STRINGSTRING
PLXNB2 PLXNB2 SETD2 SETD2 HIF1A HIF1A COBL COBL CLUAP1 CLUAP1 RARG RARG SUFU SUFU MTHFR MTHFR PFN1-2 PFN1-2 KDM2B KDM2B ENSNLEP00000045640 ENSNLEP00000045640 LRRC1 LRRC1 ENSNLEP00000045603 ENSNLEP00000045603 ENSNLEP00000044942 ENSNLEP00000044942 MTHFD1 MTHFD1 FZD2 FZD2 MED12 MED12 DVL2 DVL2 IFT122 IFT122 NOG NOG DVL1 DVL1 ENSNLEP00000041504 ENSNLEP00000041504 BCL10 BCL10 ENSNLEP00000039759 ENSNLEP00000039759 MKS1 MKS1 TSC2 TSC2 TCAP TCAP LOC100601167 LOC100601167 LOC100593615 LOC100593615 DLC1 DLC1 SEMA4C SEMA4C RPS7 RPS7 ENSNLEP00000033749 ENSNLEP00000033749 GRHL3 GRHL3 ENSNLEP00000032709 ENSNLEP00000032709 IRX3 IRX3 FOLR1 FOLR1 LIAS LIAS LUZP1 LUZP1 SPINT1 SPINT1 FGF10 FGF10 PRKACB PRKACB PHACTR4 PHACTR4 GDNF GDNF STK4 STK4 LHX2 LHX2 ENSNLEP00000027432 ENSNLEP00000027432 IFT57 IFT57 SOX9 SOX9 STK3 STK3 BRD2 BRD2 PRKACA PRKACA KDM6A KDM6A DVL3 DVL3 LMO4 LMO4 TRAF6 TRAF6 PRICKLE1 PRICKLE1 ADM ADM FGFR2 FGFR2 PTCH1 PTCH1 FZD3 FZD3 SEC24B SEC24B HAND1 HAND1 STIL STIL CC2D2A CC2D2A NODAL NODAL HECTD1 HECTD1 RET RET CELSR1 CELSR1 MTHFD1L MTHFD1L CITED2 CITED2 FGF8 FGF8 PAX2 PAX2 PROX1 PROX1 TGFB2 TGFB2 BBS4 BBS4 SIX1 SIX1 TGFB1 TGFB1 VANGL2 VANGL2 TSC1 TSC1 PODXL PODXL BMP4 BMP4 SFRP1 SFRP1 ABL1 ABL1 KIF20B KIF20B GATA3 GATA3 TBXT TBXT KAT2A KAT2A IRX2 IRX2 CASP3 CASP3 GREM1 GREM1 GLMN GLMN HS2ST1 HS2ST1 WNT6 WNT6 DEAF1 DEAF1 SOX8 SOX8 SHROOM3 SHROOM3 CECR2 CECR2 ST14 ST14 HESX1 HESX1 WNT5A WNT5A BMP7 BMP7 SALL4 SALL4 OPA1 OPA1 MIB1 MIB1 SDC4 SDC4 IFT52 IFT52 APAF1 APAF1 SFRP2 SFRP2 CTNNB1 CTNNB1 CEP290 CEP290 FUZ FUZ WNT9B WNT9B LRP2 LRP2 TRIM71 TRIM71 PTK7 PTK7 IFT172 IFT172 CTHRC1 CTHRC1 FZD6 FZD6 GRHL2 GRHL2 BMP5 BMP5 TCTN1 TCTN1 RALA RALA ARHGAP35 ARHGAP35 TULP3 TULP3 GDF7 GDF7 VASP VASP SCRIB SCRIB OSR1 OSR1 RARA RARA SOX4 SOX4 TMED2 TMED2 SHANK3 SHANK3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLXNB2Plexin B2. (1647 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2498 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
COBLCordon-bleu WH2 repeat protein. (1347 aa)
CLUAP1Clusterin associated protein 1. (431 aa)
RARGRetinoic acid receptor gamma. (441 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (526 aa)
MTHFRMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (654 aa)
PFN1-2Profilin; Belongs to the profilin family. (128 aa)
KDM2BLysine demethylase 2B. (1290 aa)
ENSNLEP0000004564040S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (167 aa)
LRRC1Leucine rich repeat containing 1. (503 aa)
ENSNLEP00000045603Uncharacterized protein. (252 aa)
ENSNLEP00000044942THF_DHG_CYH domain-containing protein. (111 aa)
MTHFD1Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (990 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (543 aa)
MED12Mediator complex subunit 12. (2109 aa)
DVL2Dishevelled segment polarity protein 2. (713 aa)
IFT122Intraflagellar transport 122. (1266 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
DVL1Dishevelled segment polarity protein 1. (667 aa)
ENSNLEP0000004150440S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (179 aa)
BCL10CARD domain-containing protein. (319 aa)
ENSNLEP00000039759GOLD domain-containing protein. (183 aa)
MKS1MKS transition zone complex subunit 1. (546 aa)
TSC2TSC complex subunit 2. (1777 aa)
TCAPTitin-cap. (167 aa)
LOC10060116740S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (180 aa)
LOC100593615TPR_REGION domain-containing protein. (160 aa)
DLC1DLC1 Rho GTPase activating protein. (1528 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (833 aa)
RPS740S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (194 aa)
ENSNLEP0000003374940S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (194 aa)
GRHL3Grainyhead like transcription factor 3. (597 aa)
ENSNLEP00000032709Profilin; Belongs to the profilin family. (120 aa)
IRX3Iroquois homeobox 3. (476 aa)
FOLR1Folate receptor alpha. (228 aa)
LIASLipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (372 aa)
LUZP1Leucine zipper protein 1. (1076 aa)
SPINT1Serine peptidase inhibitor, Kunitz type 1. (530 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
PHACTR4Phosphatase and actin regulator. (512 aa)
GDNFTGF_BETA_2 domain-containing protein. (169 aa)
STK4Serine/threonine kinase 4. (490 aa)
LHX2LIM homeobox 2. (406 aa)
ENSNLEP00000027432TNF receptor-associated factor. (488 aa)
IFT57Intraflagellar transport 57. (429 aa)
SOX9SRY-box transcription factor 9. (510 aa)
STK3Serine/threonine kinase 3. (519 aa)
BRD2Bromodomain containing 2. (827 aa)
PRKACAProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (294 aa)
KDM6ALysine demethylase 6A. (1450 aa)
DVL3Dishevelled segment polarity protein 3. (673 aa)
LMO4LIM domain only 4. (165 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
PRICKLE1Prickle planar cell polarity protein 1. (831 aa)
ADMAdrenomedullin. (184 aa)
FGFR2Fibroblast growth factor receptor. (820 aa)
PTCH1Patched 1. (1446 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1236 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
STILSTIL centriolar assembly protein. (1279 aa)
CC2D2ACoiled-coil and C2 domain containing 2A. (1620 aa)
NODALNodal growth differentiation factor. (347 aa)
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2610 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1114 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (2918 aa)
MTHFD1LMethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (950 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
PAX2Paired domain-containing protein. (385 aa)
PROX1Prospero homeobox 1. (737 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
BBS4Bardet-Biedl syndrome 4. (518 aa)
SIX1SIX homeobox 1. (284 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
VANGL2Uncharacterized protein. (435 aa)
TSC1TSC complex subunit 1. (1164 aa)
PODXLUncharacterized protein. (644 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
ABL1Tyrosine-protein kinase. (1006 aa)
KIF20BKinesin family member 20B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1822 aa)
GATA3GATA binding protein 3. (444 aa)
TBXTT-box transcription factor T. (435 aa)
KAT2AUncharacterized protein. (476 aa)
IRX2Iroquois homeobox 2. (471 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
GREM1CTCK domain-containing protein. (143 aa)
GLMNGlomulin, FKBP associated protein. (550 aa)
HS2ST1Heparan sulfate 2-O-sulfotransferase 1. (309 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
DEAF1DEAF1 transcription factor. (555 aa)
SOX8SRY-box transcription factor 8. (446 aa)
SHROOM3Shroom family member 3. (1996 aa)
CECR2CECR2 histone acetyl-lysine reader. (1441 aa)
ST14Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family. (855 aa)
HESX1HESX homeobox 1. (185 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
BMP7Bone morphogenetic protein 7. (430 aa)
SALL4Spalt like transcription factor 4. (1053 aa)
OPA1OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (957 aa)
MIB1Mindbomb E3 ubiquitin protein ligase 1. (985 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (198 aa)
IFT52Intraflagellar transport 52. (396 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
SFRP2Secreted frizzled related protein 2. (280 aa)
CTNNB1Catenin beta 1. (781 aa)
CEP290Centrosomal protein 290. (2446 aa)
FUZFuzzy planar cell polarity protein. (398 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
LRP2LDL receptor related protein 2. (4624 aa)
TRIM71Tripartite motif containing 71. (868 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1078 aa)
IFT172Intraflagellar transport 172. (1703 aa)
CTHRC1Collagen triple helix repeat containing 1. (242 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
GRHL2Grainyhead like transcription factor 2. (625 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
TCTN1Tectonic family member 1. (598 aa)
RALARAS like proto-oncogene A. (206 aa)
ARHGAP35Rho GTPase activating protein 35. (1499 aa)
TULP3TUB like protein 3; Belongs to the TUB family. (463 aa)
GDF7Growth differentiation factor 7. (450 aa)
VASPVasodilator stimulated phosphoprotein. (341 aa)
SCRIBScribble planar cell polarity protein. (1449 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
RARARetinoic acid receptor alpha. (458 aa)
SOX4Transcription factor SOX. (459 aa)
TMED2Transmembrane p24 trafficking protein 2. (199 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1521 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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