STRINGSTRING
LOC100605369 LOC100605369 EGFR EGFR PPP1R9B PPP1R9B GAREM1 GAREM1 ENSNLEP00000038711 ENSNLEP00000038711 LOC100593010 LOC100593010 PTPN12 PTPN12 EEF1A1 EEF1A1 ENSNLEP00000043688 ENSNLEP00000043688 ERBB4 ERBB4 ZPR1 ZPR1 VIL1 VIL1 ERRFI1 ERRFI1 COL1A1 COL1A1 LOC100592336 LOC100592336 SYAP1 SYAP1 ID1 ID1 PDE8A PDE8A STAT5B STAT5B IQGAP1 IQGAP1 BAG4 BAG4 SNAI2 SNAI2 DAB2IP DAB2IP KNSTRN KNSTRN DUSP22 DUSP22 ERBB2 ERBB2 ZFP36L1 ZFP36L1 GAREM2 GAREM2 TDGF1 TDGF1 PLCG1 PLCG1 MCM7 MCM7 PTPN11 PTPN11 INPP5K INPP5K MED1 MED1 NCL NCL ZFP36 ZFP36 PAX2 PAX2 DAB2 DAB2 ZFP36L2 ZFP36L2 MARS1 MARS1 ENSNLEP00000024736 ENSNLEP00000024736 SOX9 SOX9 ENSNLEP00000027584 ENSNLEP00000027584 AKT1 AKT1 ENSNLEP00000028086 ENSNLEP00000028086 BAIAP2 BAIAP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC100605369Uncharacterized protein. (571 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
PPP1R9BProtein phosphatase 1 regulatory subunit 9B. (813 aa)
GAREM1GRB2 associated regulator of MAPK1 subtype 1. (888 aa)
ENSNLEP00000038711CFC domain-containing protein. (158 aa)
LOC100593010Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (459 aa)
PTPN12Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. (755 aa)
EEF1A1Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (462 aa)
ENSNLEP00000043688Uncharacterized protein. (273 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
ZPR1ZPR1 zinc finger. (459 aa)
VIL1Villin 1. (827 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (462 aa)
COL1A1Collagen type I alpha 1 chain. (1386 aa)
LOC100592336PH_3 domain-containing protein. (247 aa)
SYAP1Synapse associated protein 1. (293 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (155 aa)
PDE8APhosphodiesterase. (829 aa)
STAT5BSignal transducer and activator of transcription. (650 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1657 aa)
BAG4BCL2 associated athanogene 4. (456 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
DAB2IPDAB2 interacting protein. (1159 aa)
KNSTRNUncharacterized protein. (238 aa)
DUSP22Dual specificity phosphatase 22; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (205 aa)
ERBB2Receptor protein-tyrosine kinase. (1247 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
GAREM2GRB2 associated regulator of MAPK1 subtype 2. (837 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (188 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1182 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (372 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1558 aa)
NCLUncharacterized protein. (632 aa)
ZFP36ZFP36 ring finger protein. (322 aa)
PAX2Paired domain-containing protein. (385 aa)
DAB2DAB adaptor protein 2. (749 aa)
ZFP36L2ZFP36 ring finger protein like 2. (495 aa)
MARS1Methionyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (900 aa)
ENSNLEP00000024736Uncharacterized protein. (489 aa)
SOX9SRY-box transcription factor 9. (510 aa)
ENSNLEP00000027584SH2 domain-containing protein. (188 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
ENSNLEP00000028086Fork-head domain-containing protein. (459 aa)
BAIAP2BAI1 associated protein 2. (561 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.