STRINGSTRING
DDIT3 DDIT3 TRPV1 TRPV1 PRKCE PRKCE LETM1 LETM1 G1QH14_NOMLE G1QH14_NOMLE HTT HTT NOS1 NOS1 FKBP1B FKBP1B MCOLN1 MCOLN1 CXCR3 CXCR3 LYN LYN JPH1 JPH1 LOC100595279 LOC100595279 JSRP1 JSRP1 LCK LCK CACNA1C CACNA1C CX3CL1 CX3CL1 AKAP6 AKAP6 DIAPH1 DIAPH1 ITPR1 ITPR1 CAPN3 CAPN3 BAX BAX CCL21 CCL21 TRPC1 TRPC1 CASQ2 CASQ2 HRC HRC PTPN6 PTPN6 ANK2 ANK2 PTK2B PTK2B P2RX7 P2RX7 PRKD1 PRKD1 HTR2B HTR2B LOC100598445 LOC100598445 LOC100606903 LOC100606903 CHERP CHERP LOC100604100 LOC100604100 CCR7 CCR7 SLC8B1 SLC8B1 ENSNLEP00000044067 ENSNLEP00000044067 RYR2 RYR2 CLIC2 CLIC2 THY1 THY1 ENSNLEP00000041070 ENSNLEP00000041070 BBC3 BBC3 P2RY6 P2RY6 LOC100593010 LOC100593010 ITPR3 ITPR3 CAMK2D CAMK2D HTR2A HTR2A LACRT LACRT DRD1 DRD1 TRPM2 TRPM2 RYR1 RYR1 ANXA6 ANXA6 MCOLN3 MCOLN3 ENSNLEP00000035652 ENSNLEP00000035652 FASLG FASLG JPH4 JPH4 SRI SRI SELENON SELENON HTR2C HTR2C CHD7 CHD7 ITPR2 ITPR2 DMD DMD ITGB3 ITGB3 CORO1A CORO1A TMEM38A TMEM38A XCR1 XCR1 PLCG1 PLCG1 JPH2 JPH2 TPCN2 TPCN2 SNCA SNCA F2 F2 FLNA FLNA SLC8A1 SLC8A1 LIME1 LIME1 CALM1 CALM1 ENSNLEP00000029433 ENSNLEP00000029433 ENSNLEP00000028440 ENSNLEP00000028440 PDE4D PDE4D PLN PLN NPSR1 NPSR1 GP1BB GP1BB LOC100607679 LOC100607679 PRKACA PRKACA ASPH ASPH TRDN TRDN GPER1 GPER1 BDKRB1 BDKRB1 PTPRC PTPRC GP1BA GP1BA TMEM38B TMEM38B TGFB1 TGFB1 CASQ1 CASQ1 ATG5 ATG5 F2R F2R ABL1 ABL1 APLNR APLNR IBTK IBTK UBASH3B UBASH3B RASA3 RASA3 CXCL11 CXCL11 CXCL9 CXCL9 CXCL10 CXCL10 LHCGR LHCGR CEMIP CEMIP LOC100592336 LOC100592336 PKD2 PKD2 NTSR1 NTSR1 MCOLN2 MCOLN2 DHRS7C DHRS7C PLCG2 PLCG2 RYR3 RYR3 HAP1 HAP1 CD19 CD19 TRPA1 TRPA1 ERO1A ERO1A GSTO1 GSTO1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (850 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
LETM1Leucine zipper and EF-hand containing transmembrane protein 1. (739 aa)
G1QH14_NOMLEUncharacterized protein. (500 aa)
HTTHuntingtin. (3048 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1425 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
MCOLN1Mucolipin 1. (580 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (368 aa)
LYNTyrosine-protein kinase. (512 aa)
JPH1Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (661 aa)
LOC100595279Uncharacterized protein. (212 aa)
JSRP1Junctional sarcoplasmic reticulum protein 1. (334 aa)
LCKLCK proto-oncogene, Src family tyrosine kinase. (448 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1985 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (397 aa)
AKAP6A-kinase anchoring protein 6. (2238 aa)
DIAPH1Diaphanous related formin 1. (1214 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2755 aa)
CAPN3Calpain 3; Belongs to the peptidase C2 family. (837 aa)
BAXUncharacterized protein. (194 aa)
CCL21C-C motif chemokine ligand 21. (134 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (881 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (373 aa)
HRCHistidine rich calcium binding protein. (696 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (627 aa)
ANK2Ankyrin 2. (3957 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (871 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa)
HTR2BG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (398 aa)
LOC100598445EF-hand domain-containing protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (426 aa)
LOC100606903Uncharacterized protein; Belongs to the GST superfamily. (236 aa)
CHERPCalcium homeostasis endoplasmic reticulum protein. (916 aa)
LOC100604100Uncharacterized protein. (123 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
SLC8B1Na_Ca_ex domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (143 aa)
ENSNLEP00000044067Uncharacterized protein. (108 aa)
RYR2Ryanodine receptor 2. (4825 aa)
CLIC2Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (243 aa)
THY1Ig-like domain-containing protein. (216 aa)
ENSNLEP00000041070Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (703 aa)
BBC3BCL2 binding component 3. (237 aa)
P2RY6Pyrimidinergic receptor P2Y6. (328 aa)
LOC100593010Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (459 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2755 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (533 aa)
HTR2A5-hydroxytryptamine receptor 2A. (471 aa)
LACRTUncharacterized protein. (102 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
TRPM2LSDAT_euk domain-containing protein. (1224 aa)
RYR1Ryanodine receptor 1. (4415 aa)
ANXA6Annexin. (673 aa)
MCOLN3Mucolipin 3. (553 aa)
ENSNLEP00000035652Uncharacterized protein; Belongs to the calmodulin family. (123 aa)
FASLGTumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family. (280 aa)
JPH4Junctophilin 4. (613 aa)
SRISorcin. (221 aa)
SELENONUncharacterized protein. (66 aa)
HTR2C5-hydroxytryptamine receptor 2C. (458 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2997 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2727 aa)
DMDDystrophin. (3685 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (806 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
TMEM38ATransmembrane protein 38A. (299 aa)
XCR1X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (333 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1182 aa)
JPH2Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (680 aa)
TPCN2Uncharacterized protein. (735 aa)
SNCAAlpha-synuclein; Belongs to the synuclein family. (140 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (613 aa)
FLNAFilamin A. (2626 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (972 aa)
LIME1Uncharacterized protein. (210 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (150 aa)
ENSNLEP00000029433Uncharacterized protein. (691 aa)
ENSNLEP00000028440Uncharacterized protein. (95 aa)
PDE4DPhosphodiesterase. (748 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
NPSR1Neuropeptide S receptor 1. (391 aa)
GP1BBGlycoprotein Ib platelet subunit beta. (206 aa)
LOC100607679SCY domain-containing protein. (98 aa)
PRKACAProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (294 aa)
ASPHAspartate beta-hydroxylase. (762 aa)
TRDNTriadin. (728 aa)
GPER1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (377 aa)
BDKRB1G_PROTEIN_RECEP_F1_2 domain-containing protein. (284 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1304 aa)
GP1BAGlycoprotein Ib platelet subunit alpha. (679 aa)
TMEM38BTransmembrane protein 38B. (291 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (121 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
ABL1Tyrosine-protein kinase. (1006 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
IBTKInhibitor of Bruton tyrosine kinase. (1353 aa)
UBASH3BUbiquitin associated and SH3 domain containing B. (599 aa)
RASA3RAS p21 protein activator 3. (816 aa)
CXCL11C-X-C motif chemokine. (94 aa)
CXCL9C-X-C motif chemokine. (125 aa)
CXCL10C-X-C motif chemokine. (98 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (701 aa)
CEMIPCell migration inducing hyaluronidase 1. (1357 aa)
LOC100592336PH_3 domain-containing protein. (247 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (921 aa)
NTSR1Neurotensin receptor 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
MCOLN2Mucolipin 2. (566 aa)
DHRS7CDehydrogenase/reductase 7C; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (285 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1218 aa)
RYR3Ryanodine receptor 3. (4794 aa)
HAP1Huntingtin associated protein 1. (624 aa)
CD19CD19 molecule. (558 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1094 aa)
ERO1AEndoplasmic reticulum oxidoreductase 1 alpha. (468 aa)
GSTO1Glutathione S-transferase omega 1. (241 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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