STRINGSTRING
AXIN1 AXIN1 G1QIV4_NOMLE G1QIV4_NOMLE EDN1 EDN1 FOXO1 FOXO1 TCF7L1 TCF7L1 LATS2 LATS2 DISC1 DISC1 SIAH2 SIAH2 LRP6 LRP6 RYK RYK RECK RECK WNT2B WNT2B EXT1 EXT1 WNT3 WNT3 WNT9B WNT9B G1QYG1_NOMLE G1QYG1_NOMLE CDH3 CDH3 EDNRA EDNRA SOST SOST CTNNB1 CTNNB1 SFRP2 SFRP2 SCYL2 SCYL2 PPP1CA PPP1CA LRP5 LRP5 PYGO1 PYGO1 WNT5A WNT5A HESX1 HESX1 BCL9L BCL9L WNT4 WNT4 WNT6 WNT6 WNT10A WNT10A ISL1 ISL1 JUP JUP PYGO2 PYGO2 WNT2 WNT2 WNT16 WNT16 GATA3 GATA3 DKK1 DKK1 PTEN PTEN SFRP1 SFRP1 FGF9 FGF9 WNT7B WNT7B WNT9A WNT9A RSPO3 RSPO3 G1RVW8_NOMLE G1RVW8_NOMLE WNT8B WNT8B CBY1 CBY1 TCF7L2 TCF7L2 SOSTDC1 SOSTDC1 EDNRB EDNRB FZD3 FZD3 WNT11 WNT11 LGR4 LGR4 WNT1 WNT1 LRRK2 LRRK2 FZD9 FZD9 FZD10 FZD10 DVL3 DVL3 SDC1 SDC1 GSK3B GSK3B WNT3A WNT3A STK3 STK3 SOX9 SOX9 STK4 STK4 LRP5L LRP5L KLF4 KLF4 ENSNLEP00000030555 ENSNLEP00000030555 FZD7 FZD7 SIAH1 SIAH1 YAP1 YAP1 CAV1 CAV1 ENSNLEP00000032476 ENSNLEP00000032476 ENSNLEP00000032543 ENSNLEP00000032543 LEF1 LEF1 FZD4 FZD4 WNT8A WNT8A EDA EDA ENSNLEP00000040092 ENSNLEP00000040092 PLPP3 PLPP3 BCL9 BCL9 DVL1 DVL1 DIXDC1 DIXDC1 CTDNEP1 CTDNEP1 DVL2 DVL2 FZD2 FZD2 FOXD1 FOXD1 WNT10B WNT10B FZD5 FZD5 TCF7 TCF7 RARG RARG SFRP4 SFRP4 ENSNLEP00000048056 ENSNLEP00000048056 DACT3 DACT3 RSPO2 RSPO2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AXIN1Axin 1. (837 aa)
G1QIV4_NOMLETNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (253 aa)
EDN1Endothelin 1. (211 aa)
FOXO1Forkhead box O1. (652 aa)
TCF7L1Transcription factor 7 like 1. (517 aa)
LATS2Non-specific serine/threonine protein kinase. (1084 aa)
DISC1Uncharacterized protein. (202 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (324 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
RYKReceptor like tyrosine kinase. (525 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (971 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (745 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
G1QYG1_NOMLEProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (323 aa)
CDH3Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (829 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
SOSTSclerostin. (213 aa)
CTNNB1Catenin beta 1. (781 aa)
SFRP2Secreted frizzled related protein 2. (280 aa)
SCYL2SCY1 like pseudokinase 2. (933 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
LRP5LDL receptor related protein 5. (1510 aa)
PYGO1Pygopus family PHD finger 1. (419 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
HESX1HESX homeobox 1. (185 aa)
BCL9LBCL9 like. (1338 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (207 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
ISL1ISL LIM homeobox 1. (349 aa)
JUPJunction plakoglobin. (730 aa)
PYGO2Pygopus family PHD finger 2. (357 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
GATA3GATA binding protein 3. (444 aa)
DKK1Dickkopf-like protein 1. (266 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
RSPO3R-spondin 3. (292 aa)
G1RVW8_NOMLEUncharacterized protein. (281 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
CBY1Chibby family member 1, beta catenin antagonist. (161 aa)
TCF7L2HMG box domain-containing protein. (534 aa)
SOSTDC1Sclerostin domain containing 1. (230 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (532 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (929 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
DVL3Dishevelled segment polarity protein 3. (673 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (310 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
STK3Serine/threonine kinase 3. (519 aa)
SOX9SRY-box transcription factor 9. (510 aa)
STK4Serine/threonine kinase 4. (490 aa)
LRP5LUncharacterized protein. (150 aa)
KLF4Uncharacterized protein. (145 aa)
ENSNLEP00000030555Protein kinase domain-containing protein. (200 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
SIAH1E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (313 aa)
YAP1Uncharacterized protein. (418 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
ENSNLEP00000032476FCP1 homology domain-containing protein. (231 aa)
ENSNLEP00000032543Uncharacterized protein. (168 aa)
LEF1Lymphoid enhancer binding factor 1. (386 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
EDAUncharacterized protein. (145 aa)
ENSNLEP00000040092Protein kinase domain-containing protein. (281 aa)
PLPP3acidPPc domain-containing protein. (289 aa)
BCL9BCL9 transcription coactivator. (1426 aa)
DVL1Dishevelled segment polarity protein 1. (667 aa)
DIXDC1DIX domain containing 1. (684 aa)
CTDNEP1FCP1 homology domain-containing protein. (111 aa)
DVL2Dishevelled segment polarity protein 2. (713 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (543 aa)
FOXD1Uncharacterized protein. (241 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (335 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
TCF7HMG box domain-containing protein. (486 aa)
RARGRetinoic acid receptor gamma. (441 aa)
SFRP4Secreted frizzled related protein 4. (369 aa)
ENSNLEP00000048056Uncharacterized protein. (115 aa)
DACT3Uncharacterized protein. (181 aa)
RSPO2R-spondin 2. (250 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
Server load: low (30%) [HD]