STRINGSTRING
PSEN1 PSEN1 FAM162A FAM162A NR4A2 NR4A2 G1QS07_NOMLE G1QS07_NOMLE RB1 RB1 TFAP2B TFAP2B NAE1 NAE1 CDK5 CDK5 GAPDH GAPDH TNFRSF21 TNFRSF21 BAX BAX CNTFR CNTFR KRAS KRAS APAF1 APAF1 RHOA RHOA ATM ATM CASP9 CASP9 BOK BOK TMTC4 TMTC4 LIG4 LIG4 HRAS HRAS NLRP1 NLRP1 BCL2L1 BCL2L1 DRAXIN DRAXIN FADD FADD DNAJC5B DNAJC5B CASP3 CASP3 FAS FAS SNCB SNCB NES NES BARHL1 BARHL1 POLB POLB NCSTN NCSTN SNCA SNCA MAX MAX TRPC5 TRPC5 RAPSN RAPSN FGF8 FGF8 AIFM1 AIFM1 NEFL NEFL FAIM2 FAIM2 ADNP ADNP ENSNLEP00000024681 ENSNLEP00000024681 SYNGAP1 SYNGAP1 THRB THRB APP APP DLX1 DLX1 ATN1 ATN1 GRIK2 GRIK2 CORO1A CORO1A SIAH1 SIAH1 BNIP3 BNIP3 TP63 TP63 SPG11 SPG11 ATF2 ATF2 DNAJC5 DNAJC5 CLN8 CLN8 AGTR2 AGTR2 BCL2 BCL2 ENSNLEP00000036737 ENSNLEP00000036737 ENSNLEP00000036861 ENSNLEP00000036861 BID BID CIT CIT STAMBP STAMBP PIGT PIGT OXR1 OXR1 HIPK2 HIPK2 EPHA7 EPHA7 NF1 NF1 NFATC4 NFATC4 ANGPT1 ANGPT1 PPARGC1A PPARGC1A AKT2 AKT2 SCN2A SCN2A ROCK1 ROCK1 ENSNLEP00000044511 ENSNLEP00000044511 CASP7 CASP7 SLC1A1 SLC1A1 NTRK1 NTRK1 ERBB3 ERBB3 AXL AXL ADARB1 ADARB1 HIF1A HIF1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
FAM162AFamily with sequence similarity 162 member A. (154 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
G1QS07_NOMLEUncharacterized protein. (248 aa)
RB1RB transcriptional corepressor 1. (919 aa)
TFAP2BTranscription factor AP-2 beta. (460 aa)
NAE1NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (532 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (320 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (335 aa)
TNFRSF21TNF receptor superfamily member 21. (654 aa)
BAXUncharacterized protein. (194 aa)
CNTFRCiliary neurotrophic factor receptor. (372 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
RHOARas homolog family member A. (193 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3055 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (426 aa)
BOKBCL2 family apoptosis regulator BOK. (211 aa)
TMTC4Transmembrane O-mannosyltransferase targeting cadherins 4. (760 aa)
LIG4DNA ligase. (911 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
NLRP1NLR family pyrin domain containing 1. (1470 aa)
BCL2L1BCL2 like 1. (217 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (349 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
DNAJC5BDnaJ heat shock protein family (Hsp40) member C5 beta. (199 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
FASFas cell surface death receptor. (335 aa)
SNCBBeta-synuclein; Belongs to the synuclein family. (135 aa)
NESIF rod domain-containing protein; Belongs to the intermediate filament family. (1230 aa)
BARHL1BarH like homeobox 1. (327 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
NCSTNNicastrin. (702 aa)
SNCAAlpha-synuclein; Belongs to the synuclein family. (140 aa)
MAXMYC associated factor X. (160 aa)
TRPC5Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (974 aa)
RAPSNReceptor associated protein of the synapse. (412 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
AIFM1Apoptosis inducing factor mitochondria associated 1. (613 aa)
NEFLNeurofilament light; Belongs to the intermediate filament family. (542 aa)
FAIM2Uncharacterized protein; Belongs to the BI1 family. (254 aa)
ADNPActivity dependent neuroprotector homeobox. (1102 aa)
ENSNLEP00000024681AA_TRNA_LIGASE_II_ALA domain-containing protein. (415 aa)
SYNGAP1Ras-GAP domain-containing protein. (1226 aa)
THRBUncharacterized protein. (476 aa)
APPAmyloid beta precursor protein. (757 aa)
DLX1Distal-less homeobox 1. (255 aa)
ATN1Atrophin 1. (1228 aa)
GRIK2Glutamate ionotropic receptor kainate type subunit 2. (908 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
SIAH1E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (313 aa)
BNIP3Uncharacterized protein. (231 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
SPG11SPG11 vesicle trafficking associated, spatacsin. (2443 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
DNAJC5DnaJ heat shock protein family (Hsp40) member C5. (198 aa)
CLN8CLN8 transmembrane ER and ERGIC protein. (286 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
ENSNLEP00000036737Uncharacterized protein. (160 aa)
ENSNLEP00000036861Uncharacterized protein. (119 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (214 aa)
CITCitron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2048 aa)
STAMBPSTAM binding protein. (424 aa)
PIGTPhosphatidylinositol glycan anchor biosynthesis class T. (588 aa)
OXR1Oxidation resistance 1. (875 aa)
HIPK2Homeodomain interacting protein kinase 2. (1198 aa)
EPHA7EPH receptor A7. (972 aa)
NF1Neurofibromin 1. (2839 aa)
NFATC4Nuclear factor of activated T cells 4. (844 aa)
ANGPT1Angiopoietin 1. (498 aa)
PPARGC1APPARG coactivator 1 alpha. (801 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (398 aa)
SCN2ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1939 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1359 aa)
ENSNLEP00000044511POU domain protein. (242 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (387 aa)
SLC1A1Amino acid transporter. (457 aa)
NTRK1Tyrosine-protein kinase receptor. (787 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1343 aa)
AXLReceptor protein-tyrosine kinase. (860 aa)
ADARB1Adenosine deaminase RNA specific B1. (741 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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