STRINGSTRING
FLCN FLCN FFAR4 FFAR4 LEP LEP SIRT1 SIRT1 PIM1 PIM1 VSTM2A VSTM2A TFE3 TFE3 BMP7 BMP7 FNDC5 FNDC5 TRPV4 TRPV4 HNRNPU HNRNPU NAPEPLD NAPEPLD DUSP10 DUSP10 RREB1 RREB1 ENSNLEP00000030707 ENSNLEP00000030707 MAPK14 MAPK14 ZBTB7B ZBTB7B PTGS2 PTGS2 GATA2 GATA2 SOX13 SOX13 SIX1 SIX1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FLCNFolliculin. (542 aa)
FFAR4G_PROTEIN_RECEP_F1_2 domain-containing protein. (235 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
SIRT1Sirtuin 1. (734 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (402 aa)
VSTM2AIg-like domain-containing protein. (292 aa)
TFE3Transcription factor binding to IGHM enhancer 3. (575 aa)
BMP7Bone morphogenetic protein 7. (430 aa)
FNDC5Fibronectin type III domain containing 5. (212 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (846 aa)
HNRNPUB30.2/SPRY domain-containing protein. (725 aa)
NAPEPLDN-acyl phosphatidylethanolamine phospholipase D. (395 aa)
DUSP10Dual specificity phosphatase 10. (482 aa)
RREB1Ras responsive element binding protein 1. (1719 aa)
ENSNLEP00000030707Uncharacterized protein. (159 aa)
MAPK14Mitogen-activated protein kinase. (321 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (573 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
GATA2GATA binding protein 2. (480 aa)
SOX13SRY-box transcription factor 13. (622 aa)
SIX1SIX homeobox 1. (284 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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