STRINGSTRING
RAPGEF3 RAPGEF3 CITED1 CITED1 ENSNLEP00000024944 ENSNLEP00000024944 SDC1 SDC1 ENSNLEP00000025620 ENSNLEP00000025620 HCN1 HCN1 ENSNLEP00000026090 ENSNLEP00000026090 ENSNLEP00000027205 ENSNLEP00000027205 CPS1 CPS1 ENSNLEP00000028114 ENSNLEP00000028114 PDE4D PDE4D SLC8A1 SLC8A1 RAP1B RAP1B SREBF1 SREBF1 KDM1A KDM1A ENSNLEP00000032480 ENSNLEP00000032480 THBD THBD FDX1 FDX1 ENSNLEP00000034094 ENSNLEP00000034094 ITPR2 ITPR2 STAT1 STAT1 ENSNLEP00000035372 ENSNLEP00000035372 ENSNLEP00000036455 ENSNLEP00000036455 PDE2A PDE2A EEF2K EEF2K ENSNLEP00000037553 ENSNLEP00000037553 DMTN DMTN BIRC2 BIRC2 ENSNLEP00000038911 ENSNLEP00000038911 ENSNLEP00000039230 ENSNLEP00000039230 AREG AREG ENSNLEP00000041025 ENSNLEP00000041025 ENSNLEP00000041886 ENSNLEP00000041886 ENSNLEP00000042382 ENSNLEP00000042382 ENSNLEP00000042529 ENSNLEP00000042529 ENSNLEP00000042687 ENSNLEP00000042687 CNGA3 CNGA3 LOC105740713 LOC105740713 EZR EZR WNT10B WNT10B WT1 WT1 HMGCS2 HMGCS2 FOS FOS ENSNLEP00000048155 ENSNLEP00000048155 ENSNLEP00000048405 ENSNLEP00000048405 PFKFB1 PFKFB1 DUOX1 DUOX1 AQP1 AQP1 RPLP0 RPLP0 BSG BSG HCN2 HCN2 INPP5K INPP5K DGKQ DGKQ ZFP36L1 ZFP36L1 PENK PENK FOSB FOSB AANAT AANAT AKAP6 AKAP6 RAP1A RAP1A DUOX2 DUOX2 SLC5A5 SLC5A5 FOSL1 FOSL1 RAPGEF2 RAPGEF2 SLC26A6 SLC26A6 ADIPOQ ADIPOQ GATA6 GATA6 IGFBP5 IGFBP5 OXT OXT GATA1 GATA1 SLC26A3 SLC26A3 PIK3CG PIK3CG COL1A1 COL1A1 PKD2 PKD2 PTAFR PTAFR PER1 PER1 PPARGC1B PPARGC1B NDUFS4 NDUFS4 SLC6A3 SLC6A3 AQP9 AQP9 SRD5A1 SRD5A1 CFTR CFTR AQP8 AQP8 HCN3 HCN3 PAX4 PAX4 CARM1 CARM1 BCKDHB BCKDHB ASS1 ASS1 CRHBP CRHBP RAPGEF1 RAPGEF1 HCN4 HCN4 AKAP7 AKAP7 AKAP9 AKAP9 STC1 STC1 PTK2B PTK2B CYP1B1 CYP1B1 MMP19 MMP19 GPD1 GPD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAPGEF3Rap guanine nucleotide exchange factor 3. (853 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
ENSNLEP00000024944Uncharacterized protein. (179 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (310 aa)
ENSNLEP00000025620Uncharacterized protein. (154 aa)
HCN1Cyclic nucleotide-binding domain-containing protein. (628 aa)
ENSNLEP000000260903-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (258 aa)
ENSNLEP00000027205Uncharacterized protein. (353 aa)
CPS1Carbamoyl-phosphate synthase 1. (1506 aa)
ENSNLEP00000028114Uncharacterized protein. (405 aa)
PDE4DPhosphodiesterase. (748 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (972 aa)
RAP1BRAP1B, member of RAS oncogene family. (165 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1147 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (759 aa)
ENSNLEP0000003248060S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (293 aa)
THBDThrombomodulin. (568 aa)
FDX1Ferredoxin 1. (184 aa)
ENSNLEP00000034094Uncharacterized protein. (313 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2727 aa)
STAT1Signal transducer and activator of transcription. (780 aa)
ENSNLEP00000035372TGF_BETA_2 domain-containing protein. (392 aa)
ENSNLEP00000036455Uncharacterized protein. (127 aa)
PDE2APhosphodiesterase. (950 aa)
EEF2KEukaryotic elongation factor 2 kinase. (725 aa)
ENSNLEP00000037553Uncharacterized protein. (100 aa)
DMTNDematin actin binding protein. (406 aa)
BIRC2Baculoviral IAP repeat containing 2. (615 aa)
ENSNLEP00000038911RL10P_insert domain-containing protein. (305 aa)
ENSNLEP00000039230RL10P_insert domain-containing protein. (265 aa)
AREGEGF-like domain-containing protein. (274 aa)
ENSNLEP00000041025Uncharacterized protein. (381 aa)
ENSNLEP00000041886Ion_trans domain-containing protein; Belongs to the potassium channel family. (359 aa)
ENSNLEP00000042382Uncharacterized protein. (425 aa)
ENSNLEP00000042529CARM1 domain-containing protein. (165 aa)
ENSNLEP00000042687Uncharacterized protein. (245 aa)
CNGA3Cyclic nucleotide gated channel subunit alpha 3. (698 aa)
LOC1057407132Fe-2S ferredoxin-type domain-containing protein. (172 aa)
EZREzrin. (586 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (335 aa)
WT1WT1 transcription factor. (302 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
ENSNLEP00000048155Uncharacterized protein. (265 aa)
ENSNLEP00000048405Uncharacterized protein. (167 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (471 aa)
DUOX1Dual oxidase 1. (1505 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
RPLP060S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (317 aa)
BSGUncharacterized protein. (345 aa)
HCN2Cyclic nucleotide-binding domain-containing protein. (510 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (372 aa)
DGKQDiacylglycerol kinase. (673 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
PENKProenkephalin. (267 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
AANATN-acetyltransferase domain-containing protein. (207 aa)
AKAP6A-kinase anchoring protein 6. (2238 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
DUOX2Dual oxidase 2. (1548 aa)
SLC5A5Uncharacterized protein; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (577 aa)
FOSL1BZIP domain-containing protein. (271 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1642 aa)
SLC26A6Solute carrier family 26 member 6. (759 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
GATA6Uncharacterized protein. (452 aa)
IGFBP5Insulin like growth factor binding protein 5. (272 aa)
OXTOxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (124 aa)
GATA1GATA binding protein 1. (413 aa)
SLC26A3Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (759 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
COL1A1Collagen type I alpha 1 chain. (1386 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (921 aa)
PTAFRPlatelet activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (342 aa)
PER1Period circadian regulator 1. (1268 aa)
PPARGC1BPPARG coactivator 1 beta. (1013 aa)
NDUFS4NADH:ubiquinone oxidoreductase subunit S4. (175 aa)
SLC6A3Solute carrier family 6 member 3. (552 aa)
AQP9Aquaporin 9; Belongs to the MIP/aquaporin (TC 1.A.8) family. (295 aa)
SRD5A13-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (259 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1480 aa)
AQP8Aquaporin 8; Belongs to the MIP/aquaporin (TC 1.A.8) family. (246 aa)
HCN3Hyperpolarization activated cyclic nucleotide gated potassium channel 3. (729 aa)
PAX4Paired box 4. (352 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (563 aa)
BCKDHBBranched chain keto acid dehydrogenase E1 subunit beta. (391 aa)
ASS1Uncharacterized protein. (412 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1110 aa)
HCN4Cyclic nucleotide-binding domain-containing protein. (754 aa)
AKAP7A-kinase anchoring protein 7. (348 aa)
AKAP9A-kinase anchoring protein 9. (3896 aa)
STC1Stanniocalcin 1. (247 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (871 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
MMP19Matrix metallopeptidase 19. (491 aa)
GPD1Glycerol-3-phosphate dehydrogenase [NAD(+)]. (349 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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