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TTC7A TTC7A BDH2 BDH2 GLRX3 GLRX3 FTMT FTMT HPX HPX EPAS1 EPAS1 ATP6V1G1 ATP6V1G1 SCARA5 SCARA5 FBXL5 FBXL5 SLC25A37 SLC25A37 GDF2 GDF2 STEAP2 STEAP2 STEAP1 STEAP1 STEAP4 STEAP4 TMPRSS6 TMPRSS6 FLVCR1 FLVCR1 ATP6AP1 ATP6AP1 NEO1 NEO1 SLC39A8 SLC39A8 TFR2 TFR2 SMAD4 SMAD4 BMP6 BMP6 BTBD9 BTBD9 ERFE ERFE CCDC115 CCDC115 STEAP3 STEAP3 NUBP1 NUBP1 NDFIP1 NDFIP1 ABCB6 ABCB6 IREB2 IREB2 SLC11A1 SLC11A1 HEPHL1 HEPHL1 HYAL2 HYAL2 ISCU ISCU SLC40A1 SLC40A1 HJV HJV MYC MYC CYBRD1 CYBRD1 EPB42 EPB42 ATP6V1A ATP6V1A RHAG RHAG TF TF SOD1 SOD1 ACO1 ACO1 FTH1 FTH1 CP CP SLC46A1 SLC46A1 ATP6V0A2 ATP6V0A2 MELTF MELTF EIF2AK1 EIF2AK1 ABCB7 ABCB7 HEPH HEPH GLRX5 GLRX5 ENSNLEP00000048874 ENSNLEP00000048874 HIF1A HIF1A ENSNLEP00000048409 ENSNLEP00000048409 ENSNLEP00000047885 ENSNLEP00000047885 ENSNLEP00000047262 ENSNLEP00000047262 SLC25A28 SLC25A28 SLC22A17 SLC22A17 HMOX1 HMOX1 FTL FTL ENSNLEP00000043300 ENSNLEP00000043300 ATP6V0D1 ATP6V0D1 PICALM PICALM LOC101179148 LOC101179148 HMOX2 HMOX2 ENSNLEP00000037971 ENSNLEP00000037971 ENSNLEP00000037793 ENSNLEP00000037793 ENSNLEP00000036509 ENSNLEP00000036509 EGLN1 EGLN1 ENSNLEP00000035899 ENSNLEP00000035899 ENSNLEP00000035804 ENSNLEP00000035804 SLC39A14 SLC39A14 NCOA4 NCOA4 ENSNLEP00000033854 ENSNLEP00000033854 ENSNLEP00000033588 ENSNLEP00000033588 LOC100603451 LOC100603451 ENSNLEP00000032785 ENSNLEP00000032785 LTF LTF BOLA2B BOLA2B ENSNLEP00000032219 ENSNLEP00000032219 ATP13A2 ATP13A2 LCN2 LCN2 LOC100605411 LOC100605411 FXN FXN HAMP HAMP HFE HFE BOLA3 BOLA3 SLC11A2 SLC11A2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TTC7AUncharacterized protein. (762 aa)
BDH23-hydroxybutyrate dehydrogenase 2. (245 aa)
GLRX3Uncharacterized protein. (335 aa)
FTMTFerritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (242 aa)
HPXHemopexin. (463 aa)
EPAS1Endothelial PAS domain protein 1. (869 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
SCARA5Scavenger receptor class A member 5; Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non- transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the de [...] (484 aa)
FBXL5F-box and leucine rich repeat protein 5. (691 aa)
SLC25A37Solute carrier family 25 member 37; Belongs to the mitochondrial carrier (TC 2.A.29) family. (339 aa)
GDF2Growth differentiation factor 2. (429 aa)
STEAP2STEAP2 metalloreductase. (490 aa)
STEAP1Ferric oxidoreductase domain-containing protein. (339 aa)
STEAP4STEAP4 metalloreductase. (459 aa)
TMPRSS6Transmembrane serine protease 6; Belongs to the peptidase S1 family. (806 aa)
FLVCR1Feline leukemia virus subgroup C cellular receptor 1. (555 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (468 aa)
NEO1Neogenin 1. (1461 aa)
SLC39A8Solute carrier family 39 member 8. (444 aa)
TFR2Transferrin receptor 2. (698 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
BMP6TGF_BETA_2 domain-containing protein. (125 aa)
BTBD9BTB domain containing 9. (612 aa)
ERFEErythroferrone. (353 aa)
CCDC115Uncharacterized protein. (193 aa)
STEAP3STEAP3 metalloreductase. (498 aa)
NUBP1Cytosolic Fe-S cluster assembly factor NUBP1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. (320 aa)
NDFIP1Nedd4 family interacting protein 1. (200 aa)
ABCB6ATP binding cassette subfamily B member 6 (Langereis blood group). (843 aa)
IREB2Iron responsive element binding protein 2; Belongs to the aconitase/IPM isomerase family. (964 aa)
SLC11A1Solute carrier family 11 member 1. (550 aa)
HEPHL1Hephaestin like 1; Belongs to the multicopper oxidase family. (1153 aa)
HYAL2Hyaluronidase. (473 aa)
ISCUIron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. (167 aa)
SLC40A1Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (573 aa)
HJVHemojuvelin BMP co-receptor. (427 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
CYBRD1Cytochrome b reductase 1. (286 aa)
EPB42Erythrocyte membrane protein band 4.2. (691 aa)
ATP6V1AATPase H+ transporting V1 subunit A. (617 aa)
RHAGRh associated glycoprotein; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. (428 aa)
TFTransferrin; Belongs to the transferrin family. (698 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
ACO1Aconitase 1; Belongs to the aconitase/IPM isomerase family. (889 aa)
FTH1Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (183 aa)
CPCeruloplasmin; Belongs to the multicopper oxidase family. (1049 aa)
SLC46A1Solute carrier family 46 member 1. (441 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (856 aa)
MELTFMelanotransferrin; Belongs to the transferrin family. (737 aa)
EIF2AK1Eukaryotic translation initiation factor 2 alpha kinase 1. (614 aa)
ABCB7ATP binding cassette subfamily B member 7. (677 aa)
HEPHHephaestin; Belongs to the multicopper oxidase family. (1210 aa)
GLRX5Glutaredoxin 5. (157 aa)
ENSNLEP00000048874Uncharacterized protein. (178 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
ENSNLEP00000048409Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (183 aa)
ENSNLEP00000047885Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (180 aa)
ENSNLEP00000047262Uncharacterized protein. (644 aa)
SLC25A28Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (267 aa)
SLC22A17Solute carrier family 22 member 17. (579 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
FTLFerritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (184 aa)
ENSNLEP00000043300Uncharacterized protein. (598 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (387 aa)
PICALMPhosphatidylinositol binding clathrin assembly protein. (669 aa)
LOC101179148Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (183 aa)
HMOX2Heme oxygenase 2. (370 aa)
ENSNLEP00000037971Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (145 aa)
ENSNLEP00000037793Uncharacterized protein. (122 aa)
ENSNLEP00000036509Uncharacterized protein. (545 aa)
EGLN1Egl-9 family hypoxia inducible factor 1. (416 aa)
ENSNLEP00000035899Uncharacterized protein. (321 aa)
ENSNLEP00000035804Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (92 aa)
SLC39A14Solute carrier family 39 member 14. (490 aa)
NCOA4Nuclear receptor coactivator 4. (651 aa)
ENSNLEP00000033854Uncharacterized protein. (95 aa)
ENSNLEP00000033588Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (178 aa)
LOC100603451Cytochrome b561 domain-containing protein. (320 aa)
ENSNLEP00000032785Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (165 aa)
LTFUncharacterized protein. (453 aa)
BOLA2BUncharacterized protein; Belongs to the BolA/IbaG family. (152 aa)
ENSNLEP00000032219V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (87 aa)
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1012 aa)
LCN2Lipocalin 2; Belongs to the calycin superfamily. Lipocalin family. (191 aa)
LOC100605411Uncharacterized protein. (733 aa)
FXNUncharacterized protein. (196 aa)
HAMPHepcidin antimicrobial peptide. (89 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (345 aa)
BOLA3BolA family member 3; Belongs to the BolA/IbaG family. (107 aa)
SLC11A2Solute carrier family 11 member 2. (568 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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