STRINGSTRING
BMPR2 BMPR2 TBX3 TBX3 NOG NOG NRP2 NRP2 FZD2 FZD2 SLIT2 SLIT2 SMAD7 SMAD7 SMAD6 SMAD6 TGFBR1 TGFBR1 MKS1 MKS1 ROBO1 ROBO1 SAV1 SAV1 EGLN1 EGLN1 HEY1 HEY1 ENSNLEP00000034753 ENSNLEP00000034753 CHD7 CHD7 ROBO2 ROBO2 BMPR1A BMPR1A ENG ENG NRP1 NRP1 PARVA PARVA FGFR2 FGFR2 WNT11 WNT11 DNAH11 DNAH11 HAND1 HAND1 GATA4 GATA4 CITED2 CITED2 FGF8 FGF8 SEMA3C SEMA3C JAG1 JAG1 PROX1 PROX1 TGFB2 TGFB2 HEY2 HEY2 BMP4 BMP4 SMO SMO APLNR APLNR HEYL HEYL SMAD4 SMAD4 ISL1 ISL1 TGFBR3 TGFBR3 CCN1 CCN1 DHRS3 DHRS3 NOTCH1 NOTCH1 WNT5A WNT5A BMP7 BMP7 GATA6 GATA6 NOTCH2 NOTCH2 SLIT3 SLIT3 LRP2 LRP2 TGFBR2 TGFBR2 NOS3 NOS3 ZFPM2 ZFPM2 RBM15 RBM15 BMP5 BMP5 SOX4 SOX4 TBX20 TBX20 G1QJR7_NOMLE G1QJR7_NOMLE ACVR1 ACVR1 ZFPM1 ZFPM1 NKX2-5 NKX2-5 TBX2 TBX2 TBX5 TBX5 NSD2 NSD2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
TBX3T-box transcription factor 3. (743 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (930 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (543 aa)
SLIT2Slit guidance ligand 2. (1389 aa)
SMAD7Mothers against decapentaplegic homolog. (376 aa)
SMAD6Mothers against decapentaplegic homolog. (465 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
MKS1MKS transition zone complex subunit 1. (546 aa)
ROBO1Roundabout guidance receptor 1. (1651 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
EGLN1Egl-9 family hypoxia inducible factor 1. (416 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (308 aa)
ENSNLEP00000034753Uncharacterized protein. (428 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2997 aa)
ROBO2Roundabout guidance receptor 2. (1199 aa)
BMPR1ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
ENGEndoglin. (658 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (901 aa)
PARVAParvin alpha. (345 aa)
FGFR2Fibroblast growth factor receptor. (820 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
DNAH11Dynein axonemal heavy chain 11. (4498 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
GATA4GATA binding protein 4. (443 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (751 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1157 aa)
PROX1Prospero homeobox 1. (737 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (683 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (279 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ISL1ISL LIM homeobox 1. (349 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
CCN1Cellular communication network factor 1. (317 aa)
DHRS3Dehydrogenase/reductase 3. (258 aa)
NOTCH1Notch receptor 1. (2451 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
BMP7Bone morphogenetic protein 7. (430 aa)
GATA6Uncharacterized protein. (452 aa)
NOTCH2Notch receptor 2. (2444 aa)
SLIT3Slit guidance ligand 3. (1385 aa)
LRP2LDL receptor related protein 2. (4624 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1128 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1151 aa)
RBM15RNA binding motif protein 15. (977 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
SOX4Transcription factor SOX. (459 aa)
TBX20T-box transcription factor 20. (447 aa)
G1QJR7_NOMLEUncharacterized protein. (420 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ZFPM1Zinc finger protein, FOG family member 1. (897 aa)
NKX2-5NK2 homeobox 5. (317 aa)
TBX2T-box transcription factor 2. (647 aa)
TBX5T-box transcription factor 5. (508 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1361 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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