STRINGSTRING
PCSK9 PCSK9 GOT1 GOT1 DDR2 DDR2 UMODL1 UMODL1 ENPP1 ENPP1 MAX MAX ARG1 ARG1 PLCB1 PLCB1 SLC30A10 SLC30A10 PARP1 PARP1 TGFB1 TGFB1 NFKB1 NFKB1 PRKDC PRKDC INSRR INSRR CRHBP CRHBP ASS1 ASS1 PHIP PHIP LEP LEP TYK2 TYK2 APC APC STAT3 STAT3 CAV2 CAV2 STAT5B STAT5B SRD5A1 SRD5A1 GLP1R GLP1R ZDHHC7 ZDHHC7 FER FER GPT GPT CEACAM1 CEACAM1 INSIG1 INSIG1 GSK3A GSK3A GCGR GCGR SPINK1 SPINK1 SYAP1 SYAP1 TRIB3 TRIB3 WDTC1 WDTC1 SLC9A1 SLC9A1 LOC100592336 LOC100592336 CCNA2 CCNA2 RPE65 RPE65 GNRHR GNRHR NKX6-1 NKX6-1 JAK2 JAK2 PDK2 PDK2 ERRFI1 ERRFI1 LHCGR LHCGR POR POR SH2B2 SH2B2 SLC2A4 SLC2A4 STXBP4 STXBP4 PTPRA PTPRA APPL1 APPL1 FN1 FN1 PRKCD PRKCD PCK1 PCK1 RAB12 RAB12 LPIN2 LPIN2 ADIPOQ ADIPOQ SLC26A6 SLC26A6 SMARCC1 SMARCC1 SOGA1 SOGA1 SLC29A2 SLC29A2 PIK3R2 PIK3R2 JAK3 JAK3 PIK3CA PIK3CA SOCS2 SOCS2 EDNRA EDNRA POU4F2 POU4F2 GHSR GHSR GAB1 GAB1 MEN1 MEN1 DNAI1 DNAI1 FGF21 FGF21 ZNF106 ZNF106 IGFBP1 IGFBP1 LOC100580921 LOC100580921 LOC100579700 LOC100579700 ACTN2 ACTN2 AHCYL1 AHCYL1 GCLC GCLC RB1 RB1 CA2 CA2 GRB14 GRB14 CDC6 CDC6 SRSF5 SRSF5 RAB10 RAB10 LOC100598080 LOC100598080 LYN LYN FOXO1 FOXO1 KL KL PPARG PPARG INPP5K INPP5K EDN1 EDN1 CRK CRK RPS6KB1 RPS6KB1 TRARG1 TRARG1 NR4A2 NR4A2 BRIP1 BRIP1 INSR INSR PRKCZ PRKCZ ZFP36L1 ZFP36L1 ENSNLEP00000037007 ENSNLEP00000037007 EEF2K EEF2K ENSNLEP00000037553 ENSNLEP00000037553 IL18 IL18 FOXO4 FOXO4 GRB10 GRB10 NCOA5 NCOA5 ADCY8 ADCY8 MAP1B MAP1B HSF1 HSF1 CAPN10 CAPN10 LOC100593010 LOC100593010 CYP11B2 CYP11B2 GRB2 GRB2 ENSNLEP00000041025 ENSNLEP00000041025 DENND4C DENND4C BCAR1 BCAR1 ENSNLEP00000041526 ENSNLEP00000041526 IDE IDE BCAR3 BCAR3 AKT2 AKT2 ENSNLEP00000042160 ENSNLEP00000042160 ENSNLEP00000042382 ENSNLEP00000042382 ENSNLEP00000042424 ENSNLEP00000042424 NFE2L2 NFE2L2 AGTR1 AGTR1 XBP1 XBP1 SELENOS SELENOS LOC100604571 LOC100604571 SLC25A33 SLC25A33 IGF1R IGF1R PTPN2 PTPN2 RAB8A RAB8A GPLD1 GPLD1 PIK3R3 PIK3R3 ENSNLEP00000045860 ENSNLEP00000045860 ENSNLEP00000045877 ENSNLEP00000045877 IRS2 IRS2 FBN1 FBN1 GHR GHR MYO5A MYO5A HMGCS2 HMGCS2 FOS FOS PXN PXN ENSNLEP00000048186 ENSNLEP00000048186 ANKRD26 ANKRD26 SRC SRC RAB15 RAB15 GLP2R GLP2R LOC100595279 LOC100595279 ENSNLEP00000049177 ENSNLEP00000049177 ENSNLEP00000036739 ENSNLEP00000036739 CPEB1 CPEB1 RELA RELA MGARP MGARP AP3S1 AP3S1 SLC39A14 SLC39A14 AGTR2 AGTR2 ENSNLEP00000035372 ENSNLEP00000035372 IRS1 IRS1 ENSNLEP00000035134 ENSNLEP00000035134 RAP1GDS1 RAP1GDS1 LOC100582356 LOC100582356 SORBS1 SORBS1 PTK2 PTK2 STAT1 STAT1 ENSNLEP00000034094 ENSNLEP00000034094 BAIAP2 BAIAP2 ENSNLEP00000032399 ENSNLEP00000032399 ITGB3 ITGB3 CAV1 CAV1 ENSNLEP00000032181 ENSNLEP00000032181 ENSNLEP00000032035 ENSNLEP00000032035 PIK3R1 PIK3R1 SREBF1 SREBF1 ENSNLEP00000030727 ENSNLEP00000030727 ADCY6 ADCY6 IGF2 IGF2 CYFIP1 CYFIP1 LPIN1 LPIN1 SLC27A1 SLC27A1 CPEB2 CPEB2 RAB13 RAB13 RAB31 RAB31 ENSNLEP00000028114 ENSNLEP00000028114 AKT1 AKT1 CPS1 CPS1 SLC22A12 SLC22A12 GCK GCK EPRS1 EPRS1 ENSNLEP00000027205 ENSNLEP00000027205 C2CD5 C2CD5 GSK3B GSK3B ENSNLEP00000026090 ENSNLEP00000026090 ENSNLEP00000025620 ENSNLEP00000025620 KAT2B KAT2B ENSNLEP00000025390 ENSNLEP00000025390 LPIN3 LPIN3 LOC100585742 LOC100585742 RHOQ RHOQ GPER1 GPER1 M3ZBW0_NOMLE M3ZBW0_NOMLE M3Z9R7_NOMLE M3Z9R7_NOMLE PRKCI PRKCI USF1 USF1 IRS4 IRS4 GPR173 GPR173 WNT1 WNT1 CSRP3 CSRP3 NR4A1 NR4A1 PDE3B PDE3B SP1 SP1 SLC2A8 SLC2A8 STAT6 STAT6 CDK4 CDK4 NR4A3 NR4A3 TSHR TSHR FBP1 FBP1 HDAC9 HDAC9 CYP1B1 CYP1B1 OTOP1 OTOP1 TBC1D4 TBC1D4 EIF4EBP2 EIF4EBP2 PDK4 PDK4 PNPLA3 PNPLA3 PLA2G1B PLA2G1B APRT APRT RANGAP1 RANGAP1 LOC100580921-2 LOC100580921-2 GHRHR GHRHR PCK2 PCK2 CRHR2 CRHR2 JAK1 JAK1 CCDC144A CCDC144A CSK CSK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PCSK9Proprotein convertase subtilisin/kexin type 9. (693 aa)
GOT1Aspartate aminotransferase. (413 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
UMODL1Uromodulin like 1. (1446 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (827 aa)
MAXMYC associated factor X. (160 aa)
ARG1Arginase. (322 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
SLC30A10Solute carrier family 30 member 10. (485 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (948 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit. (3853 aa)
INSRRTyrosine-protein kinase receptor. (1287 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
ASS1Uncharacterized protein. (412 aa)
PHIPPleckstrin homology domain interacting protein. (1953 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
TYK2Tyrosine-protein kinase. (1181 aa)
APCAPC regulator of WNT signaling pathway. (2844 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (86 aa)
STAT5BSignal transducer and activator of transcription. (650 aa)
SRD5A13-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (259 aa)
GLP1RGlucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (462 aa)
ZDHHC7Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (345 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
GPTGlutamic--pyruvic transaminase. (509 aa)
CEACAM1Uncharacterized protein. (493 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (274 aa)
GSK3AGlycogen synthase kinase 3 alpha. (439 aa)
GCGRGlucagon receptor; Belongs to the G-protein coupled receptor 2 family. (477 aa)
SPINK1Serine peptidase inhibitor, Kazal type 1. (79 aa)
SYAP1Synapse associated protein 1. (293 aa)
TRIB3Tribbles pseudokinase 3. (385 aa)
WDTC1WD and tetratricopeptide repeats 1. (677 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (809 aa)
LOC100592336PH_3 domain-containing protein. (247 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (431 aa)
RPE65Retinoid isomerohydrolase RPE65. (533 aa)
GNRHRGonadotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (328 aa)
NKX6-1NK6 homeobox 1. (368 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
PDK2Protein-serine/threonine kinase. (415 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (462 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (701 aa)
PORNADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (680 aa)
SH2B2Uncharacterized protein. (579 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (481 aa)
STXBP4Syntaxin binding protein 4. (539 aa)
PTPRAReceptor-type tyrosine-protein phosphatase alpha. (802 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (674 aa)
FN1Fibronectin 1. (2477 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (608 aa)
RAB12RAB12, member RAS oncogene family. (244 aa)
LPIN2Lipin 2. (896 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
SLC26A6Solute carrier family 26 member 6. (759 aa)
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1. (1009 aa)
SOGA1Suppressor of glucose, autophagy associated 1. (1643 aa)
SLC29A2Solute carrier family 29 member 2. (371 aa)
PIK3R2Uncharacterized protein. (727 aa)
JAK3Tyrosine-protein kinase. (1025 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
SOCS2Suppressor of cytokine signaling 2. (176 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
POU4F2POU domain protein. (408 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
MEN1Menin 1. (614 aa)
DNAI1Dynein axonemal intermediate chain 1. (700 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
ZNF106Zinc finger protein 106. (1863 aa)
IGFBP1Insulin like growth factor binding protein 1. (281 aa)
LOC100580921Uncharacterized protein. (216 aa)
LOC100579700Uncharacterized protein. (219 aa)
ACTN2Actinin alpha 2. (854 aa)
AHCYL1Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (529 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (637 aa)
RB1RB transcriptional corepressor 1. (919 aa)
CA2Carbonic anhydrase 2; Belongs to the alpha-carbonic anhydrase family. (260 aa)
GRB14Growth factor receptor bound protein 14. (540 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (560 aa)
SRSF5Serine and arginine rich splicing factor 5. (272 aa)
RAB10RAB10, member RAS oncogene family. (200 aa)
LOC100598080ANK_REP_REGION domain-containing protein. (513 aa)
LYNTyrosine-protein kinase. (512 aa)
FOXO1Forkhead box O1. (652 aa)
KLKlotho. (855 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (372 aa)
EDN1Endothelin 1. (211 aa)
CRKUncharacterized protein. (252 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (513 aa)
TRARG1Trafficking regulator of GLUT4 (SLC2A4) 1. (177 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1229 aa)
INSRInsulin receptor. (1232 aa)
PRKCZProtein kinase C zeta. (507 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
ENSNLEP00000037007Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (786 aa)
EEF2KEukaryotic elongation factor 2 kinase. (725 aa)
ENSNLEP00000037553Uncharacterized protein. (100 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
FOXO4Forkhead box O4. (505 aa)
GRB10Growth factor receptor bound protein 10. (612 aa)
NCOA5Nuclear receptor coactivator 5. (579 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1255 aa)
MAP1BMicrotubule associated protein 1B. (2370 aa)
HSF1HSF_DOMAIN domain-containing protein. (272 aa)
CAPN10Calpain 10; Belongs to the peptidase C2 family. (672 aa)
LOC100593010Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (459 aa)
CYP11B2Cytochrome P450 family 11 subfamily B member 2; Belongs to the cytochrome P450 family. (566 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
ENSNLEP00000041025Uncharacterized protein. (381 aa)
DENND4CDENN domain containing 4C. (1958 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (827 aa)
ENSNLEP00000041526G_PROTEIN_RECEP_F1_2 domain-containing protein. (332 aa)
IDEInsulin degrading enzyme. (976 aa)
BCAR3BCAR3 adaptor protein, NSP family member. (825 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (398 aa)
ENSNLEP00000042160Tyrosine-protein phosphatase non-receptor type. (386 aa)
ENSNLEP00000042382Uncharacterized protein. (425 aa)
ENSNLEP00000042424Tyrosine-protein phosphatase non-receptor type. (405 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (607 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
XBP1BZIP domain-containing protein. (376 aa)
SELENOSUncharacterized protein. (218 aa)
LOC100604571ANK_REP_REGION domain-containing protein. (213 aa)
SLC25A33Solute carrier family 25 member 33; Belongs to the mitochondrial carrier (TC 2.A.29) family. (324 aa)
IGF1RTyrosine-protein kinase receptor. (1199 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (415 aa)
RAB8ARAB8A, member RAS oncogene family. (197 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (840 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
ENSNLEP00000045860Uncharacterized protein. (64 aa)
ENSNLEP00000045877Uncharacterized protein. (116 aa)
IRS2Insulin receptor substrate 2. (1344 aa)
FBN1Fibrillin 1. (2873 aa)
GHRGrowth hormone receptor. (645 aa)
MYO5AMyosin VA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1867 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
PXNUncharacterized protein. (1078 aa)
ENSNLEP00000048186Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (466 aa)
ANKRD26Ankyrin repeat domain 26. (1708 aa)
SRCTyrosine-protein kinase. (537 aa)
RAB15Uncharacterized protein. (244 aa)
GLP2RGlucagon like peptide 2 receptor; Belongs to the G-protein coupled receptor 2 family. (553 aa)
LOC100595279Uncharacterized protein. (212 aa)
ENSNLEP00000049177Uncharacterized protein. (137 aa)
ENSNLEP00000036739Uncharacterized protein. (120 aa)
CPEB1Cytoplasmic polyadenylation element binding protein 1. (615 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
MGARPMitochondria localized glutamic acid rich protein. (238 aa)
AP3S1Adaptor related protein complex 3 subunit sigma 1. (193 aa)
SLC39A14Solute carrier family 39 member 14. (490 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
ENSNLEP00000035372TGF_BETA_2 domain-containing protein. (392 aa)
IRS1Insulin receptor substrate 1. (1242 aa)
ENSNLEP00000035134Uncharacterized protein. (101 aa)
RAP1GDS1Rap1 GTPase-GDP dissociation stimulator 1. (626 aa)
LOC100582356Uncharacterized protein. (217 aa)
SORBS1Uncharacterized protein. (1293 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1099 aa)
STAT1Signal transducer and activator of transcription. (780 aa)
ENSNLEP00000034094Uncharacterized protein. (313 aa)
BAIAP2BAI1 associated protein 2. (561 aa)
ENSNLEP00000032399Uncharacterized protein. (628 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (806 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
ENSNLEP00000032181Uncharacterized protein. (103 aa)
ENSNLEP00000032035Uncharacterized protein. (107 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1147 aa)
ENSNLEP00000030727Uncharacterized protein. (198 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1055 aa)
IGF2IlGF domain-containing protein. (180 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1228 aa)
LPIN1Lipin 1. (975 aa)
SLC27A1Solute carrier family 27 member 1. (571 aa)
CPEB2Uncharacterized protein. (500 aa)
RAB13Uncharacterized protein. (203 aa)
RAB31RAB31, member RAS oncogene family. (189 aa)
ENSNLEP00000028114Uncharacterized protein. (405 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
CPS1Carbamoyl-phosphate synthase 1. (1506 aa)
SLC22A12Solute carrier family 22 member 12. (553 aa)
GCKPhosphotransferase. (427 aa)
EPRS1Glutamyl-prolyl-tRNA synthetase. (1512 aa)
ENSNLEP00000027205Uncharacterized protein. (353 aa)
C2CD5C2 calcium dependent domain containing 5. (1042 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
ENSNLEP000000260903-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (258 aa)
ENSNLEP00000025620Uncharacterized protein. (154 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (799 aa)
ENSNLEP00000025390Tyrosine-protein phosphatase non-receptor type. (391 aa)
LPIN3Lipin 3. (859 aa)
LOC100585742Uncharacterized protein. (222 aa)
RHOQUncharacterized protein. (190 aa)
GPER1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (377 aa)
M3ZBW0_NOMLESH2 domain-containing protein. (230 aa)
M3Z9R7_NOMLECCDC144C domain-containing protein. (979 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
USF1Upstream transcription factor 1. (310 aa)
IRS4Insulin receptor substrate 4. (1257 aa)
GPR173G protein-coupled receptor 173. (373 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
CSRP3Cysteine and glycine rich protein 3. (194 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (589 aa)
PDE3BPhosphodiesterase. (791 aa)
SP1Sp1 transcription factor. (786 aa)
SLC2A8Solute carrier family 2 member 8; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (477 aa)
STAT6Signal transducer and activator of transcription. (842 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (636 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (764 aa)
FBP1Fructose-bisphosphatase 1. (281 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1066 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
OTOP1Otopetrin 1. (612 aa)
TBC1D4TBC1 domain family member 4. (1298 aa)
EIF4EBP2Uncharacterized protein. (120 aa)
PDK4Protein-serine/threonine kinase. (411 aa)
PNPLA3Patatin like phospholipase domain containing 3. (463 aa)
PLA2G1BPhospholipase A(2). (148 aa)
APRTAdenine phosphoribosyltransferase. (180 aa)
RANGAP1Ran GTPase activating protein 1. (526 aa)
LOC100580921-2Growth hormone B1. (217 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (424 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (575 aa)
CRHR2Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. (437 aa)
JAK1Tyrosine-protein kinase. (1149 aa)
CCDC144AUncharacterized protein. (1340 aa)
CSKTyrosine-protein kinase. (274 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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