 RUFY3 RUFY3 ENSNLEP00000040637 ENSNLEP00000040637 LOC105739090 LOC105739090 CD81 CD81 SLC30A8 SLC30A8 FIS1 FIS1 HTRA2 HTRA2 CAPN10 CAPN10 ENSNLEP00000039670 ENSNLEP00000039670 ENSNLEP00000039612 ENSNLEP00000039612 UNC13B UNC13B ADCY8 ADCY8 ENSNLEP00000038580 ENSNLEP00000038580 GOLPH3L GOLPH3L BAD BAD TRPM2 TRPM2 MYO18A MYO18A ENSNLEP00000037750 ENSNLEP00000037750 TRPM4 TRPM4 PPARG PPARG ABCG1 ABCG1 ENSNLEP00000036861 ENSNLEP00000036861 BCAS3 BCAS3 PLA2G6 PLA2G6 DNM1L DNM1L TMED10 TMED10 PRKAA1 PRKAA1 BAP1 BAP1 ENSNLEP00000032876 ENSNLEP00000032876 RAB29 RAB29 ENSNLEP00000032399 ENSNLEP00000032399 ZFAND1 ZFAND1 ARF6 ARF6 ATP13A2 ATP13A2 UBL5 UBL5 PIK3R1 PIK3R1 ATP2C1 ATP2C1 DMAP1 DMAP1 RHOU RHOU ENSNLEP00000031088 ENSNLEP00000031088 TRIM28 TRIM28 PSEN1 PSEN1 STOM STOM TOMM7 TOMM7 EXOC1 EXOC1 ADAM9 ADAM9 PCSK1 PCSK1 SORL1 SORL1 TUNAR TUNAR ENSNLEP00000028495 ENSNLEP00000028495 ENSNLEP00000028440 ENSNLEP00000028440 CD38 CD38 TM9SF4 TM9SF4 OAZ2 OAZ2 ENSNLEP00000027513 ENSNLEP00000027513 CREBRF CREBRF PDX1 PDX1 CASR CASR PRKCZ PRKCZ HCLS1 HCLS1 USP36 USP36 C1QTNF12 C1QTNF12 HUWE1 HUWE1 MIEF1 MIEF1 GPR68 GPR68 AKAP5 AKAP5 TLR2 TLR2 UBL5-2 UBL5-2 SFN SFN PTGS2 PTGS2 TPR TPR GLUL GLUL GCK GCK ENSNLEP00000027457 ENSNLEP00000027457 PPP3CB PPP3CB GOLPH3 GOLPH3 ENSNLEP00000027025 ENSNLEP00000027025 C2CD5 C2CD5 FBXW9 FBXW9 GSK3B GSK3B MAPK10 MAPK10 MYO1C MYO1C LEPROT LEPROT PRKACA PRKACA ASPH ASPH PRNP PRNP F2RL1 F2RL1 GPER1 GPER1 MAPK14 MAPK14 BLK BLK PINK1 PINK1 LRRC8A LRRC8A PPARD PPARD RAPGEF3 RAPGEF3 TSG101 TSG101 APBB1 APBB1 ANP32B ANP32B PRKCE PRKCE VEGFC VEGFC BAG3 BAG3 OXCT1 OXCT1 TGFB3 TGFB3 MCU MCU ITGAM ITGAM STX4 STX4 G1S1R3_NOMLE G1S1R3_NOMLE P2RX7 P2RX7 CEP131 CEP131 TCF7L2 TCF7L2 SREBF2 SREBF2 VPS35 VPS35 PLA2G1B PLA2G1B PRKD1 PRKD1 ADORA2A ADORA2A SEC16B SEC16B RNF31 RNF31 PCK2 PCK2 TENM1 TENM1 SRI SRI EFCAB7 EFCAB7 MPC2 MPC2 SLC35D3 SLC35D3 ACSL4 ACSL4 C1QTNF3 C1QTNF3 PLK3 PLK3 TGFB2 TGFB2 EMD EMD FLNA FLNA MIEF2 MIEF2 HPCAL1 HPCAL1 TGFB1 TGFB1 PPM1A PPM1A RFX6 RFX6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
OSBPOxysterol-binding protein; Belongs to the OSBP family. (807 aa)
RBP4Retinol-binding protein; Retinol-binding protein that mediates retinol transport in blood plasma. (201 aa)
SLC51BSolute carrier family 51 beta subunit. (128 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (683 aa)
ANKRD1Ankyrin repeat domain 1. (286 aa)
KIF20BKinesin family member 20B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1822 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
ANK3Ankyrin 3. (4058 aa)
FRMD4AFERM domain containing 4A. (962 aa)
ACHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (617 aa)
CIB1Uncharacterized protein. (187 aa)
CHP2Calcineurin like EF-hand protein 2. (196 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1480 aa)
TCAF2CTRPM8 channel associated factor 2C. (759 aa)
BMP6TGF_BETA_2 domain-containing protein. (125 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (560 aa)
IER3IP1Uncharacterized protein. (82 aa)
UCN3Urocortin 3. (161 aa)
ICE1Interactor of little elongation complex ELL subunit 1. (2220 aa)
LOC100584360Uncharacterized protein. (532 aa)
JUPJunction plakoglobin. (730 aa)
ISL1ISL LIM homeobox 1. (349 aa)
VPS28VPS28 N-terminal domain-containing protein; Belongs to the VPS28 family. (197 aa)
GSK3AGlycogen synthase kinase 3 alpha. (439 aa)
GAS6Growth arrest specific 6. (679 aa)
OAZ3Uncharacterized protein. (235 aa)
EDEM2alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (577 aa)
ABLIM3Actin binding LIM protein family member 3. (699 aa)
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (516 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1976 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (720 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
NLGN2Neuroligin 2. (768 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (257 aa)
WLSWnt ligand secretion mediator. (542 aa)
APBB3Uncharacterized protein. (583 aa)
NKX6-1NK6 homeobox 1. (368 aa)
G1RCQ7_NOMLEUncharacterized protein. (237 aa)
CEMIPCell migration inducing hyaluronidase 1. (1357 aa)
BAIAP3BAI1 associated protein 3. (1094 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
SEC24ASEC24 homolog A, COPII coat complex component. (1093 aa)
SAR1BSecretion associated Ras related GTPase 1B; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
IPO5Importin 5. (1067 aa)
MAVSUncharacterized protein. (491 aa)
SYTL4Synaptotagmin like 4. (672 aa)
C2CD2LC2CD2 like. (716 aa)
VPS11Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (931 aa)
ZPR1ZPR1 zinc finger. (459 aa)
EXPH5Exophilin 5. (1981 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
HYAL2Hyaluronidase. (473 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
MTCL1Microtubule crosslinking factor 1. (1675 aa)
MYOM1Myomesin 1. (1685 aa)
PPIDPeptidylprolyl isomerase D. (370 aa)
G1R3I2_NOMLEUncharacterized protein; Belongs to the heat shock protein 70 family. (516 aa)
PTPN23Protein tyrosine phosphatase non-receptor type 23. (1619 aa)
NNATNeuronatin. (81 aa)
G1R2U7_NOMLEUncharacterized protein. (5430 aa)
RPH3ALRabphilin 3A like (without C2 domains). (314 aa)
G1QI67_NOMLEERAP1_C domain-containing protein. (442 aa)
BSGUncharacterized protein. (345 aa)
PSMD9PDZ domain-containing protein. (222 aa)
CLN3Battenin. (384 aa)
VSNL1Visinin like 1. (191 aa)
KCNN4CaMBD domain-containing protein. (702 aa)
SOX4Transcription factor SOX. (459 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (247 aa)
XPO4Exportin 4. (1151 aa)
ADAM8Uncharacterized protein. (678 aa)
OAZ1Uncharacterized protein. (228 aa)
ZIC1Zic family member 1. (451 aa)
FGAFibrinogen alpha chain. (863 aa)
FGBFibrinogen beta chain. (491 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
PIK3R2Uncharacterized protein. (727 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
CD33CD33 molecule. (364 aa)
MYRIPMyosin VIIA and Rab interacting protein. (796 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (461 aa)
PDZK1PDZ domain containing 1. (519 aa)
ECT2Epithelial cell transforming 2. (914 aa)
CTDSPL2CTD small phosphatase like 2. (466 aa)
CEP290Centrosomal protein 290. (2446 aa)
TM7SF3Transmembrane 7 superfamily member 3. (570 aa)
ANXA13Annexin. (357 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (883 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (242 aa)
TREM2Ig-like domain-containing protein. (222 aa)
PDCD10Programmed cell death 10. (212 aa)
PARD6APar-6 family cell polarity regulator alpha. (346 aa)
HMMRHyaluronan mediated motility receptor. (725 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (807 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
CD2APCD2 associated protein. (639 aa)
CNSTConsortin, connexin sorting protein. (725 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (320 aa)
PPIAPeptidyl-prolyl cis-trans isomerase A, N-terminally processed; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding; Belongs to the cyclophilin-type PPIase family. PPIase A subfamily. (165 aa)
UBR5Ubiquitin protein ligase E3 component n-recognin 5. (2778 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
CHP1Calcineurin like EF-hand protein 1. (195 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (320 aa)
TCAF1TRPM8 channel associated factor 1. (921 aa)
PCNTPericentrin. (3278 aa)
GLI3GLI family zinc finger 3. (1502 aa)
SIRT6Deacetylase sirtuin-type domain-containing protein. (215 aa)
HPCAHippocalcin. (193 aa)
PCM1Pericentriolar material 1. (2032 aa)
GIPGastric inhibitory polypeptide. (153 aa)
TOMM70Translocase of outer mitochondrial membrane 70. (608 aa)
AACSAcetoacetyl-CoA synthetase. (672 aa)
GCGGlucagon. (180 aa)
ZDHHC2Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (367 aa)
ITGB2Integrin beta. (762 aa)
ENSNLEP00000044067Uncharacterized protein. (108 aa)
LOC100579439Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family. (319 aa)
ENSNLEP00000043731Uncharacterized protein. (166 aa)
RBM22Uncharacterized protein. (613 aa)
XBP1BZIP domain-containing protein. (376 aa)
EDEM1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (630 aa)
RIPOR1RHO family interacting cell polarization regulator 1. (1208 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
KIF3AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (724 aa)
RAC2Rac family small GTPase 2. (192 aa)
ANO1Anoctamin. (912 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (398 aa)
FGGFibrinogen gamma chain. (463 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
B3GAT3Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family. (321 aa)
FYNTyrosine-protein kinase. (537 aa)
ERBB2Receptor protein-tyrosine kinase. (1247 aa)
ARHGEF5DH domain-containing protein. (302 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
SRCTyrosine-protein kinase. (537 aa)
CAMK1Protein kinase domain-containing protein. (324 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
IRS2Insulin receptor substrate 2. (1344 aa)
RACK1WD_REPEATS_REGION domain-containing protein. (320 aa)
HNF1AUncharacterized protein. (562 aa)
ENSNLEP00000046123Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (136 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
UBE2J2Ubiquitin conjugating enzyme E2 J2. (275 aa)
TMEM30BCell cycle control protein; Belongs to the CDC50/LEM3 family. (350 aa)
PRR5LProline rich 5 like. (368 aa)
EZREzrin. (586 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (840 aa)
MFFMitochondrial fission factor. (342 aa)
IGF1IlGF domain-containing protein. (196 aa)
LOC10058324514_3_3 domain-containing protein; Belongs to the 14-3-3 family. (224 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
ENSNLEP00000044651EF-hand domain-containing protein. (184 aa)
ENSNLEP00000044241PHB domain-containing protein. (282 aa)
BBC3BCL2 binding component 3. (237 aa)
RUFY3RUN and FYVE domain containing 3. (594 aa)
ENSNLEP00000040637Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (166 aa)
LOC105739090Uncharacterized protein. (158 aa)
CD81Tetraspanin. (274 aa)
SLC30A8Solute carrier family 30 member 8. (369 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
HTRA2HtrA serine peptidase 2. (458 aa)
CAPN10Calpain 10; Belongs to the peptidase C2 family. (672 aa)
ENSNLEP00000039670Gln-synt_C domain-containing protein; Belongs to the glutamine synthetase family. (334 aa)
ENSNLEP00000039612Uncharacterized protein. (517 aa)
UNC13BUncharacterized protein. (4218 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1255 aa)
ENSNLEP00000038580GOLD domain-containing protein; Belongs to the EMP24/GP25L family. (100 aa)
GOLPH3LGolgi phosphoprotein 3 like. (285 aa)
BADUncharacterized protein. (82 aa)
TRPM2LSDAT_euk domain-containing protein. (1224 aa)
MYO18AMyosin XVIIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2019 aa)
ENSNLEP00000037750Gln-synt_C domain-containing protein; Belongs to the glutamine synthetase family. (341 aa)
TRPM4Uncharacterized protein. (1010 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
ABCG1ATP binding cassette subfamily G member 1. (591 aa)
ENSNLEP00000036861Uncharacterized protein. (119 aa)
BCAS3BCAS3 microtubule associated cell migration factor. (950 aa)
PLA2G6Phospholipase A2 group VI. (805 aa)
DNM1LDynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (699 aa)
TMED10Transmembrane p24 trafficking protein 10. (219 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
BAP1Ubiquitin carboxyl-terminal hydrolase. (695 aa)
ENSNLEP00000032876Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (133 aa)
RAB29RAB29, member RAS oncogene family. (203 aa)
ENSNLEP00000032399Uncharacterized protein. (628 aa)
ZFAND1Zinc finger AN1-type containing 1. (268 aa)
ARF6Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (175 aa)
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1012 aa)
UBL5annotation not available (73 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
ATP2C1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (973 aa)
DMAP1DNA methyltransferase 1 associated protein 1. (467 aa)
RHOURas homolog family member U. (258 aa)
ENSNLEP00000031088Protein kinase domain-containing protein. (557 aa)
TRIM28Tripartite motif containing 28. (808 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
STOMPHB domain-containing protein. (288 aa)
TOMM7Uncharacterized protein. (126 aa)
EXOC1Exocyst complex component 1. (901 aa)
ADAM9ADAM metallopeptidase domain 9. (819 aa)
PCSK1Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (744 aa)
SORL1Sortilin related receptor 1. (2174 aa)
TUNARTCL1 upstream neural differentiation-associated RNA. (48 aa)
ENSNLEP00000028495Uncharacterized protein. (253 aa)
ENSNLEP00000028440Uncharacterized protein. (95 aa)
CD38CD38 molecule. (300 aa)
TM9SF4Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (642 aa)
OAZ2Uncharacterized protein. (189 aa)
ENSNLEP00000027513Uncharacterized protein. (154 aa)
CREBRFUncharacterized protein. (336 aa)
PDX1Pancreatic and duodenal homeobox 1. (283 aa)
CASRCalcium sensing receptor. (1088 aa)
PRKCZProtein kinase C zeta. (507 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (476 aa)
USP36Ubiquitin specific peptidase 36; Belongs to the peptidase C19 family. (1116 aa)
C1QTNF12C1q domain-containing protein. (213 aa)
HUWE1HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1. (4378 aa)
MIEF1Mitochondrial elongation factor 1. (502 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (375 aa)
AKAP5A-kinase anchoring protein 5. (427 aa)
TLR2Toll-like receptor. (784 aa)
UBL5-2Ubiquitin-like domain-containing protein. (73 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
TPRTranslocated promoter region, nuclear basket protein. (2354 aa)
GLULGlutamine synthetase. (373 aa)
GCKPhosphotransferase. (427 aa)
ENSNLEP00000027457Gln-synt_C domain-containing protein; Belongs to the glutamine synthetase family. (329 aa)
PPP3CBSerine/threonine-protein phosphatase. (408 aa)
GOLPH3Golgi phosphoprotein 3. (298 aa)
ENSNLEP00000027025PPM-type phosphatase domain-containing protein. (340 aa)
C2CD5C2 calcium dependent domain containing 5. (1042 aa)
FBXW9F-box and WD repeat domain containing 9. (478 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
MYO1CMyosin IC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1023 aa)
LEPROTLeptin receptor overlapping transcript. (139 aa)
PRKACAProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (294 aa)
ASPHAspartate beta-hydroxylase. (762 aa)
PRNPMajor prion protein; Belongs to the prion family. (253 aa)
F2RL1F2R like trypsin receptor 1. (397 aa)
GPER1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (377 aa)
MAPK14Mitogen-activated protein kinase. (321 aa)
BLKTyrosine-protein kinase. (505 aa)
PINK1Protein kinase domain-containing protein. (563 aa)
LRRC8ALeucine rich repeat containing 8 VRAC subunit A. (810 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (853 aa)
TSG101Tumor susceptibility 101. (390 aa)
APBB1Uncharacterized protein. (574 aa)
ANP32BAcidic nuclear phosphoprotein 32 family member B. (251 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
BAG3BCL2 associated athanogene 3. (574 aa)
OXCT1Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (476 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
MCUMitochondrial calcium uniporter. (352 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (992 aa)
STX4Syntaxin 4; Belongs to the syntaxin family. (297 aa)
G1S1R3_NOMLEPeptidase_M1 domain-containing protein. (161 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
CEP131Centrosomal protein 131. (951 aa)
TCF7L2HMG box domain-containing protein. (534 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1067 aa)
VPS35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (790 aa)
PLA2G1BPhospholipase A(2). (148 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
SEC16BProtein transport protein sec16; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. (940 aa)
RNF31Uncharacterized protein. (1072 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (575 aa)
TENM1Teneurin transmembrane protein 1. (2731 aa)
SRISorcin. (221 aa)
EFCAB7EF-hand calcium binding domain 7. (629 aa)
MPC2Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (127 aa)
SLC35D3Solute carrier family 35 member D3. (416 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (711 aa)
C1QTNF3C1q domain-containing protein. (319 aa)
PLK3Polo like kinase 3. (641 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
EMDEmerin. (254 aa)
FLNAFilamin A. (2626 aa)
MIEF2Mitochondrial elongation factor 2. (464 aa)
HPCAL1Hippocalcin like 1. (193 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa)
RFX6Regulatory factor X6. (928 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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