STRINGSTRING
TNKS TNKS GSKIP GSKIP G1QIV4_NOMLE G1QIV4_NOMLE LRRK1 LRRK1 JRK JRK ATP6AP2 ATP6AP2 SOX4 SOX4 GPC3 GPC3 NLE1 NLE1 PPM1N PPM1N DAPK3 DAPK3 TTC21B TTC21B UBR5 UBR5 PPP2R3A PPP2R3A RECK RECK PTK7 PTK7 VCP VCP CDH3 CDH3 TBL1XR1 TBL1XR1 SFRP2 SFRP2 USP8 USP8 KANK1 KANK1 LYPD6 LYPD6 COL1A1 COL1A1 WLS WLS TMEM198 TMEM198 GID8 GID8 JUP JUP SEMA5A SEMA5A RSPO1 RSPO1 PIN1 PIN1 ADGRA2 ADGRA2 SFRP1 SFRP1 HHEX HHEX CSNK1G2 CSNK1G2 FGF9 FGF9 DACT1 DACT1 NFKB1 NFKB1 PPM1A PPM1A TGFB1 TGFB1 RNF220 RNF220 RSPO3 RSPO3 RNF146 RNF146 RUVBL1 RUVBL1 PRDM15 PRDM15 RPS12 RPS12 SMURF2 SMURF2 XIAP XIAP LOC100607246 LOC100607246 VPS35 VPS35 CCAR2 CCAR2 DLX5 DLX5 SCEL SCEL GPC5 GPC5 EGF EGF PPM1B PPM1B FGFR2 FGFR2 BAMBI BAMBI ARNTL ARNTL LGR4 LGR4 LRRK2 LRRK2 ASPM ASPM TMEM9 TMEM9 LGR6 LGR6 FZD9 FZD9 TNKS2 TNKS2 USP47 USP47 WNT3A WNT3A ENSNLEP00000026979 ENSNLEP00000026979 ENSNLEP00000027025 ENSNLEP00000027025 DAAM2 DAAM2 AMER1 AMER1 ENSNLEP00000027887 ENSNLEP00000027887 DDX3X DDX3X FGF10 FGF10 PLEKHA4 PLEKHA4 CAPRIN2 CAPRIN2 ENSNLEP00000031324 ENSNLEP00000031324 YAP1 YAP1 CAV1 CAV1 ENSNLEP00000032476 ENSNLEP00000032476 ENSNLEP00000032543 ENSNLEP00000032543 FAM53B FAM53B ENSNLEP00000033625 ENSNLEP00000033625 ENSNLEP00000034412 ENSNLEP00000034412 ENSNLEP00000035464 ENSNLEP00000035464 ZEB2 ZEB2 EGFR EGFR TRPM4 TRPM4 EDA EDA CSNK1G1 CSNK1G1 ENSNLEP00000039612 ENSNLEP00000039612 DKK2 DKK2 SMAD3 SMAD3 NRARP NRARP CTDNEP1 CTDNEP1 USP34 USP34 GPRC5B GPRC5B WNK1 WNK1 LGR5 LGR5 WNT10B WNT10B ENSNLEP00000046839 ENSNLEP00000046839 BIRC8 BIRC8 WNK2 WNK2 SFRP4 SFRP4 ENSNLEP00000048301 ENSNLEP00000048301 SRC SRC RSPO2 RSPO2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TNKSPoly [ADP-ribose] polymerase. (1312 aa)
GSKIPGSK3B interacting protein. (144 aa)
G1QIV4_NOMLETNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (253 aa)
LRRK1Leucine rich repeat kinase 1. (1816 aa)
JRKJrk helix-turn-helix protein. (556 aa)
ATP6AP2ATPase H+ transporting accessory protein 2. (350 aa)
SOX4Transcription factor SOX. (459 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
NLE1Notchless homolog 1. (485 aa)
PPM1NProtein phosphatase, Mg2+/Mn2+ dependent 1N (putative). (430 aa)
DAPK3Death associated protein kinase 3. (407 aa)
TTC21BTetratricopeptide repeat domain 21B. (1283 aa)
UBR5Ubiquitin protein ligase E3 component n-recognin 5. (2778 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1150 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (971 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1078 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (808 aa)
CDH3Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (829 aa)
TBL1XR1Transducin beta like 1 X-linked receptor 1. (514 aa)
SFRP2Secreted frizzled related protein 2. (280 aa)
USP8Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1117 aa)
KANK1KN motif and ankyrin repeat domains 1. (1352 aa)
LYPD6LY6/PLAUR domain containing 6. (171 aa)
COL1A1Collagen type I alpha 1 chain. (1386 aa)
WLSWnt ligand secretion mediator. (542 aa)
TMEM198Transmembrane protein 198. (360 aa)
GID8GID complex subunit 8 homolog. (228 aa)
JUPJunction plakoglobin. (730 aa)
SEMA5ASemaphorin 5A. (1074 aa)
RSPO1R-spondin 1. (237 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1128 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
HHEXHomeobox domain-containing protein. (231 aa)
CSNK1G2Protein kinase domain-containing protein. (379 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (837 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
RNF220Ring finger protein 220. (566 aa)
RSPO3R-spondin 3. (292 aa)
RNF146Ring finger protein 146. (359 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
PRDM15Uncharacterized protein. (1252 aa)
RPS1240S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family. (132 aa)
SMURF2E3 ubiquitin-protein ligase. (745 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
LOC100607246Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
VPS35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (790 aa)
CCAR2Cell cycle and apoptosis regulator 2. (923 aa)
DLX5Homeobox domain-containing protein. (191 aa)
SCELSciellin. (688 aa)
GPC5Glypican 5; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (572 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
PPM1BPPM-type phosphatase domain-containing protein. (387 aa)
FGFR2Fibroblast growth factor receptor. (820 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (247 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (620 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (929 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
ASPMAbnormal spindle microtubule assembly. (3388 aa)
TMEM9Transmembrane protein 9. (183 aa)
LGR6Leucine rich repeat containing G protein-coupled receptor 6. (896 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
TNKS2Poly [ADP-ribose] polymerase. (1166 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1375 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
ENSNLEP0000002697940S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family. (131 aa)
ENSNLEP00000027025PPM-type phosphatase domain-containing protein. (340 aa)
DAAM2Dishevelled associated activator of morphogenesis 2. (1012 aa)
AMER1Uncharacterized protein. (805 aa)
ENSNLEP00000027887DUF4203 domain-containing protein. (101 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (704 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PLEKHA4Pleckstrin homology domain containing A4. (720 aa)
CAPRIN2Caprin family member 2. (1119 aa)
ENSNLEP00000031324Uncharacterized protein. (255 aa)
YAP1Uncharacterized protein. (418 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
ENSNLEP00000032476FCP1 homology domain-containing protein. (231 aa)
ENSNLEP00000032543Uncharacterized protein. (168 aa)
FAM53BFamily with sequence similarity 53 member B. (425 aa)
ENSNLEP0000003362540S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family. (129 aa)
ENSNLEP0000003441240S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family. (141 aa)
ENSNLEP00000035464Uncharacterized protein. (276 aa)
ZEB2Zinc finger E-box binding homeobox 2. (1253 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
TRPM4Uncharacterized protein. (1010 aa)
EDAUncharacterized protein. (145 aa)
CSNK1G1Casein kinase 1 gamma 1; Belongs to the protein kinase superfamily. (475 aa)
ENSNLEP00000039612Uncharacterized protein. (517 aa)
DKK2Dickkopf WNT signaling pathway inhibitor 2. (259 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
CTDNEP1FCP1 homology domain-containing protein. (111 aa)
USP34Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family. (3536 aa)
GPRC5BG protein-coupled receptor class C group 5 member B. (344 aa)
WNK1WNK lysine deficient protein kinase 1. (2833 aa)
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (907 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (335 aa)
ENSNLEP00000046839DUF4203 domain-containing protein. (93 aa)
BIRC8Uncharacterized protein. (221 aa)
WNK2WNK lysine deficient protein kinase 2. (1977 aa)
SFRP4Secreted frizzled related protein 4. (369 aa)
ENSNLEP00000048301Peptidyl-prolyl cis-trans isomerase. (144 aa)
SRCTyrosine-protein kinase. (537 aa)
RSPO2R-spondin 2. (250 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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