STRINGSTRING
SOX10 SOX10 HIF1A HIF1A AXL AXL ENSNLEP00000047861 ENSNLEP00000047861 YTHDF2 YTHDF2 FZD5 FZD5 NTN4 NTN4 FBXO5 FBXO5 IGF1 IGF1 LHX6 LHX6 KDR KDR CATSPER2 CATSPER2 KCNIP2 KCNIP2 PABPC1L PABPC1L ENSNLEP00000043248 ENSNLEP00000043248 CX3CR1 CX3CR1 MAEA MAEA B4GALT5 B4GALT5 CCR6 CCR6 RFX3 RFX3 FGG FGG PHOSPHO1 PHOSPHO1 FOXA1 FOXA1 NF1 NF1 S1PR1 S1PR1 ENSNLEP00000038866 ENSNLEP00000038866 TDRD15 TDRD15 CABYR CABYR FEM1B FEM1B RYR1 RYR1 PPARG PPARG ENSNLEP00000036737 ENSNLEP00000036737 BCL2 BCL2 MECP2 MECP2 ENSNLEP00000035773 ENSNLEP00000035773 ENSNLEP00000035745 ENSNLEP00000035745 CDC25B CDC25B ENSNLEP00000035464 ENSNLEP00000035464 WDR77 WDR77 AGRN AGRN FARP2 FARP2 L3MBTL3 L3MBTL3 DEFB1 DEFB1 BAP1 BAP1 RND1 RND1 CATSPER4 CATSPER4 CNTN2 CNTN2 RHEX RHEX ANKRD17 ANKRD17 ENSNLEP00000032236 ENSNLEP00000032236 KDM1A KDM1A LOC100588616 LOC100588616 LOC100581267 LOC100581267 IFT80 IFT80 ENSNLEP00000029497 ENSNLEP00000029497 ENSNLEP00000029384 ENSNLEP00000029384 ENSNLEP00000029289 ENSNLEP00000029289 EPHA8 EPHA8 LOC100593129 LOC100593129 ASCL1 ASCL1 ENSNLEP00000027506 ENSNLEP00000027506 MTHFSD MTHFSD BRD1 BRD1 ERCC2 ERCC2 ENSNLEP00000026488 ENSNLEP00000026488 APP APP PTBP3 PTBP3 ENSNLEP00000025527 ENSNLEP00000025527 LOC100607679 LOC100607679 PRKACA PRKACA ENSNLEP00000025300 ENSNLEP00000025300 THBS3 THBS3 FGFR3 FGFR3 BHLHA15 BHLHA15 CDK5R2 CDK5R2 IQCF5 IQCF5 TUT4 TUT4 WNT1 WNT1 GDF11 GDF11 DCHS1 DCHS1 DDIT3 DDIT3 SLC24A4 SLC24A4 EPAS1 EPAS1 PTK2B PTK2B TDRD1 TDRD1 C3 C3 RET RET TDRD5 TDRD5 G1S044_NOMLE G1S044_NOMLE REC8 REC8 GHRHR GHRHR MYOC MYOC DMC1 DMC1 SNX10 SNX10 PAX2 PAX2 PMP22 PMP22 FLVCR1 FLVCR1 GATA2 GATA2 G6PD G6PD ADAMTS12 ADAMTS12 REN REN BMP2 BMP2 SPTBN4 SPTBN4 SCLT1 SCLT1 TGFB1 TGFB1 CATSPERD CATSPERD PLD6 PLD6 AKR1B1 AKR1B1 LYL1 LYL1 G1RPK2_NOMLE G1RPK2_NOMLE TMEM79 TMEM79 GATA3 GATA3 EPO EPO ACTL6B ACTL6B CFTR CFTR ROPN1L ROPN1L RPS6KA2 RPS6KA2 ABHD2 ABHD2 NSUN2 NSUN2 TDRD10 TDRD10 ALDH1A2 ALDH1A2 MTCH1 MTCH1 TRIP13 TRIP13 TDRKH TDRKH SOX18 SOX18 TRPC4AP TRPC4AP SPINK1 SPINK1 MBTPS2 MBTPS2 BFSP1 BFSP1 IL21 IL21 NKX6-1 NKX6-1 IHH IHH FEV FEV SLC26A8 SLC26A8 RERE RERE XYLT1 XYLT1 SLC26A3 SLC26A3 CCDC154 CCDC154 SOX8 SOX8 ANKS1A ANKS1A NRCAM NRCAM C1QA C1QA CATSPER3 CATSPER3 EREG EREG EBP EBP BTK BTK ZBTB16 ZBTB16 PGR PGR IQCF1 IQCF1 FAM210B FAM210B TUSC2 TUSC2 KCNB1 KCNB1 DAG1 DAG1 TYMS TYMS RHOA RHOA SLC26A6 SLC26A6 PLXNB1 PLXNB1 B4GALT6 B4GALT6 GLDN GLDN PTH1R PTH1R CTNNB1 CTNNB1 EDNRA EDNRA KLF2 KLF2 SLC22A14 SLC22A14 IL15 IL15 TUT7 TUT7 CATSPERZ CATSPERZ PHOSPHO2 PHOSPHO2 EPB42 EPB42 EXT1 EXT1 CCL21 CCL21 PDE3A PDE3A TDRD6 TDRD6 CBFB CBFB PLA2G3 PLA2G3 CATSPERE CATSPERE RECK RECK CDH5 CDH5 BFSP2 BFSP2 CNGB1 CNGB1 RB1 RB1 CX3CL1 CX3CL1 HOXB13 HOXB13 LOC100602359 LOC100602359 ATP6AP2 ATP6AP2 PLA2G10 PLA2G10 LOC100588056 LOC100588056 G1QKU7_NOMLE G1QKU7_NOMLE MMP2 MMP2 BRCA2 BRCA2 ADAMTS7 ADAMTS7 ROPN1B ROPN1B SCARF1 SCARF1 EDN1 EDN1 NR4A2 NR4A2 ADGRB3 ADGRB3 ROPN1 ROPN1 SEMA4D SEMA4D EFCAB9 EFCAB9 NOM1 NOM1 SRRM4 SRRM4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOX10HMG box domain-containing protein. (236 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
AXLReceptor protein-tyrosine kinase. (860 aa)
ENSNLEP00000047861annotation not available (282 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (595 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
NTN4Netrin 4. (623 aa)
FBXO5F-box protein 5. (428 aa)
IGF1IlGF domain-containing protein. (196 aa)
LHX6LIM homeobox 6. (352 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1367 aa)
CATSPER2Cation channel sperm associated 2. (488 aa)
KCNIP2Uncharacterized protein. (286 aa)
PABPC1LPABC domain-containing protein. (171 aa)
ENSNLEP00000043248Uncharacterized protein. (285 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (386 aa)
MAEAMacrophage erythroblast attacher. (383 aa)
B4GALT5Beta-1,4-galactosyltransferase 5. (388 aa)
CCR6C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (377 aa)
RFX3Regulatory factor X3. (760 aa)
FGGFibrinogen gamma chain. (463 aa)
PHOSPHO1Phosphoethanolamine/phosphocholine phosphatase. (292 aa)
FOXA1Uncharacterized protein. (346 aa)
NF1Neurofibromin 1. (2839 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
ENSNLEP00000038866DUF1279 domain-containing protein. (188 aa)
TDRD15Uncharacterized protein. (1608 aa)
CABYRRIIa domain-containing protein. (487 aa)
FEM1BFem-1 homolog B. (627 aa)
RYR1Ryanodine receptor 1. (4415 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
ENSNLEP00000036737Uncharacterized protein. (160 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
MECP2MBD domain-containing protein. (156 aa)
ENSNLEP00000035773Aldo_ket_red domain-containing protein. (273 aa)
ENSNLEP00000035745Uncharacterized protein. (229 aa)
CDC25BRhodanese domain-containing protein. (485 aa)
ENSNLEP00000035464Uncharacterized protein. (276 aa)
WDR77WD repeat domain 77. (347 aa)
AGRNAgrin. (1945 aa)
FARP2FERM, ARH/RhoGEF and pleckstrin domain protein 2. (1029 aa)
L3MBTL3L3MBTL histone methyl-lysine binding protein 3. (766 aa)
DEFB1Defensin beta 1. (68 aa)
BAP1Ubiquitin carboxyl-terminal hydrolase. (695 aa)
RND1Rho family GTPase 1. (214 aa)
CATSPER4Cation channel sperm associated 4. (483 aa)
CNTN2Contactin 2. (1049 aa)
RHEXRegulator of hemoglobinization and erythroid cell expansion. (172 aa)
ANKRD17Ankyrin repeat domain 17. (2603 aa)
ENSNLEP00000032236Uncharacterized protein. (109 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (759 aa)
LOC100588616Runt domain-containing protein. (504 aa)
LOC100581267Uncharacterized protein. (121 aa)
IFT80Intraflagellar transport 80. (777 aa)
ENSNLEP00000029497PLD phosphodiesterase domain-containing protein. (233 aa)
ENSNLEP00000029384Uncharacterized protein. (128 aa)
ENSNLEP00000029289Uncharacterized protein. (456 aa)
EPHA8EPH receptor A8. (987 aa)
LOC100593129Rhodanese domain-containing protein. (501 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (235 aa)
ENSNLEP00000027506Uncharacterized protein. (265 aa)
MTHFSDMethenyltetrahydrofolate synthetase domain containing. (383 aa)
BRD1Bromodomain containing 1. (1059 aa)
ERCC2Helicase ATP-binding domain-containing protein. (625 aa)
ENSNLEP00000026488Aldo_ket_red domain-containing protein. (282 aa)
APPAmyloid beta precursor protein. (757 aa)
PTBP3Polypyrimidine tract binding protein 3. (554 aa)
ENSNLEP00000025527Uncharacterized protein. (317 aa)
LOC100607679SCY domain-containing protein. (98 aa)
PRKACAProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (294 aa)
ENSNLEP00000025300Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (346 aa)
THBS3Thrombospondin 3. (938 aa)
FGFR3Receptor protein-tyrosine kinase. (583 aa)
BHLHA15Basic helix-loop-helix family member a15. (189 aa)
CDK5R2Cyclin-dependent kinase 5 activator. (367 aa)
IQCF5IQ motif containing F5. (148 aa)
TUT4Terminal uridylyl transferase 4. (1628 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
GDF11TGF_BETA_2 domain-containing protein. (377 aa)
DCHS1Dachsous cadherin-related 1. (3297 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa)
SLC24A4Solute carrier family 24 member 4; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (622 aa)
EPAS1Endothelial PAS domain protein 1. (869 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (871 aa)
TDRD1Tudor domain containing 1. (1153 aa)
C3Complement C3. (1424 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1114 aa)
TDRD5Tudor domain containing 5. (1035 aa)
G1S044_NOMLEUncharacterized protein. (236 aa)
REC8REC8 meiotic recombination protein. (541 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (424 aa)
MYOCMyocilin. (526 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (340 aa)
SNX10Sorting nexin 10. (201 aa)
PAX2Paired domain-containing protein. (385 aa)
PMP22Peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system; Belongs to the PMP-22/EMP/MP20 family. (160 aa)
FLVCR1Feline leukemia virus subgroup C cellular receptor 1. (555 aa)
GATA2GATA binding protein 2. (480 aa)
G6PDUncharacterized protein. (452 aa)
ADAMTS12ADAM metallopeptidase with thrombospondin type 1 motif 12. (1601 aa)
RENRenin; Belongs to the peptidase A1 family. (388 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
SPTBN4Spectrin beta chain; Belongs to the spectrin family. (2474 aa)
SCLT1Sodium channel and clathrin linker 1. (688 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CATSPERDCation channel sperm associated auxiliary subunit delta. (727 aa)
PLD6PLD phosphodiesterase domain-containing protein. (252 aa)
AKR1B1Aldo-keto reductase family 1 member B. (316 aa)
LYL1LYL1 basic helix-loop-helix family member. (280 aa)
G1RPK2_NOMLEUncharacterized protein. (153 aa)
TMEM79Transmembrane protein 79. (394 aa)
GATA3GATA binding protein 3. (444 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
ACTL6BActin like 6B; Belongs to the actin family. (426 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1480 aa)
ROPN1LRhophilin associated tail protein 1 like. (230 aa)
RPS6KA2Non-specific serine/threonine protein kinase. (692 aa)
ABHD2Abhydrolase domain containing 2. (437 aa)
NSUN2NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (767 aa)
TDRD10Tudor domain containing 10. (322 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
MTCH1Mitochondrial carrier 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (389 aa)
TRIP13Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (432 aa)
TDRKHTudor and KH domain containing. (596 aa)
SOX18SRY-box transcription factor 18. (362 aa)
TRPC4APTransient receptor potential cation channel subfamily C member 4 associated protein. (781 aa)
SPINK1Serine peptidase inhibitor, Kazal type 1. (79 aa)
MBTPS2Membrane bound transcription factor peptidase, site 2. (502 aa)
BFSP1Beaded filament structural protein 1; Belongs to the intermediate filament family. (653 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
NKX6-1NK6 homeobox 1. (368 aa)
IHHIndian hedgehog signaling molecule. (389 aa)
FEVFEV transcription factor, ETS family member. (228 aa)
SLC26A8Testis anion transporter 1. (968 aa)
REREArginine-glutamic acid dipeptide repeats. (1566 aa)
XYLT1Xylosyltransferase 1. (925 aa)
SLC26A3Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (759 aa)
CCDC154Coiled-coil domain containing 154. (632 aa)
SOX8SRY-box transcription factor 8. (446 aa)
ANKS1AAnkyrin repeat and sterile alpha motif domain containing 1A. (1110 aa)
NRCAMNeuronal cell adhesion molecule. (1304 aa)
C1QAComplement C1q A chain. (245 aa)
CATSPER3Cation channel sperm associated 3. (397 aa)
EREGEpiregulin. (169 aa)
EBPEXPERA domain-containing protein. (230 aa)
BTKTyrosine-protein kinase. (659 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
PGRUncharacterized protein. (339 aa)
IQCF1IQ motif containing F1. (177 aa)
FAM210BDUF1279 domain-containing protein. (192 aa)
TUSC2Tumor suppressor 2, mitochondrial calcium regulator. (110 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
DAG1Dystroglycan 1. (895 aa)
TYMSThymidylat_synt domain-containing protein. (173 aa)
RHOARas homolog family member A. (193 aa)
SLC26A6Solute carrier family 26 member 6. (759 aa)
PLXNB1Plexin B1. (2079 aa)
B4GALT6Beta-1,4-galactosyltransferase 6. (382 aa)
GLDNGliomedin. (569 aa)
PTH1RParathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (574 aa)
CTNNB1Catenin beta 1. (781 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
KLF2Kruppel like factor 2. (355 aa)
SLC22A14Uncharacterized protein. (555 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
TUT7Terminal uridylyl transferase 7. (1493 aa)
CATSPERZCatsper channel auxiliary subunit zeta. (182 aa)
PHOSPHO2Phosphatase, orphan 2. (241 aa)
EPB42Erythrocyte membrane protein band 4.2. (691 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (745 aa)
CCL21C-C motif chemokine ligand 21. (134 aa)
PDE3APhosphodiesterase. (1141 aa)
TDRD6Tudor domain containing 6. (2094 aa)
CBFBCore-binding factor subunit beta. (182 aa)
PLA2G3Phospholipase A2 group III. (509 aa)
CATSPERECatsper channel auxiliary subunit epsilon. (932 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (971 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (687 aa)
BFSP2Beaded filament structural protein 2; Belongs to the intermediate filament family. (415 aa)
CNGB1Cyclic nucleotide gated channel subunit beta 1. (1212 aa)
RB1RB transcriptional corepressor 1. (919 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (397 aa)
HOXB13Homeobox B13. (284 aa)
LOC100602359Uncharacterized protein. (479 aa)
ATP6AP2ATPase H+ transporting accessory protein 2. (350 aa)
PLA2G10Phospholipase A(2). (129 aa)
LOC100588056Fibronectin type-II domain-containing protein. (75 aa)
G1QKU7_NOMLEUncharacterized protein. (118 aa)
MMP2Matrix metallopeptidase 2. (647 aa)
BRCA2BRCA2 DNA repair associated. (3419 aa)
ADAMTS7PLAC domain-containing protein. (1200 aa)
ROPN1BUncharacterized protein. (120 aa)
SCARF1Scavenger receptor class F member 1. (795 aa)
EDN1Endothelin 1. (211 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
ADGRB3Adhesion G protein-coupled receptor B3; Belongs to the G-protein coupled receptor 2 family. (1522 aa)
ROPN1Rhophilin associated tail protein 1. (212 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (862 aa)
EFCAB9EF-hand calcium binding domain 9. (197 aa)
NOM1Nucleolar protein with MIF4G domain 1. (858 aa)
SRRM4Serine/arginine repetitive matrix 4. (615 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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