(91 nodes) Regulation of stress fiber assembly network (Nomascus leucogenys)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	BAG4	BCL2 associated athanogene 4. (456 aa)
	ABL1	Tyrosine-protein kinase. (1006 aa)
	SFRP1	Secreted frizzled related protein 1. (314 aa)
	TSC1	TSC complex subunit 1. (1164 aa)
	S100A10	S100 calcium binding protein A10; Belongs to the S-100 family. (97 aa)
	CORO2B	Coronin; Belongs to the WD repeat coronin family. (413 aa)
	BBS4	Bardet-Biedl syndrome 4. (518 aa)
	MKKS	McKusick-Kaufman syndrome. (570 aa)
	CCN2	Cellular communication network factor 2. (349 aa)
	AMOT	Angiomotin. (1088 aa)
	ARHGEF10	Rho guanine nucleotide exchange factor 10. (1354 aa)
	MYOC	Myocilin. (526 aa)
	SORBS3	Sorbin and SH3 domain containing 3. (676 aa)
	RAC1	Rac family small GTPase 1. (187 aa)
	PTGER4	Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (490 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	SYNPO2L	Synaptopodin 2 like. (978 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	GPR65	G protein-coupled receptor 65; Belongs to the G-protein coupled receptor 1 family. (337 aa)
	SERPINF2	Serpin family F member 2; Belongs to the serpin family. (468 aa)
	LIMCH1	LIM and calponin homology domains 1. (1467 aa)
	LPAR1	Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
	RAPGEF3	Rap guanine nucleotide exchange factor 3. (853 aa)
	TACSTD2	Tumor associated calcium signal transducer 2. (323 aa)
	CDC42	Cell division cycle 42. (191 aa)
	TTC8	Tetratricopeptide repeat domain 8. (515 aa)
	CCDC88A	Coiled-coil domain containing 88A. (1871 aa)
	PFN1-2	Profilin; Belongs to the profilin family. (128 aa)
	CLASP2	Uncharacterized protein. (1515 aa)
	STMN1	Stathmin; Belongs to the stathmin family. (172 aa)
	ITGB1BP1	Integrin subunit beta 1 binding protein 1. (200 aa)
	RHOC	Ras homolog family member C. (209 aa)
	PXN	Uncharacterized protein. (1078 aa)
	ARHGAP6	Rho GTPase activating protein 6. (973 aa)
	TMEFF2	Transmembrane protein with EGF like and two follistatin like domains 2. (374 aa)
	ARHGEF5	DH domain-containing protein. (302 aa)
	ARHGEF15	Rho guanine nucleotide exchange factor 15. (842 aa)
	ACTG1	Actin gamma 1. (378 aa)
	LOC100581805	Uncharacterized protein. (1144 aa)
	F11R	F11 receptor. (299 aa)
	MET	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (901 aa)
	CLASP1	Cytoplasmic linker associated protein 1. (1538 aa)
	RHPN2	Hr1 domain-containing protein. (128 aa)
	TACR1	Tachykinin receptor 1. (406 aa)
	ENSNLEP00000027935	Uncharacterized protein. (181 aa)
	ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1. (1384 aa)
	PHLDB2	Pleckstrin homology like domain family B member 2. (1253 aa)
	EVL	Enah/Vasp-like. (458 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
	ENSNLEP00000032399	Uncharacterized protein. (628 aa)
	ENSNLEP00000032709	Profilin; Belongs to the profilin family. (120 aa)
	TPM1	Uncharacterized protein; Belongs to the tropomyosin family. (326 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2578 aa)
	DLC1	DLC1 Rho GTPase activating protein. (1528 aa)
	ENSNLEP00000034935	Uncharacterized protein. (310 aa)
	ROCK2	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
	FERMT2	Fermitin family member 2. (693 aa)
	CARMIL1	Capping protein regulator and myosin 1 linker 1. (1310 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (764 aa)
	FRMD7	FERM domain containing 7. (713 aa)
	PAK2	Non-specific serine/threonine protein kinase. (524 aa)
	RHPN1	Uncharacterized protein. (472 aa)
	RGCC	Regulator of cell cycle. (137 aa)
	INPP5K	Inositol polyphosphate-5-phosphatase K. (372 aa)
	ALMS1	ALMS1 centrosome and basal body associated protein. (4052 aa)
	PPM1F	Protein phosphatase, Mg2+/Mn2+ dependent 1F. (454 aa)
	SYNPO	Uncharacterized protein. (195 aa)
	ENSNLEP00000042609	Uncharacterized protein. (168 aa)
	TJP1	Tight junction protein 1; Belongs to the MAGUK family. (1754 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
	LIMK1	Uncharacterized protein. (614 aa)
	LOC100603674	Uncharacterized protein. (371 aa)
	LOC100593615	TPR_REGION domain-containing protein. (160 aa)
	TESK1	Testis associated actin remodelling kinase 1. (620 aa)
	ENSNLEP00000036737	Uncharacterized protein. (160 aa)
	S1PR1	Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
	PAK1	Non-specific serine/threonine protein kinase. (545 aa)
	ARHGAP28	Rho-GAP domain-containing protein. (729 aa)
	RHOA	Ras homolog family member A. (193 aa)
	CGNL1	Cingulin like 1. (1302 aa)
	SDC4	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (198 aa)
	PIK3R2	Uncharacterized protein. (727 aa)
	NF2	Neurofibromin 2. (595 aa)
	EPHA1	EPH receptor A1. (975 aa)
	WAS	WASP actin nucleation promoting factor. (502 aa)
	PPM1E	Protein phosphatase, Mg2+/Mn2+ dependent 1E. (758 aa)
	ASAP3	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3. (903 aa)
	SLC9A1	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (809 aa)
	WASF2	WH2 domain-containing protein. (401 aa)

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	CDC42	ENSNLEP00000015256	ENSNLEP00000040816	Tyrosine-protein kinase.	Cell division cycle 42.	0.680
ABL1	ENSNLEP00000027935	ENSNLEP00000015256	ENSNLEP00000027935	Tyrosine-protein kinase.	Uncharacterized protein.	0.450
ABL1	ENSNLEP00000042609	ENSNLEP00000015256	ENSNLEP00000042609	Tyrosine-protein kinase.	Uncharacterized protein.	0.450
ABL1	EVL	ENSNLEP00000015256	ENSNLEP00000028966	Tyrosine-protein kinase.	Enah/Vasp-like.	0.463
ABL1	LOC100603674	ENSNLEP00000015256	ENSNLEP00000035875	Tyrosine-protein kinase.	Uncharacterized protein.	0.501
ABL1	PIK3R1	ENSNLEP00000015256	ENSNLEP00000031935	Tyrosine-protein kinase.	Phosphoinositide-3-kinase regulatory subunit 1.	0.779
ABL1	PXN	ENSNLEP00000015256	ENSNLEP00000047920	Tyrosine-protein kinase.	Uncharacterized protein.	0.593
ABL1	RAC1	ENSNLEP00000015256	ENSNLEP00000019034	Tyrosine-protein kinase.	Rac family small GTPase 1.	0.450
ABL1	RHOA	ENSNLEP00000015256	ENSNLEP00000008325	Tyrosine-protein kinase.	Ras homolog family member A.	0.449
ABL1	SORBS3	ENSNLEP00000015256	ENSNLEP00000018997	Tyrosine-protein kinase.	Sorbin and SH3 domain containing 3.	0.416
ABL1	WASF2	ENSNLEP00000015256	ENSNLEP00000011724	Tyrosine-protein kinase.	WH2 domain-containing protein.	0.501
ACTG1	CDC42	ENSNLEP00000023255	ENSNLEP00000040816	Actin gamma 1.	Cell division cycle 42.	0.943
ACTG1	ENSNLEP00000032709	ENSNLEP00000023255	ENSNLEP00000032709	Actin gamma 1.	Profilin; Belongs to the profilin family.	0.569
ACTG1	PFN1-2	ENSNLEP00000023255	ENSNLEP00000046571	Actin gamma 1.	Profilin; Belongs to the profilin family.	0.955
ACTG1	PXN	ENSNLEP00000023255	ENSNLEP00000047920	Actin gamma 1.	Uncharacterized protein.	0.933
ACTG1	RHOA	ENSNLEP00000023255	ENSNLEP00000008325	Actin gamma 1.	Ras homolog family member A.	0.928
ACTG1	SYNPO	ENSNLEP00000023255	ENSNLEP00000043555	Actin gamma 1.	Uncharacterized protein.	0.925
ACTG1	TJP1	ENSNLEP00000023255	ENSNLEP00000042198	Actin gamma 1.	Tight junction protein 1; Belongs to the MAGUK family.	0.924
ACTG1	TPM1	ENSNLEP00000023255	ENSNLEP00000033303	Actin gamma 1.	Uncharacterized protein; Belongs to the tropomyosin family.	0.420
ACTG1	WAS	ENSNLEP00000023255	ENSNLEP00000009578	Actin gamma 1.	WASP actin nucleation promoting factor.	0.945

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