STRINGSTRING
TP63 TP63 EGFR EGFR LUZP1 LUZP1 FGF10 FGF10 FGFR2 FGFR2 SOSTDC1 SOSTDC1 NODAL NODAL BMP4 BMP4 CECR2 CECR2 BMP7 BMP7 BMP5 BMP5 GDF7 GDF7 AR AR HIF1A HIF1A RDH10 RDH10 ENSNLEP00000045603 ENSNLEP00000045603 HOXD13 HOXD13 NOG NOG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
LUZP1Leucine zipper protein 1. (1076 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGFR2Fibroblast growth factor receptor. (820 aa)
SOSTDC1Sclerostin domain containing 1. (230 aa)
NODALNodal growth differentiation factor. (347 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
CECR2CECR2 histone acetyl-lysine reader. (1441 aa)
BMP7Bone morphogenetic protein 7. (430 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
GDF7Growth differentiation factor 7. (450 aa)
ARUncharacterized protein. (392 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
ENSNLEP00000045603Uncharacterized protein. (252 aa)
HOXD13Homeobox D13. (306 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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